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Projections of the central cerebellar nuclei to the intralaminar thalamic nuclei in cats

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Abstract

Projections of the central cerebellar nuclei to the intralaminar thalamic nuclei were studied in cats with the use of light and electron microscopy. Almost all intralaminar nuclei were shown to obtain cerebello-thalamic projections. The entire complex of the central cerebellar nuclei serves as a source of such projections; yet, involvement of different nuclei is dissimilar. Destruction of the central and, especially, caudal regions of the fastigial nucleus evoked in the intralaminar thalamic nuclei degenerative changes in the nerve fibers (from swelling and development of varicosities up to total fragmentation). Pathological phenomena could be noticed in the most caudal regions of the above thalamic nuclear group, including the medial dorsal nucleus. Projections of the cerebellar interpositus nucleus were directed toward nearly the same regions of the intralaminar nuclei; degeneration was more intensive (covered thecentrum medianum) when posterior regions of the interpositus nucleus were destroyed. Destruction of the lateral cerebellar nucleus evoked a similar pattern of pathological changes, but degeneration was also observed in some structures of the ventral and anterior nuclear groups of the thalamus. Electron microscopic examination showed that degeneration of dark and light types developed in the fiber preterminals and terminals. It can be concluded that the central cerebellar nuclei project not only to the ventral complex of the thalamic nuclei, but also to the anterior, medial, and intralaminar nuclear groups (rostral and caudal portions).

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References

  1. M. Ito,The Cerebellum and Neural Control, Raven Press, New York (1984).

    Google Scholar 

  2. V. V. Fanardjyan, “Morphofunctional basis of interaction of the forebrain and cerebellum,”Usp. Fiziol. Nauk,26, 3–17 (1995).

    Google Scholar 

  3. M. Inase, H. Tokuno, A. Nambu, et al., “Origin of thalamocortical projections to the presupplementary motor area (pre-SMA) in the macaque monkey,”Neurosci. Res.,25 217–227 (1996).

    Article  PubMed  CAS  Google Scholar 

  4. Y. Shinoda, S. Kakei, T. Futami, and T. Wannier, “Thalamocortical organization in the cerebello-thalamo-cortical system,”Cerebr. Cortex,3, 421–429 (1993).

    CAS  Google Scholar 

  5. C. Asannuma, W. T. Thach, and E. G. Jones, “Distribution of cerebral terminations and their relation to other afferent termination in the ventral lateral thalamic region of the monkey,”Brain Res. Rev.,5, 237–266 (1983).

    Article  Google Scholar 

  6. C. Asannuma, W. T. Thach, and E. G. Jones, “Anatomical evidence for segregated focal groupings of efferent cells and their terminal ramifications in the cerebellothalamic pathway of the monkey,”Brain Res. Rev.,5, 267–298 (1983).

    Article  Google Scholar 

  7. S. F. Sawyer, J. M. Tepper, and P. M. Groves, “Cerebellar-responsive neurons in the thalamic ventroanterior-ventrolateral complex of rats: light and electron microscopy,”Neuroscience,63, 725–746 (1994).

    Article  PubMed  CAS  Google Scholar 

  8. S. Kakei, J. Yagi, T. Wannier, et al., “Cerebellar and cerebral inputs to corticocortical and corticofugal neurons in areas 5 and 7 in the cat,”J. Neurophysiol.,74 400–412 (1995).

    PubMed  CAS  Google Scholar 

  9. L. Rispal-Padel, C. Harnois, and D. Troiani, “Converging cerebellofugal inputs to the thalamus. Mapping of monosynaptic field potentials in the ventrolateral nucleus of the thalamus,”Exp. Brain Res.,68, 47–58 (1987).

    Article  PubMed  CAS  Google Scholar 

  10. T. Yamamoto, Y. Kishimoto, H. Yoshikawa, and H. Oka, “Intracellular recording from rat thalamic VL neurons: a study combined with intracellular staining,”Exp. Brain Res.,87, 245–253 (1991).

    Article  PubMed  CAS  Google Scholar 

  11. J. Na, S. Kakei, and Y. Shinoda, “Cerebellar input to corticothalamic neurons in layers V and VI in the motor cortex,”Neurosci. Res.,28, 71–91 (1997).

    Article  Google Scholar 

  12. E. P. Lukhanina, “Functional organization of the ventrolateral nucleus of the thalamus,”Neirofiziologiya/Neurophysiology,26, No. 6, 458–472 (1994).

    Google Scholar 

  13. M. Steriade, “Two channels in the cerebellothalamocortical system,”J. Comp. Neurol.,354, 57–70 (1995).

    Article  PubMed  CAS  Google Scholar 

  14. R. L. Faull and J. Carman, “The cerebellofugal projection in thebrachium conjuctivum of the rat. I. The cerebellar ascending pathway,”J. Comp. Neurol.,178, 495–518 (1978).

    Article  PubMed  CAS  Google Scholar 

  15. S. H. C. Hendry, E. G. Jones, and J. Graham, “Thalamic relay nuclei for cerebellar and certain related fiber system in the cat,”J. Comp. Neurol.,185, 679–714 (1979).

    Article  PubMed  CAS  Google Scholar 

  16. W. T. Thach and E. G. Jones, “The cerebellar dentatothalamic connection: terminal field lamellae, rods and somatotopy,”Brain Res.,169, 168–172 (1979).

    Article  PubMed  CAS  Google Scholar 

  17. A. J. Haroian, L. C. Massopust, and P. Young, “Cerebellothalamic projections in the rat: an autoradiographic and degeneration study,”J. Comp. Neurol.,197, 217–236 (1981).

    Article  PubMed  CAS  Google Scholar 

  18. E. G. Jones and R. Y. Leavitt, “Retrograde axonal transport and the demonstration of non-specific projection to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat, monkey,”J. Comp. Neurol.,154, 349–378 (1974).

    Article  PubMed  CAS  Google Scholar 

  19. G. Macchi, M. Bentivoglio, C. D'Atena, et al., “Cortical projection of thalamic intralaminar nuclei restudied by means of HRP retrograde transport,”Neurosci. Lett.,4 121–126 (1977).

    Article  Google Scholar 

  20. G. Macchi and M. Bentivoglio, “The thalamic intralaminar nuclei and cerebral cortex,” in:Cerebral Cortex, Vol. 5, A. Peters and E. G. Jones (eds.), Plenum Press, New York (1986), pp. 355–401.

    Google Scholar 

  21. G. L. Royce, “Cells of origin of corticothalamic projections upon the centromedian and Pf nuclei in the cat,”Brain Res.,258, 11–23 (1989).

    Article  Google Scholar 

  22. K. Itoh and N. Mizuno, “Topographical arrangement of thalamocortical neurons in the centrolateral (CL) nucleus of the cat, with special references to a spino-thalamo-motor cortical path through the CL,”Exp. Brain Res.,30, 471–480 (1977).

    PubMed  CAS  Google Scholar 

  23. M. Bentivoglio, G. Macchi, and A. Albanese, “The cortical projections of the thalamus intralaminar nuclei as studied in cat and rat with the multiple fluorescent retrograde tracing technique,”Neurosci. Lett.,26, 5–10 (1981).

    Article  PubMed  CAS  Google Scholar 

  24. M. Murrey, “Degeneration of some intralaminar thalamic nuclei after cortical removals in the cat,”J. Comp. Neurol.,124, 341–367 (1966).

    Article  Google Scholar 

  25. E. F. S. Kaufman and A. C. Rosenquist, “Efferent projections of the thalamic intralaminar nuclei in the cat,”Brain Res.,335, 257–281 (1985).

    Article  PubMed  CAS  Google Scholar 

  26. E. F. S. Kaufman and A. C. Rosenquist, “Afferent connections of the thalamic intralaminar nuclei in the cat,”Brain Res.,335, 281–297 (1985).

    Article  PubMed  CAS  Google Scholar 

  27. R. S. Snider and W. T. Niemer,A Stereotaxic Atlas of the Cat Brain, Chicago (1961).

  28. R. Fink and L. Haimer, “Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system,”Brain Res.,4 369–374 (1967).

    Article  PubMed  CAS  Google Scholar 

  29. Gu. Samogyi, F. Haidu, and R. Hassler, “EM study of terminal degeneration in the antero-dorsal thalamic nucleus of the cat,”Cell Tissue,182, 455–467 (1977).

    Google Scholar 

  30. T. Sugimoto, N. Mizuno, and K. Itoh, “An autoradiographic study on the terminal distribution of cerebellothalamic fibers in the cat,”Brain Res.,215, 29–47 (1981).

    Article  PubMed  CAS  Google Scholar 

  31. P. Angaut, F. Cicirata, and F. Serapie, “Topographical organization of the cerebello-thalamic projections in the rat. An autoradiographic study,”Neuroscience,15, 389–401 (1985).

    Article  PubMed  CAS  Google Scholar 

  32. H. J. Groenewegen, “Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat related to the mediodorsal prefrontal topography,”Neuroscience,24, 379–455 (1988).

    Article  PubMed  CAS  Google Scholar 

  33. A. A. Airapetyan and L. G. Vaganyan, “Comparative evaluation of the effects of stimulation of the central cerebellar nuclei on the activity of the neurons of specific and non-specific thalamic structures,” in:Neuronal Mechanisms of Integrative Activity of the Cerebellum [in Russian], V. V. Fanardjyan (ed.), Publishing house of Academy of Sciences of Armenian SSR, Yerevan (1979), pp. 166–171.

    Google Scholar 

  34. R. S. Morison and E. W. Dempsey, “Study of thalamo-cortical relations,”Am. J. Physiol.,135 281–292 (1942).

    Google Scholar 

  35. V. V. Fanardjyan, “Recruitment reaction in the brain cortex at stimulation of the cerebellum,”Fiziol. Zh. SSSR,49, 1059–1066 (1963).

    Google Scholar 

  36. V. V. Fanardjyan,Regulatory Mechanisms of Ascending Influences of the Cerebellum [in Russian], Publishing Hause of Academy of Sciences of Armenian SSR, Yerevan (1966).

    Google Scholar 

  37. A. I. Karamian, V. V. Fanardjian, and A. A. Kosareva, “The functional and morphological evolution of the cerebellum and its role in behavior,” in:Neurobiology of Cerebellar Evolution and Development, R. Llinas (ed.), Am. Med. Assoc., Chicago (1969), pp 639–673.

    Google Scholar 

  38. K. Sasaki, Y. Matsuda, and N. Mizuno, “Distribution of cerebellar-induced responses in the cerebral cortex,”Exp. Neurol.,39, 342–354 (1973).

    Article  PubMed  CAS  Google Scholar 

  39. K. Sasaki, H. P. Staunton, and G. Dieckmann, “Characteristic feature of augumenting and recruiting responses in the cerebral cortex,”Exp. Neurol.,26, 369–392 (1970).

    Article  PubMed  CAS  Google Scholar 

  40. K. Sasaki, Y. Matsuda, H. Oka, and N. Mizuno, “Thalamo-cortical projections for recruiting responses and spindling-like responses in the parietal cortex,”Exp. Brain Res.,22, 87–96 (1975).

    Article  PubMed  CAS  Google Scholar 

  41. V. V. Fanardzjan,Das klainkhirn und Unspezifische thalamokortikale System, Vol. 3, Wissenschaft. Zeitsch. Universit. Leipzig (1966).

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  1. Orbeli Institute of Physiology, National Academy of Sciences of Armenia, Yerevan, Armenia

    A. B. Melik-Musyan & V. V. Fanardjyan

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  1. A. B. Melik-Musyan
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  2. V. V. Fanardjyan
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Melik-Musyan, A.B., Fanardjyan, V.V. Projections of the central cerebellar nuclei to the intralaminar thalamic nuclei in cats. Neurophysiology 30, 39–47 (1998). https://doi.org/10.1007/BF02463111

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