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The usefulness of99mTc-hexamethylpropyleneamineoxime white blood cell scintigraphy in a patient with eosinophilic gastroenteritis

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Abstract

White blood cell (WBC)99mTc-hexamethylpropyleneamineoxime (HMPAO) scintigraphy was performed in a patient with eosinophilic gastroenteritis. WBC accumulation was detected in the terminal ileum to descending colon, and pathological studies demonstrated eosinophilic infiltration at the same region.99mTc-HMPAO-WBC scintigraphy was proved to be a useful tool for the detection of eosinophilic infiltration in eosinophilic gastroenteritis.

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References

  1. Kaijser R. Zur Kenntnis der allegischen Affektioner desima Verdauungskanal von Standpunkt desima Chirurgen aus.Arch Klin Chir 1937; 188: 36–64.

    Google Scholar 

  2. Keshavarzian A, Saverymuttu SH, Tai PC, et al. Activated eosinophils in familial eosinophilic gastroenteritis.Gastroenterology 1985; 88: 1041–1049.

    PubMed  CAS  Google Scholar 

  3. Cello JP. Eosinophilic gastroenteritis—a complex disease entity.Am J Med 1979; 67: 1097–1104.

    Article  PubMed  CAS  Google Scholar 

  4. Goldberg HI, O’Kieffe D, Jenis EH, Boyce HW. Diffuse eosinophilic gastroenteritis.Am J Roentgenol Radium ther Nuc Med 1973; 119: 342–351.

    CAS  Google Scholar 

  5. Haberkern CM, Christie DL, Haas JE. Eosinophilic gastroenteritis presenting as ileocolitis.Gastroenterology 1978; 74: 896–899.

    PubMed  CAS  Google Scholar 

  6. Klein NC, Hargrove RL, Sleisenger MH, Jeffries GH. Eosinophilic gastroenteritis.Medicine 1970; 49: 299–319.

    Article  PubMed  CAS  Google Scholar 

  7. Moots RJ, Prouse P, Gumpel JM. Near fatal eosinophilic gastroenteritis responding to oral sodium chromoglycate.Gut 1988; 29: 1282–1285.

    Article  PubMed  CAS  Google Scholar 

  8. Lee KJ, Hahm KB, Kim YS, Kim JH, Cho SW, Jie H, et al. The usefulness of99mTc-HMPAO labeled WBC SPECT in eosinophilic gastroenteritis.Clin Nucl Med 1997; 22: 536–541.

    Article  PubMed  CAS  Google Scholar 

  9. Puncher MRB, Blower PJ. Autoradiography and density gradient separation of technetium-99m-Exametazime (HMPAO) labeled leucocytes reveal selectivity for eosinophils.Eur J Nucl Med 1994; 21: 1175–1182.

    PubMed  CAS  Google Scholar 

  10. Colak T, Gungor F, Ozugur S, Bozan H, Yildiz A, Boz A, et al. The value of99mTc-HMPAO labelled white blood cell scintigraphy in acute appendicitis patients with an equivocal clinical presentation.Eur J Nucl Med 2001; 28: 575–580.

    Article  PubMed  CAS  Google Scholar 

  11. Bennink R, Peeters M, D’Haens G, Rutgeerts P, Mortelmans L.99mTc-HMPAO white blood cell scintigraphy in the assessment of the extent and severity of an acute exacerbation of ulcerative colitis.Clin Nucl Med 2001; 26: 99–104.

    Article  PubMed  CAS  Google Scholar 

  12. Malcolm PN, Bearcroft CP, Pratt PG, Rampton DS, Garvie NW. Technetium-99m hexamethylpropyleneamineoxime labeled leucocyte scanning in the diagnosis of Crohn’s disease.Br J Radiol 1994; 67: 964–968.

    Article  PubMed  CAS  Google Scholar 

  13. Japan Isotope Society. Standard nuclear medicine imaging protocol.Radioisotopes 1994; 43: 103–104. (in Japanese).

    Google Scholar 

  14. Ell PJ, Hocknell JMK, Jarritt PH. A99mTc labelled radio tracer for the investigation of cerebral vascular disease.Nucl Med Commun 1985; 6: 437–441.

    Article  PubMed  CAS  Google Scholar 

  15. Peters AM, Danpure HJ, Osman S, Hawker RJ, Henderson BL, Hodgson HJ, et al. Clinical experience with99mTc-hexamethylpropyleneamineoxime for labelling leucocytes and imaging inflammation.Lancet 1986; 25: 946–949.

    Article  Google Scholar 

  16. Roddie ME, Peters AM, Danpure HJ, et al. Inflammation: imaging with Tc-99m HMPAO-labeled leukocytes.Radiology 1988; 166: 767–772.

    PubMed  CAS  Google Scholar 

  17. Saitoh Y, Aburano T, Takashio T, Shuke N, Ayabe T, Nomura M, et al. Clinical Evaluation of99mTc-HMPAO Labeled leukocyte Imaging in Ulcerative Colitis.KAKU IGAKU (Jpn J Nucl Med) 1996; 33: 711–719. (in Japanese)

    CAS  Google Scholar 

  18. Quirce R, Carril JM, Gutierrez-Mendiguchia C, Serrano J, Rabasa JM, Bernal JM. Assessment of the diagnostic capacity of planar scintigraphy and SPECT with99mTc-HMPAO-labelled leukocytes in superficial and deep sternal infections after median sternotomy.Nucl Med Commun 2002; 23: 453–459.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Erika Imai.

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Imai, E., Kaminaga, T., Kawasugi, K. et al. The usefulness of99mTc-hexamethylpropyleneamineoxime white blood cell scintigraphy in a patient with eosinophilic gastroenteritis. Ann Nucl Med 17, 601–603 (2003). https://doi.org/10.1007/BF03006675

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  • DOI: https://doi.org/10.1007/BF03006675

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