Paper Titles

Magnetic Nanoparticles as Drug Carriers: Review
p.1

Carbon-Based Nanomaterials for Drugs Sensing: A Review
p.13

A Review on PEO Based Solid Polymer Electrolytes (SPEs) Complexed with LiX (X=Tf, BOB) for Rechargeable Lithium Ion Batteries
p.41

Photodegradation of Reactive Red 141 and Reactive Yellow 105 Dyes Using Prepared TiO₂ Nanoparticles
p.65

V₂O₅-Photocatalyzed Oxidation of Diphenylamine
p.81

Enhancement of CdO/ZnO/PVC Nanocomposites Behavior on Photo-Catalytic Degradation of Congo-Red Dye under UV Light Irradiation
p.91

A Comparative Study on the Role of Precursors of Graphitic Carbon Nitrides for the Photocatalytic Degradation of Direct Red 81
p.101

Synthesis of Zn Doped CdSe Quantum Dots via Inverse Micelle Technique
p.115

HomeMaterials Science ForumMaterials Science Forum Vol. 807Magnetic Nanoparticles as Drug Carriers: Review

Magnetic Nanoparticles as Drug Carriers: Review

Article Preview

Abstract:

Magnetic nanoparticles are made up of magnetic elements such as iron, nickel, cobalt and their oxides. Their unique physical and chemical properties, biocompatibility and their ability to be manipulated by external magnetic fields have made them as popular drug carriers in recent years. They offer various advantages such as ability to carry drugs to the desired areas in the body, and the ability to release the drugs in a controlled manner which in turn help in reducing side effects to other organs and in providing correct dosage of drugs. However, the complexity of the drug delivery system is a challenge in further improving the efficiency of magnetic nanoparticle drug delivery. In order to overcome this challenge, computational tools help in understanding the complexity of the drug delivery process and to design magnetic nanoparticles which are more efficient in drug delivery. In this chapter we propose to review various properties of magnetic nanoparticles, applications of magnetic nanoparticles as drug carriers, challenges in using them for drug delivery, various computational tools which aid in modeling magnetic nanoparticle drug delivery and in designing magnetic nanoparticles for efficient targeted drug delivery.

You might also be interested in these eBooks

Multi-Functional Nanoscale Materials and their Potential Applications

Info:

Periodical:

Materials Science Forum (Volume 807)

Pages:

1-12

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.807.1

Citation:

Cite this paper

Online since:

November 2014

Authors:

R. Rajeswari*, R. Jothilakshmi

Keywords:

Computational Modeling, Drug Delivery, Magnetic Nanoparticles

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

* - Corresponding Author

[1] V. Wagner, A. Dullaart, A-K. Boch and A. Zweck, The emerging nanomedicine landscape, Nature Biotechnology, 24(10), (2006), 1211-1217.

DOI: 10.1038/nbt1006-1211

[2] J. H. Park, G. Saravanakumar, K. Kim and I. C. Kwon, Targeted delivery of low molecular drugs using chitosan and its derivatives, Advanced Drug Delivery Reviews, 62(10), (2010), 28-41.

DOI: 10.1016/j.addr.2009.10.003

[3] J. Dobson, Magnetic nanoparticles for drug delivery, Drug Development Research, 67, (2006), 55-60.

[4] M. Arruebo, R. F. Pacheco, M. R. Ibarra and J. Santamaria, Magnetic nanoparticles for drug delivery, Nanotoday, 2(3), (2007), 22-32.

[5] A. Z. Wilczewska, K. Niemirowicz, K. H. Markrewicz and H. Car, Nanoparticles as drug delivery systems, Pharmacological Reports, 64, (2012), 1020-1037.

DOI: 10.1016/s1734-1140(12)70901-5

[6] S. M. Musa (Ed. ), Computational Nanotechnology Modeling and Applications with MATLAB, CRC Press, (2012).

[7] S. Tamar, Molecular Modeling and Simulation: An Interdisciplinary Guide, Springer: New York, (2002).

[8] C. A. Lipinski, F. Lombardo, B. W. Dominy and P. J. Feeney, Experimental and computational approaches to estimate stability and permeability in drug discovery and development settings, Advanced Drug Delivery Reviews, 46, (2001), 3-26.

DOI: 10.1016/j.addr.2012.09.019

[9] N. Haddish-Berhane, J. L. Rickus, and K. Haghighi, The role of multiscale computational approaches for rational design of conventional and nanoparticle oral drug delivery Systems, International Journal of Nanomedicine, 2, (2007), 315-331.

[10] L. Huynh, C. Neale, R. Pomes and C. Allen, Computational approaches to the rational design of nanoemulsions, polymeric micelles and dendrimers for drug delivery, Nanomedicine, 8, (2012), 20-26.

DOI: 10.1016/j.nano.2011.05.006

[11] J. Panyam and V. Labhasehvar, Biodegradable nanoparticles for drug and gene delivery to cells and tissue, Advanced Drug Delivery Reviews, 55, (2003), 329-347.

DOI: 10.1016/s0169-409x(02)00228-4

[12] V. J. Mohanraj and Y. Chen, Nanoparticles - a review, Tropical Journal of Pharmaceutical Research, 5(1), (2006), 561-573.

[13] H. M. Redhead, S. S. Davis and L. Illum, drug delivery in poly (lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterization and in vivo evaluation, Journal of Controlled Release, 70, (2001).

DOI: 10.1016/s0168-3659(00)00367-9

[14] A. K. Gupta and A. S. G. Curtis, Surface modified superparamagnetic nanoparticles for drug delivery: interaction studies with human fibroblasts in culture, Journal of Materials Science: Materials in Medicine, 15, (2004), 493-496.

DOI: 10.1023/b:jmsm.0000021126.32934.20

[15] A. J. Cole, V. C. Yang, and A. E. David, Cancer theranostics: the rise of targeted magnetic nanoparticles, Trends in Biotechnology. 29, (2011), 323-332.

DOI: 10.1016/j.tibtech.2011.03.001

[16] L. Grislain, P. Couvreur, V. Lenaerts, M. Ronald, D. Deprez-Decampeneere and P. Speiser, Pharmacokinetics and distribution of a biodegradable drug-carrier, International Journal of Pharmaceutics, 15, (1983), 335-345.

DOI: 10.1016/0378-5173(83)90166-7

[17] Y. Geng, P. Dalhaimer, S. S. Cai, R. Tsai, M. Tewari, T. Minko and D. E. Discher, Shape effects of filaments versus spherical particles in flow and drug delivery, Nature Nanotechnology, 2, (2007), 249-255.

DOI: 10.1038/nnano.2007.70

[18] C. Chouly, D. Pouliquen, I. Lucet, J. J. Jeune and P. Jallet, Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution, Journal of Microencapsulation, 13, (1996), 245-255.

DOI: 10.3109/02652049609026013

[19] S. P. Gubin, (Ed. ), Magnetic nanoparticles, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, (2009).

[20] V. V. Mody, A. Cox, S. Shah, A. Singh, W. Bevins and H. Parihar, Magnetic nanoparticle drug delivery systems for targeting tumor, Applied Nanoscience, 4, (2014), 385-392.

DOI: 10.1007/s13204-013-0216-y

[21] S. Bucak, B. Yavuzturk and A. D. Sezer, Magnetic nanoparticles: synthesis, surface modifications and application in drug delivery, Recent Advances in Novel Drug Carrier Systems, (2012).

DOI: 10.5772/52115

[22] S. Laurent, D. Forge, M. Port, A. Roch, C. Robic, L. V. Elst and R. N. Muller, Magnetic iron nanoparticles: synthesis, stabilization, vectorization, physiochemical characterizations and biological applications, Chemical Reviews, 108, (2008).

DOI: 10.1021/cr068445e

[23] O. Veiseh, J. W. Gunn and M. Zhang, Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging, Advanced Drug Delivery Reviews, 62(3), (2010), 284-304.

DOI: 10.1016/j.addr.2009.11.002

[24] M. Mahmoudi, A. Simohi, M. Imani and M. A. Shokrgozer, A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles, Colloids and Surfaces B: Biointerfaces, 75, (2010), 300-309.

DOI: 10.1016/j.colsurfb.2009.08.044

[25] S. Bamrungsap, Z. Zhao, T. Chen, L. Wang, C. Li, T. Fu and W. Tan, Nanotechnology in therapeutics: a focus on nanoparticles as a drug delivery system, Nanomedicine, 7(8), (2012), 123-1271.

DOI: 10.2217/nnm.12.87

[26] T. Neuberger, B. Schopf, H. Hofmann, M. Hofmann and B. von Rechenberg, Superpara-magnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system, Journal of Magnetism and Magnetic Materials, 293, (2005).

DOI: 10.1016/j.jmmm.2005.01.064

[27] A. S. Lubbe, C. Bergemann, J. Brock and D. G. McClure, Physiological aspects in magnetic drug-targeting, Journal of Magnetism and Magnetic Materials, 194, (1999), 149-155.

DOI: 10.1016/s0304-8853(98)00574-5

[28] Q. A. Pankhurst, J. Cannolly, S. K. Jones and J. Dobson, Applications of magnetic nanoparticles in biomedicine, Journal of Physics D: Applied Physics, 36, (2003), R167-181.

DOI: 10.1088/0022-3727/36/13/201

[29] A. Jordan, R. Scholz, P. Wust, H. Fahling, J. Krause, W. Wlodarczyk, B. Sander, T. Vogl and R. Felix, Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo, International Journal Hyperthermia, 13, (1997), 587-605.

DOI: 10.3109/02656739709023559

[30] A. Jordan, R. Scholz, P. Wust, H. Fahling and R. Felix, Magnetic fluid Hyperthermia (MFH): cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles, Journal of Magnetism and Magnetic Materials, 201, (1999).

DOI: 10.1016/s0304-8853(99)00088-8

[31] J. L. Arias, M. Lopez-Viota, A. V. Delgado and M. A. Rceiz, Iron/ethylcellulose (core/ shell) nanoplatform loaded with 5-flurouracil for cancer targeting, Colloids and Surfaces B: Biointerfaces, 77, (2010), 111-116.

DOI: 10.1016/j.colsurfb.2010.01.030

[32] A. K. Bajpai, and R. Gupta, Magnetically mediated release of ciprofloracin from polyvinyl alcohol based superparamagnetic nanocomposites, Journals of Materials Science: Materials in Medicine, 22, (2011), 357-369.

DOI: 10.1007/s10856-010-4214-2

[33] M. Y. Hua, H. L. Liu, H. W. Yang, P. Y. Chen, R. Y. Tsai, C. Y. Huang, I. C. Tseng, L. A. Lyu, C. C. Ma, H. J. Tang, T. C. Yen and K. C. Wei, 'The effectiveness of a magnetic nanoparticle based system for BCNU in the treatment of gliomas, Biomaterials, 32, (2011).

DOI: 10.1016/j.biomaterials.2010.09.065

[34] C. Jingting, L. Huining and Z. Yi, Preparation and characterization of magnetic nanoparticles containing Fe3O4-dextran-anti-β-human chronic gonadotropin, a new generation choriocarcinoma specific gene vector, International journal of Nanomedicine, 6, (2011).

DOI: 10.2147/ijn.s13410

[35] H. Kempe and M. Kempe, The use of magnetic nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy, Biomaterials, 31, (2010), 9499-9510.

DOI: 10.1016/j.biomaterials.2010.07.107

[36] D. Losic, Y. Yu, M. S. Aw, S. Simovic, B. Thierry and J. Addai-Mensah, Surface functionalization of diatoms with dopamine modified iron-oxide nanoparticles toward magnetically guided drug microcarriers with biologically derived morphologies, Chemical Communications, 46, (2010).

DOI: 10.1039/c0cc01305f

[37] W. Wu, B. Chen, J. Cheng, J. Wang, W. Xu, L. Liu, G. Xia, H. Wei, X. Wang, M. Yang, L. Yang, Y. Zhang, C. Xu and J. Li, Biocompatibility of Fe3O4/ DNR magnetic nanoparticles in the treatment of hematologic malignancies, International Journal of Nanomedicine, 5, (2010).

DOI: 10.2147/ijn.s15660

[38] J. Yang, S. B. Park, H. G. Yoon, Y. H. Huh and S. Ham, Preparation of poly epsilon-caprolactone nanoparticles containing magnetite for magnetic drug carrier, International Journal of Pharmaceutics, 324(2), (2006), 185-190.

DOI: 10.1016/j.ijpharm.2006.06.029

[39] T. K. Jain, M. M. Torres, S. K. Sahoo, D. L. Pelecky and V. Labhasetwar, Iron oxide nanoparticles for sustained delivery of anticancer agents, Molecular Pharmaceutics, 2(3), (2005), 194-205.

DOI: 10.1021/mp0500014

[40] B. Chertok. A. E. David and V. C. Yang, Polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administration, Biomaterials, 31(24), (2010), 6317-6324.

DOI: 10.1016/j.biomaterials.2010.04.043

[41] C. Alexiou, R. Jurgons, C. Seliger, O. Brunke, H. Iro and S. Odenbach, Delivery of superparamagnetic nanoparticles for local chemotherapy after intraarterial infusion and magnetic drug targeting, Anticancer Research, 27, (2007), 2019-(2022).

[42] M. J. Maheed, Q. Lu, W. Yan, Z. Li, J. Hussain, Highly water-soluble magnetic iron oxide (Fe3O4) nanoparticles for drug delivery: enhanced in vitro therapeutic efficacy of doxorubicin and MION conjugates, Journal of Materials Chemistry B, 1(22), (2013).

DOI: 10.1039/c3tb20322k

[43] N. Schleich, P. Sibret, P. Danhier, B. Ucakar, S. Laurent, R. N. Muller, C. Jerome, B. Gallez, V. Preat and F. Danhier, Dual anticancer drug/ superparamagnetic iron oxide-loaded PLGA-based nanoparticles for cancer therapy and magnetic resonance imaging, International Journal of Pharmaceutics, 447, (2013).

DOI: 10.1016/j.ijpharm.2013.02.042

[44] S. Kayal and R. V. Ramanujam, Anti-cancer drug loaded iron-gold core-shell nanoparticles (Fe@Au) for magnetic drug targeting, Journal of Nanoscience and Nanotechnology, 10, (2010), 1-13.

DOI: 10.1166/jnn.2010.2461

[45] Y. Liu, S. Shah and J. Tan, Computational modeling of nanoparticle targeted drug delivery, Reviews in Nanoscience and Nanotechnology, 1, (2012), 66-83.

DOI: 10.1166/rnn.2012.1014

[46] J. Tan, S. Wang, J. Yang and Y. Liu, Coupled particulate and continuum model for nanoparticle targeted delivery, Computers and Structures, 122, (2013), 128-134.

DOI: 10.1016/j.compstruc.2012.12.019

[47] T. J. Chung, Computational fluid dynamics, Cambridge University Press, (2002).

[48] X. Cao, X. Han and L. Li, Numerical analysis of magnetic nanoparticle transport in microfluidic systems under the influence of permanent magnets, Journal of Physics D: Applied Physics, 45, (2012).

DOI: 10.1088/0022-3727/45/46/465001

[49] M. Babincova and P. Babinec, Magnetic drug delivery and targeting: principles and applications, Biomed Pap Med fac Univ Palacky Olomouc Czech republic, 153(4), (2009), 243-250.

DOI: 10.5507/bp.2009.042

[50] J. M. S. L. Paulo Costa, Modeling and comparison of dissolution profiles, European Journal of Pharmaceutical Sciences, 13(2), (2001), 123-133.

[51] T. Hoare, B. P. Timko, J. Santamaria, G. F. Goya, S. Lau, C. F. Stefanescu, D. Lin, R. Langer and D. S. Kohane, Magnetically-triggered nanocomposite membranes: a versatile platform for triggered drug release, Nano Letters, 11(3), (2011).

DOI: 10.1021/nl200494t

[52] R. Guenin, P. C. Clapp, Y. Zhao and J. A. Rifkin, Transformation of toughening in nial observed via monte-carlo simulations, Materials Science and Engineering B: Solid-state Materials for Advanced Technology, 37, (1996), 193-196.

DOI: 10.1016/0921-5107(95)01485-3

[53] T. Puzyn, J. Leszczynski and M. T. Cronin (Eds. ), Recent Advances in QSAR Studies: Methods and Applications, (2009).

[54] T. Puzyn, D. Leszczynska and J. Leszczynski, Toward the development of nano-QSARs,: advances and challenges, Small, 5(2), (2009), 2494-2509.

DOI: 10.1002/smll.200900179

[55] S. Wang, Y. Zhou, J. Tan, J. Xu, J. Yang and Y. Liu, Computational modeling of magnetic nanoparticle targeting to stent surface under high gradient field, Computational Mechanics, 53, (2014), 493-412.

DOI: 10.1007/s00466-013-0968-y

[56] S. Kayal, D. Bandyopadhyay, T. K. Mandal and R. V. Ramanujam, The flow of magnetic nanoparticles in magnetic drug targeting, RSC Advances, 1, (2011), 238-246.

DOI: 10.1039/c1ra00023c

[57] L. Han-dan, X. Wei, W. Shi-gang, K. Zun-ji, Hydrodynamic modeling of ferrofluid flow in magnetic targeting drug delivery, Applied Mathematics and Mechanics (English Edition), 29(10), (2008), 1341-1349.

DOI: 10.1007/s10483-008-1009-y

[58] A. Nacev, C. Beni, O. Rbuno and B. Shapiro, Magnetic nanoparticle transport within flowing blood and into surrounding tissue, Nanomedicine, 5(9), (2010), 1459-1466.

DOI: 10.2217/nnm.10.104

[59] S. Shah, Y. Liu, W. Hu and J. Gao, Modeling particle shape-dependent dynamics in nanomedicine, Journal of Nanoscience and Nanotechnology, 11(2), (2011), 919-928.

DOI: 10.1166/jnn.2011.3536

[60] M. Mahmoudi, M. A. Shokrgozer, A. Simchi, M. Imami, A. S. Milani, P. Stroeve, H. Vali, V. O. Hafeli and S. Bonakdar, Multiphysics flow modeling and in vitro toxicity of iron oxide nanoparticles coated with poly(vinyl alcohol), Journal of Physical Chemistry C, 113, (2009).

DOI: 10.1021/jp904884y