Preparation and Characterization of Coenzyme Q10-Loaded Nanostructured Lipid Carriers

Qiang Xia; Jia Ying Wu

doi:10.4028/www.scientific.net/MSF.694.170

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HomeMaterials Science ForumMaterials Science Forum Vol. 694Preparation and Characterization of Coenzyme...

Preparation and Characterization of Coenzyme Q₁₀-Loaded Nanostructured Lipid Carriers

Abstract:

The enhancement of stability of light sensitive CoQ10 was achieved by preparation of coenzyme Q10-loaded Nanostructured Lipid Carriers through High Pressure Homogenization (HPH). Well-dissolved lipids of CoQ10 were selected, optimized ratio of emusifiers and lipids were determined for the formulation. Obtained by photon correlation spectroscopy (PCS), the mean particle size of CoQ10-NLC was 112 ± 7 nm within 60 days after preparation. In terms of centrifugal stability, results of laser diffraction (LD) analysis eliminated the existence of aggregated particles with micrometers and showed almost no size growth before and after centrifugation. Zeta potential values were from -50 to -55 mV with pH in the range of 6.56–6.72. The concentration of CoQ10-NLC measured by UV-Vis spectroscopy was as high as 8.13 mg/mL.

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Periodical:

Materials Science Forum (Volume 694)

Pages:

170-174

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.694.170

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Online since:

July 2011

Authors:

Qiang Xia, Jia Ying Wu

Keywords:

Coenzyme Q₁₀, High-Pressure Homogenization, Nanostructured Lipid Carriers

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