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Micronutrient Interventions on Cognitive Performance of Children Aged 5-15 Years in Developing Countries

開發中國家5-15歲孩童在微量營養素介入後的認知功能表現

摘要


據估計,全球有超過2億的幼童由於營養不足導致認知功能發育遲緩。目前已有許多研究,致力於評估微量營養素的補充,對於嬰兒、幼童及學齡前兒童成長及認知發展的影響。然而,微量營養素對於較大兒童認知表現的研究則有限。本文旨在提供關於微量營養素介入對於開發中國家5-15歲孩童認知影響的最新研究結果訊息。自2000年開始,共有13篇隨機對照試驗結果發表。大多數研究評估微量營養素強化食品對於不同認知功能領域的影響。被評估的主要微量營養素包括鐵、鋅、碘及維生素A。此次回顧發現,微量營養素補充的介入研究,在兒童的智力、長期心智功能及在校成績的影響結果並不一致。只有在短期記憶的部分,具有正向且較一致性的研究結果。整體而言,微量營養素對於較大兒童認知表現的影響,仍不明確。有鑑於,營養對於認知發育的效應越來越受重視,因此有必要建立適合各族群以及具足夠敏感度的分析工具,以測量最有可能受到欲研究的營養素影響之認知表現。

並列摘要


It is estimated that more than 200 million young children worldwide fail to reach their potential in cognitive development owing to undernutrition. Numerous studies have assessed the effects of micronutrient supplementation on growth and cognitive development in infants, toddlers and preschoolers. However, micronutrient interventions on the cognitive performance of older children are limited. This article seeks to provide an update on micronutrient interventions and cognitive outcomes among children aged 5-15 years in developing countries. A total of 13 randomized controlled trials published since 2000 were identified. Majority of these studies assessed the effects of micronutrient-fortified foods on various domains of cognitive function. Among key micronutrients assessed were iron, zinc, iodine and vitamin A. This review found a lack of consistency in the impact of micronutrient supplementation on intelligence, long term mental functions and school examination grades of the children. A beneficial effect of micronutrient supplementation on short term memory was more consistently reported. Overall, the evidence from this review for the impact of micronutrients on cognitive performance in older children remains equivocal. In light of the growing interest on the influence of nutrition on cognition, it is important that culturally-appropriate and sufficiently sensitive assessment tools be used for measuring the desired cognitive outcomes that are most likely to be affected by the nutrients under study.

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