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HomeKey Engineering MaterialsKey Engineering Materials Vol. 757Physico-Chemical and In Vitro Cytotoxic Properties...

Physico-Chemical and In Vitro Cytotoxic Properties of Alginate/Soy Protein Isolated Scaffolds for Tissue Engineering

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Abstract:

Three-dimensional (3D) porous alginate/soy protein isolated (Alg/SPI) tissue engineering scaffolds were achieved by freeze-drying. The physico-chemical attributes of the scaffolds including morphology, chemical structure, mechanical properties and in vitro cytotoxicity were investigated for different SPI blends. Results indicated that increasing SPI content to 40 wt% in the blends resulted in the partial existence of closed pores and reduced pore size. The mechanical values of the scaffolds under compression also reduced with increasing SPI in the blends. The addition of SPI did not significantly enhance the cell viability of the scaffolds investigated for in vitro culture with human fibroblasts, which remained in the high (90 – 100%) range. Results demonstrated that Alg/SPI scaffolds have potential for use as tissue engineering scaffolds.

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Periodical:

Key Engineering Materials (Volume 757)

Pages:

46-51

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.757.46

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Online since:

October 2017

Authors:

Patcharakamon Nooeaid*, Piyachat Chuysinuan, Supanna Techasakul, Kriengsak Lirdprapamongkol, Jisnuson Svasti

Keywords:

Alginate, Freeze-Drying, Scaffolds, Soy Protein Isolated, Tissue Engineering

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* - Corresponding Author

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