Biocompatible Tough Hydrogels via Micellar Copolymerization of NIPAM and Stearyl Acrylate: Synthesis and Characterization

Xi De Xu; Jie Liu; You Ping Wu; Jian Ping Deng

doi:10.4028/www.scientific.net/KEM.748.96

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 748Biocompatible Tough Hydrogels via Micellar...

Biocompatible Tough Hydrogels via Micellar Copolymerization of NIPAM and Stearyl Acrylate: Synthesis and Characterization

Abstract:

Novel biocompatible tough hydrogels were prepared through free radical micellar polymerization of N-isopropylacrylamide (NIPAM) with ammonium persulphate (APS) as initiator, in which hydrophobic monomer stearyl acrylate (C18) underwent micellar polymerization in the presence of gelatin as emulsifier. FT-IR and DSC demonstrated the formation of co-polymer of NIPAM and C18. Swelling results indicated that hydrophobic polymer domains derived from C18 in aqueous medium acted as the physical crosslinking points by hydrophobic association. Uniaxial tensile test demonstrated the mechanical properties of hydrogels increased with increasing C18 and gelatin contents. The hydrogel exhibited low toxicity and promoted cell proliferation. The desirable toughness, low toxicity and the promoting effect of cell proliferation made the present hydrogels good candidates for tissue regeneration materials.

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Advanced Materials and Engineering Materials VI

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Periodical:

Key Engineering Materials (Volume 748)

Pages:

96-102

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.748.96

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Online since:

August 2017

Authors:

Xi De Xu, Jie Liu, You Ping Wu*, Jian Ping Deng

Keywords:

Cytotoxicity, Hydrogel, Hydrophobic Association, Mechanical Properties

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