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The Warburg hypothesis fifty years later

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References

  • Aisenberg,A.C.: The glycolysis and respiration of tumors. London-New York: Academic Press 1961

    Google Scholar 

  • Burk,D.: Cold spring harbor symposia Quant. Biol. 7, 420 (1939)

    Google Scholar 

  • Cristofalo,V.J., Kritchevsky,D.: Respiration and glycolysis in the human diploid cell strain WI-38. J. cell. Physiol. 67, 125–132 (1966)

    Google Scholar 

  • Eagle,H., Barban,S., Levy,M., Schultz,H.O.: The utilization of carbohydrates by human cell cultures. J. biol. Chem. 233, 551–558 (1958)

    Google Scholar 

  • Gosalvez,M., Perez-Garcia,J., Weinhouse,S.: Competition for ADP between pyruvate kinase and mitochondrial oxidative phosphorylation as a control mechanism in glycolysis. Europ. J. Biochem. 46, 133–140 (1974)

    Google Scholar 

  • Gregg,C.T.: Some aspects of the energy metabolism of mammalian cells. In: Growth, nutrition and metabolism of cells in culture. Vol. 1 (eds. V.J. Cristofalo, and G.H. Rothblatt) pp. 83–136 (1972)

  • Gullino,P.M., Grantham,F.H., Courtney,A.H., Lasonczy,I.: Relationship between oxygen and glucose consumption by transplanted tumors in vivo. Cancer Res. 27, 1041–1052 (1967)

    Google Scholar 

  • Hakomori,S.: Glycolipids of tumor cell membranes. Advanc. Cancer Res. 18, 265–315 (1973)

    Google Scholar 

  • Hatanaka,M.: Transport of sugars in tumor cell membranes. Biochim. biophys. Acta (Amst.) 355, 77–105 (1974)

    Google Scholar 

  • Krebs,H.A.: The Pasteur Effect. In: Essays in Biochemistry, Vol. 8 (eds. P.N.Campbell and F.Dickens), pp. 1–34. London-New York: Academic Press 1972

    Google Scholar 

  • Malmgren,R.A., Flanigan,C.C: Localization of the vegetative form of Clostridium tetani in mouse tumors following intravenous spore administration. Cancer Res. 15, 473–478 (1955)

    Google Scholar 

  • Morris,H.P., Meranze,D.R.: Induction and some characteristics of “Minimal Deviation” hepatomas. Recent results in Cancer Research, Vol. 44, pp. 104–114. Berlin, Heidelberg, New York: Springer 1975

    Google Scholar 

  • Olson,R.E.: Oxidation of C14-labeled carbohydrate intermediates in tumor and normal tissue. Cancer Res. 11, 571–584 (1951)

    Google Scholar 

  • Racker,E.: Mechanisms in bioenergetics. London-New York: Academic Press 1965

    Google Scholar 

  • Scholnick,P., Lang,D., Racker,E.: Regulatory mechanisms in carbohydrate metabolism IX. Stimulation of aerobic glycolysis by energy-linked ion transport and inhibition by Dextran sulfate. J. biol. Chem. 248, 5175–5182 (1973)

    Google Scholar 

  • Warburg,O.: Über den Stoffwechsel der Tumoren, Berlin: Springer 1926. Translated: The metabolism of tumors. London: Arnold Constable 1930

    Google Scholar 

  • Warburg,O.: Oxygen, the creator of differentiation. In: Current aspects of biochemical energetics (eds. N.O.Kaplan and E.Kennedy) pp. 103–109. London-New York: Academic Press 1966

    Google Scholar 

  • Weber,G.: Ordered and specific pattern of gene expression in differentiating and in neoplastic cells. Proceedings of the 4th International Symposium of The Princess Takamatsu. Cancer Research Fund, Tokyo, 1973, pp. 151–180. Tokyo: University Park Press 1974

    Google Scholar 

  • Weinhouse,S.: Studies on the fate of isotopically labeled metabolites in the oxidative metabolism of tumors. Cancer Res. 11, 585–591 (1951)

    Google Scholar 

  • Weinhouse,S.: Oxidative metabolism of neoplastic tissues. Advanc. Cancer Res. 3, 269–325 (1956)

    Google Scholar 

  • Weinhouse,S.: Glycolysis, respiration and anomalous gene expression in experimental hepatomas. Cancer Res. 32, 2007–2016 (1972)

    Google Scholar 

  • Wenner,C.E.: Regulation of energy metabolism in normal and tumor tissues. In: Cancer: a comprehensive treatise (ed. F.F.Becker) pp. 389–403. New York: Plenum Press 1975

    Google Scholar 

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Authors and Affiliations

  1. The Fels Research Institute and Department of Biochemistry, Temple University School of Medicine, 19140, Philadelphia, Pennsylvania, USA

    S. Weinhouse

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  1. S. Weinhouse
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“Cancer Research and Clinical Oncology” publishes in loose succession “Editorials” and “Guest Editorials” on actual and/or controversial problems in experimental and clinical oncology. These contributions represent exclusively the personal opinion of the author. The Editors Die „Zeitschrift für Krebsforschung und Klinische Onkologie“ bringt in zwangloser Folge „Editorials“ zu aktuellen und/oder kontroversen Problemen der experimentellen und klinischen Onkologie. Diese Beiträge geben ausschließlich die persönliche Meinung des Autors wieder. Die Herausgeber

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Weinhouse, S. The Warburg hypothesis fifty years later. Z. Krebsforsch. 87, 115–126 (1976). https://doi.org/10.1007/BF00284370

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