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    Korean J Urol. 2009 Mar;50(3):241-245. Korean.
    Published online Mar 25, 2009.
    https://doi.org/10.4111/kju.2009.50.3.241
    Copyright © The Korean Urological Association, 2009
    Original Article

    A Study of Minimal Change in Nocturia Affecting Quality of Life

    Jong Baek Shim, Seong Ho Lee and Hayoung Kim
      • Department of Urology, School of Medicine, Hallym University, Seoul, Korea.
    • Correspondence to: Hayoung Kim. Department of Urology, School of Medicine, Hallym University, 445, Gil-dong, Gangdong-gu, Seoul 134-701, Korea. TEL: 02-2224-2293, FAX: 02-2224-2338, Email: hykim@hallym.or.kr
    Received November 26, 2008; Accepted February 09, 2009.

    Abstract

    Purpose

    It is well known that nocturia is a bothersome symptom that affects the quality of life (QoL). However, it is not known how much of a decrease in nocturnal frequency is needed to improve the QoL. We determined the minimal change in nocturnal frequency affecting the QoL of patients with nocturia.

    Materials and Methods

    A total of 87 patients with BPH and nocturia were treated with α-blocker and desmopressin for 8 weeks. Considering that the minimal clinically important change (MCIC) is different according to the baseline value, we divided the patients into two groups (group I, II). Group I had mild to moderate nocturia with voiding <4 times per night, and Group II had severe nocturia with voiding ≥4 times per night. Voiding diaries and King's Health Questionnaires (KHQs) were evaluated before and after treatment. To determine the minimal change in nocturia affecting the QoL, statistical analysis was performed by Student's t-test and ANOVA test with the change in KHQ score according to decreased numbers of nocturnal frequency.

    Results

    Groups I and II had 35 and 52 patients, respectively. The minimal decrease in nocturnal frequency associated with a statistically significant decrease in sleep/energy domain scores was 1 time in Group I and 2 times in Group II.

    Conclusions

    These data show that decreases in nocturia of at least 1 time in patients with mild to moderate nocturia (<4 times/night) and of 2 times in patients with severe nocturia (≥4 times/night) are needed to improve the QoL.

    Keywords
    Nocturia; Quality of life

    Figures

    Fig. 1
    King's Health Questionnaires (KHQ) sleep/energy domain scores according to the number of times of nighttime voiding before treatment. The KHQ sleep/energy domain scores in patients with nocturia of ≥4 times/night were significantly higher than those in patients with nocturia of <4 times/night.

    Tables

    Table 1
    Characteristics of the patients in each group

    Table 2
    Changes in the KHQ sleep/energy domain score according to the number of times decrease in nocturia

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    MeSH Terms
    Deamino Arginine Vasopressin
    Humans
    Nocturia
    Quality of Life
    Metrics
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