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B Cell Lymphoma

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B Cells in Immunity and Tolerance

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1254))

Abstract

B cell development and activation are accompanied by dynamic genetic alterations including V(D)J rearrangements and immunoglobulin-gene somatic hypermutation and class-switch recombination. Abnormalities in these genetic events can cause chromosomal translocations and genomic mutations, leading to altered expression and function of genes involved in B cell survival or proliferation and consequently B lymphomagenesis. In fact, B cell lymphoma accounts for 95% of the lymphomas. In this chapter, we summarize the morphology, immunophenotypes, clinical features, genetic defects that cause the malignancies, treatments, and prognosis of the most prevalent types of B cell lymphomas, including typical precursor B cell malignance (B-ALL/LBL) and mature B cell lymphoma (Hodgkin lymphoma and B cell non-Hodgkin lymphoma).

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Acknowledgements

We thank Luming Zhang for secretarial assistance, Fudan University Animal Facility for maintaining the mice and the members in Wang Lab for helpful suggestions. This work was supported by the Major Research Plan of the National Natural Science Foundation of China (91942302 to J.Y.W.), the National Key R & D Plan of the Ministry of Science and Technology (SQ2019YFE0100600 to J.Y.W.), the National Natural Science Foundation of China (81571529 and 31870898 to J.Y.W), Projects of International Cooperation and Exchanges NSFC (81811540035 to J.Y.W.), a grant-in-aid for scientific research (C) from Japan Society for the Promotion of Science (17K08878 to J.Y.W) and a grant for the Innovative Research Team of High-Level Local Universities in Shanghai.

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  1. Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China

    Xin Meng, Qing Min & Ji-Yang Wang

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  1. Xin Meng
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    Ji-Yang Wang

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Meng, X., Min, Q., Wang, JY. (2020). B Cell Lymphoma. In: Wang, JY. (eds) B Cells in Immunity and Tolerance. Advances in Experimental Medicine and Biology, vol 1254. Springer, Singapore. https://doi.org/10.1007/978-981-15-3532-1_12

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