Regular ArticleThe Central Region of Gadd45 Is Required for Its Interaction with p21/WAF1
References (43)
- et al.
Cell
(1992) - et al.
Cell
(1993) - et al.
J. Biol. Chem.
(1994) - et al.
Cell
(1998) - et al.
Curr. Opin. Cell Biol.
(1996) - et al.
Semin. Immunol.
(1993) Cell
(1994)- et al.
Science
(1994) - et al.
Proc. Natl. Acad. Sci. USA
(1992) - et al.
Cancer Res.
(1994)
Genes Dev.
Cell
Proc. Natl. Acad. Sci. USA
Mol. Cell. Biol.
DNA Cell Biol.
Mol. Cell. Biol.
Mol. Cell. Biol.
Science
Oncogene
Oncogene
Cell
Cited by (57)
Correlation between the radiation responses of fibroblasts cultured from individual patients and the risk of late reaction after breast radiotherapy
2016, Cancer LettersCitation Excerpt :However, expression of the endogenous cdk inhibitor p21/CDKN1A, which is a major transcriptional target of p53 and part of the stress-induced G1/S cell-cycle checkpoint, was not associated with late reaction. Instead, we speculate that another p53 transcriptional target GADD45, which plays important roles in genomic stability and differentiation [55–57], might be involved, in which case it might target the G2/M rather than the G1/S checkpoint [58]. In conclusion, we have found a small but significant increase in the number of residual DSBs and a consistently higher fraction of p53-positive cells without irradiation, as well as 2 h and 6 d after in vitro irradiation of fibroblasts from RT-sensitive versus RT-resistant patients.
Inhibitory effect of isoamericanol A from Jatropha curcas seeds on the growth of MCF-7 human breast cancer cell line by G2/M cell cycle arrest
2016, HeliyonCitation Excerpt :In human breast cancer cell lines, such as MDA-MB-231 or MCF-7, BTG2 mRNA expression is generally undetectably low [24], and it is one of the tumor suppressor genes that inactivates the cyclin B1/CDK1 complex [25, 26]. GADD45A and p21 bind to CDK1, resulting in dissociation of the cyclin B/CDK1 complex and eventually induction of cell cycle arrest at G2/M [18, 27, 28]. As clearly shown in our data of cell cycle analysis (Fig. 3), western blot analysis (Fig. 5) and real-time PCR (Fig. 6), IAA treatment initiated G2/M arrest on MCF-7 by the increased expression of BTG2, p21, and GADD45A.
Gadd45 proteins: Relevance to aging, longevity and age-related pathologies
2012, Ageing Research ReviewsCitation Excerpt :This important regulator of cell cycle is deeply involved in cellular senescence, cancer, atherosclerosis, and diabetes (Chang et al., 2000). Its interaction with Gadd45 was shown to inhibit cell growth and as such, could be part of p21-mediated tumor suppressor activity (Zhao et al., 2000). Apart from direct protein–protein interactions, there are numerous regulatory links between Gadd45 and well known players in ARDs, such as p53, p38, JNK, FOXO, SIRT1, HDAC, and others (see previous sections and Fig. 3).
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