An amorphous matrix of sugars, which are frequently used in the pharmaceutical and drug industries, is often compressed into a tablet to facilitate handling. Herein, the influences of compression on physicochemical properties of an amorphous sugar matrix are reviewed in this paper. Amorphous sugar samples, prepared by freeze-drying, were compressed at 0～667 MPa and rehumidified at given relative humidities. The macro structure, true density, water sorption （including interaction states of sorbed water）, glass transition temperature, crystallization characteristics, and protein stabilizing effects of compressed samples were analyzed and compared to those for uncompressed ones.