Brief CommunicationEffect of Short-Term Treatment with Pivalic Acid Containing Antibiotics on Serum Carnitine Concentration - A Risk Irrespective of Age
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Hypoglycemia associated with pivalate-conjugated antibiotics in young children: A retrospective study using a medical and pharmacy claims database in Japan
2020, Journal of Infection and ChemotherapyCitation Excerpt :However, we found that even use of PCAs for ≤7 days significantly increased the incidence of hypoglycemia (Table 3). Previous studies found that short-term administration of pivampicillin and pivmecillinam, pivoxil-conjugated penicillins, resulted in a reduction of the mean serum carnitine concentration to 15% of the pretreatment value in seven girls over a long period [20], and 7-day use of pivmecillinam reduced the serum carnitine by about 30% [21]. Because 7 days of PCA treatment can cause hypocarnitinemia, it seems plausible that hypoglycemia following hypocarnitinemia occurs within 7 days after prescription of PCAs.
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