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The Effect of Processing Parameters on Characteristics of Poly-L-Lactide Microspheres

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Abstract:

Biodegradable micro- and nanospheres made of poly-l-lactide (PLLA) are very potent drug or antigen delivery systems with inherent potential for drug and antigen targeting. The objective of this study is to formulate modified PLLA microparticles with defined size and shape that can efficiently bind bioactive component. The effects of some process variables on the size distribution of particles prepared by precipitation method are examined. The main focus is to study the effect of co-solvent selection and poly(vinyl alcohol) PVA concentration on the shape and size of the particles. Chlorophorm is used as a solvent. Methanol (MeOH) and ethanol (EtOH) are selected as co-solvents. Motivation for replacing MeOH with EtOH in pharmaceutical applications is explained by less harmful nature of EtOH. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) are used to characterize the particles. Optimal particles are achieved in ethanol and at higher PVA concentration

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Info:

Periodical:

Materials Science Forum (Volume 555)

Pages:

453-458

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.555.453

Citation:

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Online since:

September 2007

Authors:

Ivana Jovanović, Magdalena Stevanović, B. Nedeljković, N. Ignjatović

Keywords:

Drug Delivery, Micro-Sphere, PLLA, Precipitation

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References

[1] U. Edlund and A. -C. Albertsson: Advances in Polymer Science Vol. 157 (2002), p.67.

Google Scholar

[2] S. Freitas, H.P. Merkle and B. Gander: Journal of Controlled Release Vol. 102 (2005), p.313.

Google Scholar

[3] D. Radulescu: US Patent No. 6, 998, 074 B1, Feb. 14, (2006).

Google Scholar

[4] M.L. Hans: Synthesis, characterization, and application of biodegradable polymeric prodrug micelles for long-term drug delivery (PhD thesis, Drexel University 2005).

DOI: 10.17918/etd-879

Google Scholar

[5] P. Chattopadhyay, B.Y. Shekunov, J.S. Seitzenger and R.W. Huff: US Patent No. 6, 966, 990 B2, November 22, (2005).

Google Scholar

[6] R. Dinarvand, S.H. Moghadam, L. Mohammadyari-Fard and F. Atyabi: AAPS PharmSciTech Vol. 4 (3) (2003), Article 34.

DOI: 10.1208/pt040334

Google Scholar

[7] R.T. Liggins and H.M. Burt: International Journal of Pharmaceutics Vol. 222 (2001), p.19.

Google Scholar

[8] R.T. Liggins and H.M. Burt: International Journal of Pharmaceutics Vol. 281 (2004), p.103.

Google Scholar

[9] T. -W. Chung, Y. -Y. Huang and Y. -Z. Liu: International Journal of Pharmaceutics Vol. 212 (2001), p.161.

Google Scholar

[10] H. Murakami, M. Kobayashi, H. Takeuchi and Y. Kawashima: Powder Technology Vol. 107 (2000), p.137.

Google Scholar

[11] L. Peltonen, P. Koistinen, M. Karjalainen, A. Häkkinen and J. Hirvonen: AAPS PharmSciTech Vol. 3(4) (2002), Article 32.

DOI: 10.1208/pt030432

Google Scholar

[12] S. Hyvönen, L. Peltonen, M. Karjalainen and J. Hirvonen: International Journal of Pharmaceutics Vol. 295 (2005), p.269.

Google Scholar

[13] S. Hirsjärvi, L. Peltonen and J. Hirvonen: Colloids and Surfaces B: Biointerfaces Vol. 49 (2006), p.93.

Google Scholar

[14] M. Stevanović, N. Ignjatović, B. Jordović and D. Uskoković: Journal of Material Sciences: Materials in Medicine, (2006 accepted).

Google Scholar

[15] Y. Mizutania, M. Hattoria, M. Okuyamaa, T. Kasugab and M. Nogamib: Polymer Vol. 46 (2005), p.3789.

Google Scholar

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