MR566A and MR56.6B, New Melanin Synthesis Inhibitors Produced by Trichoderma harzianum I. Taxonomy, Fermentation, Isolation and Biological Activities

CHOONG HWAN LEE; MYUNG CHUL CHUNG; HO JAE LEE; KYUNG SOOK BAE; YUNG HEE KHO

doi:10.7164/antibiotics.50.469

MR566A and MR56.6B, New Melanin Synthesis Inhibitors Produced by Trichoderma harzianum

I. Taxonomy, Fermentation, Isolation and Biological Activities

CHOONG HWAN LEE, MYUNG CHUL CHUNG, HO JAE LEE, KYUNG SOOK BAE, YUNG HEE KHO

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JOURNAL FREE ACCESS

1997 Volume 50 Issue 6 Pages 469-473

DOI https://doi.org/10.7164/antibiotics.50.469

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Abstract

New melanin synthesis inhibitors (MR566A and B) and six related known isocyanocyclopentenes were isolated from the fermentation broth of Trichoderma harzianum. The IC₅₀ values of MR566A and B against mushroom tyrosinase were 1.72 and 47μM, respectively. They inhibited melanin biosynthesis in B16 melanoma cells with MIC values of 0.1 and 2.2μM, respectively. Also isolated from the same culture extract of T. harzianum was a new oxazole (MR93B), which showed no inhibitory activity against mushroom tyrosinase at a concentration of 1.000μg/ml.

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