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Effects of chronic marijuana use on human cognition

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Abstract

Impairments of human cognition and learning following chronic marijuana use are of serious concern, but have not been clearly demonstrated. To determine whether such impairments occurred, this study compared performance of adult marijuana users and non-users (N=144 andN=72, respectively) matched on intellectual functioning before the onset of drug use, i.e., on scores from standardized tests administered during the fourth grade of grammar school (Iowa Tests of Basic Skills). Subjects were given the twelfth grade versions of these tests (Iowa Tests of Educational Development) and other, computerized cognitive tests in successive test sessions. “Heavy” marijuana use (defined by use seven or more times weekly) was associated with deficits in mathematical skills and verbal expression in the Iowa Tests of Educational Development and selective impairments in memory retrieval processes in Buschke's Test. The retrieval impairments were restricted to words that were easy to visualize. Impairments depended on the frequency of chronic marijuana use, i.e., “light” and “intermediate” marijuana use (defined by use one to four and five to six times weekly, respectively) were not associated with deficits. Intermediate use was associated with superior performance in one condition (“fuzzy” concepts) of a Concept Formation test.

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References

  • Barnett G, Licko V, Thompson T (1985) Behavioral pharmacokinetics of marijuana. Psychopharmacology 85:51–56

    Google Scholar 

  • Berchou R, Block RI (1983) Use of computerized psychomotor testing in determining CNS effects of drugs. Percept Mot Skills 57:691–700

    Google Scholar 

  • Block RI, Berchou R (1984) Alprazolam and lorazepam effects on memory acquisition and retrieval processes. Pharmacol Biochem Behav 20:233–241

    Google Scholar 

  • Block RI, Wittenborn JR (1984) Marijuana effects on visual imagery in a paired-associate task. Percept Mot Skills 58:759–766

    Google Scholar 

  • Block RI, Farnham S, Braverman K, Hinrichs JV, Ghoneim MM (1989) Norms for free associations and five types of constrained associations. Psychol Rep 64:1065–1066

    Google Scholar 

  • Block RI, Farinpour R, Braverman K (1992) Effects of marijuana smoking on cognition and their relationship to smoking technique. Pharmacol Biochem Behav (in press)

  • Bowman M, Pihl RO (1973) Cannabis: psychological effects of chronic heavy use: a controlled study of intellectual functioning in chronic users of high potency cannabis. Psychopharmacologia 29:159–170

    Google Scholar 

  • Buschke H (1973) Selective reminding for analysis of memory and learning. J Verb Learn Verb Behav 12:543–550

    Google Scholar 

  • Carlin AS, Trupin EW (1977) The effect of long-term chronic marijuana use on neuropsychological functioning. Int J Addict 12:617–624

    Google Scholar 

  • Chait LD (1990) Subjective and behavioral effects of marijuana the morning after smoking. Psychopharmacology 100:328–333

    Google Scholar 

  • Chait LD, Fischman MW, Schuster CR (1985) ‘Hangover’ effects the morning after marijuana smoking. Drug Alcohol Depend 15:229–238

    Google Scholar 

  • Culver CM, King FW (1974) Neuropsychological assessment of undergraduate marihuana and LSD users. Arch Gen Psychiatry 31:707–711

    Google Scholar 

  • Entin EE, Goldzung PJ (1973) Residual effects of marihuana usage on learning and memory. Psychol Rec 23:169–178

    Google Scholar 

  • Freund RJ, Littell RC (1985) SAS for linear models: a guide to the ANOVA and GLM procedures. SAS Institute, Cary, North Carolina

    Google Scholar 

  • Gianutsos R, Litwack AR (1976) Chronic marijuana smokers show reduced coding into long-term storage. Bull Psychon Soc 7:277–279

    Google Scholar 

  • Grant I, Rochford J, Fleming T, Stunkard A (1973) A neuropsychological assessment of the effects of moderate marihuana use. J Nerv Ment Dis 156:278–280

    Google Scholar 

  • Heishman SJ, Huestis MA, Henningfield JE, Cone EJ (1990) Acute and residual effects of marijuana: profiles of plasma THC levels, physiological, subjective, and performance measures. Pharmacol Biochem Behav 37:561–565

    Google Scholar 

  • Hieronymus AN, Lindquist EF, Hoover HD (1982) Manual for school administrators, Iowa tests of basic skills. Riverside Publishing, Chicago

    Google Scholar 

  • Hollingshead AB (1949) Elmtown's youth: the impact of social classes on adolescents. Wiley, New York

    Google Scholar 

  • Iowa Testing Programs (1987a) ITED examiner's manual, directions for testing, Iowa tests of educational development, forms X-8 and Y-8. Iowa Testing Programs, The University of Iowa, Iowa City, Iowa

    Google Scholar 

  • Iowa Testing Programs (1987b) ITED manual for teachers, administrators, and counselors, Iowa tests of educational development, forms X-8 and Y-8. Iowa Testing Programs, The University of Iowa, Iowa City, Iowa

    Google Scholar 

  • Janowsky DS, Meacham MP, Blaine JD, Schoor M, Bozzetti LP (1976) Marijuana effects on simulated flying ability. Am J Psychiatry 133:384–388

    Google Scholar 

  • Johnston LD, Bachman JG, O'Malley PM (1981) Student drug use in America: 1975–1981. National Institute on Drug Abuse, Rockville, Maryland

    Google Scholar 

  • Leirer VO, Yesavage JA, Morrow DG (1989) Marijuana, aging, and task difficulty effects on pilot performance. Aviat Space Environ Med 60:1145–1152

    Google Scholar 

  • Leirer VO, Yesavage JA, Morrow DG (1991) Marijuana carry-over effects on aircraft pilot performance. Aviat Space Environ Med 62:221–227

    Google Scholar 

  • Martin RC, Caramazza A (1980) Classification in well-defined and ill-defined categories: evidence for common processing strategies. J Exp Psychol [Gen] 109:320–353

    Google Scholar 

  • Mendhiratta SS, Wig NN, Verma SK (1978) Some psychological correlates of long-term heavy cannabis users. Br J Psychiatry 132:482–486

    Google Scholar 

  • Miller JR, Kintsch W (1980) Readability and recall of short prose passages: a theoretical analysis. J Exp Psychol [Hum Learn] 6:335–354

    Google Scholar 

  • Miller L, Cornett T, McFarland D (1978) Marijuana: an analysis of storage and retrieval deficits in memory with the technique of restricted reminding. Pharmacol Biochem Behav 8:327–332

    Google Scholar 

  • National Institute on Drug Abuse (1982) Marijuana and youth: clinical observations on motivation and learning. National Institute on Drug Abuse, Rockville, Maryland

    Google Scholar 

  • Page JB, Fletcher J, True WR (1988) Psychosociocultural perspectives on chronic cannabis use: the Costa Rican follow-up. J Psychoactive Drugs 20:57–65

    Google Scholar 

  • Paivio A, Yuille JC, Madigan SA (1968) Concreteness, imagery, and meaningfulness values for 925 nouns. J Exp Psychol 76:1–25

    Google Scholar 

  • Parrott AC (1991a) Performance tests in human psychopharmacology (1): test reliability and standardization. Hum Psychopharmacol 6:1–9

    Google Scholar 

  • Parrott AC (1991b) Performance tests in human psychopharmacology (2): content validity, criterion validity, and face validity. Hum Psychopharmacol 6:91–98

    Google Scholar 

  • Parrott AC (1991c) Performance tests in human psychopharmacology (3): construct validity and test interpretation. Hum Psychopharmacol 6:197–207

    Google Scholar 

  • Rafaelsen L, Christrup H, Bech P, Rafaelsen OJ (1973) Effects of cannabis and alcohol on psychological tests. Nature 242:117–118

    Google Scholar 

  • Rafaelsen OJ, Bech P, Christiansen J, Christrup H, Nyboe J, Rafaelsen L (1973) Cannabis and alcohol: effects on simulated car driving. Science 179:920–923

    Google Scholar 

  • Reed SK (1972) Pattern recognition and categorization. Cognit Psychol 3:382–407

    Google Scholar 

  • Robins LN, Helzer JE (1985) Diagnostic interview schedule (DIS) version III-A. Washington University School of Medicine, St Louis

    Google Scholar 

  • Rosch E, Mervis CB (1975) Family resemblances: studies in the internal structure of categories. Cognit Psychol 7:573–605

    Google Scholar 

  • Rosenbaum PR, Rubin DB (1985) Constructing a control group using multivariate matched sampling methods that incorporate the propensity score. Am Statist 39:33–38

    Google Scholar 

  • Rubin V, Comitas L (1975) Ganja in Jamaica: a medical anthropological study of chronic marihuana use. Mouton, The Hague

    Google Scholar 

  • Schwartz RH, Gruenewald PJ, Klitzner M, Fedio P (1989) Short-term memory impairment in cannabis-dependent adolescents. Am J Dis Child 143:1214–1219

    Google Scholar 

  • Science Research Associates (1972) Interpretative manual, short test of educational ability, STEA, levels 3–5. Science Research Associates, Chicago

    Google Scholar 

  • Science Research Associates (1974) Examiner's manual, STEA, short test of educational ability, levels 3–5. Science Research Associates, Chicago

    Google Scholar 

  • Science Research Associates (1981) ITED, Iowa tests of educational development, forms X5 and Y5, technical report addendum: 1978 standardization. Science Research Associates, Chicago

    Google Scholar 

  • Soueif MI (1971) The use of cannabis in Egypt: a behavioural study. Bull Narc 23:17–28

    Google Scholar 

  • Soueif MI (1975) Chronic cannabis users: further analysis of objective test results. Bull Narc 27:1–26

    Google Scholar 

  • Soueif MI (1976) Some determinants of psychological deficits associated with chronic cannabis consumption. Bull Narc 28:25–42

    Google Scholar 

  • Stefanis C, Boulougouris J, Liakos A (1976) Clinical and psychophysiological effects of cannabis in long-term users. In: Braude MC, Szara S (eds) Pharmacology of marihuana, vol 2. Raven Press, New York, pp 659–665

    Google Scholar 

  • Tart CT (1971) On being stoned: a psychological study of marijuana intoxication. Science and Behavior Books, Palo Alto, California

    Google Scholar 

  • Varma VK, Malhotra AK, Dang R, Das K, Nehra R (1988) Cannabis and cognitive functions: a prospective study. Drug Alcohol Depend 21:147–152

    Google Scholar 

  • Weckowicz TE, Janssen DV (1973) Cognitive functions, personality traits, and social values in heavy marijuana smokers and non-smoker controls. J Abnorm Psychol 81:264–269

    Google Scholar 

  • Weckowicz TE, Collier G, Spreng L (1977) Field dependence, cognitive functions, personality traits, and social values in heavy cannabis users and nonuser controls. Psycho Rep 41:291–302

    Google Scholar 

  • Wig NN, Varma VK (1977) Patterns of long-term heavy cannabis use in north India and its effects on cognitive functions: a preliminary report. Drug Alcohol Depend 2:211–219

    Google Scholar 

  • Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill, New York

    Google Scholar 

  • Yesavage JA, Leirer VO, Denari M, Hollister LE (1985) Carry-over effects of marijuana intoxication on aircraft pilot performance: a preliminary report. Am J Psychiatry 142:1325–1329

    Google Scholar 

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Block, R.I., Ghoneim, M.M. Effects of chronic marijuana use on human cognition. Psychopharmacology 110, 219–228 (1993). https://doi.org/10.1007/BF02246977

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  • DOI: https://doi.org/10.1007/BF02246977

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