Paper Titles

Synthesis and Characterization of CoFe₂O₄ & NiFe₂O₄ Magnetic Nanoparticles for Various Biomedical Applications: Cell Viability and Cell Death Evaluations
p.1

Effects of Ni Concentration on the Structural and Magnetic Properties of NiZnFe₂O₄ Ferrites Synthesized via a Polymer Precursor
p.9

Sensitivity Parameter Analysis of Graphene Based Bimetallic Surface Plasmon Resonance Biosensor
p.17

Effect of Annealing on Optical and Structural Properties of Rutile TiO₂ Nanoarrays
p.23

Nanocarriers for Delivery of Herbal Based Drugs in Breast Cancer - An Overview
p.29

Dispersion, Characterization and Uptake of Multi-Walled Carbon Nanotubes by Epithelial Cells
p.41

Detecting Antibody-Labeled BCG MNPs Using a Magnetoresistive Biosensor and Magnetic Labeling Technique
p.49

Comparative Study of AFM and FESEM for Imaging the Single Cell of Escherichia Coli Bacteria
p.61

Ferroelectric-Relaxor Behavior of Highly Epitaxial Barium Zirconium Titanate Thin Films
p.67

HomeJournal of Nano ResearchJournal of Nano Research Vol. 34Nanocarriers for Delivery of Herbal Based Drugs in...

Nanocarriers for Delivery of Herbal Based Drugs in Breast Cancer - An Overview

Article Preview

Abstract:

Breast cancer is the second leading cause of cancer death in women all over the world. Despite advanced treatment modalities, the systemic toxicity remains a major side effect resulting into patient morbidity and mortality. Recently, natural products are being targeted for drug discovery because of their major role in cancer prevention and treatment. Plants have been the main source of natural compounds that are being used in medicine. However, most of the herbal bioactives are hydrophobic in nature resulting into their limited bioavailability and in turn their therapeutic efficacy. To overcome this problem, different nanocarriers such as nanoparticles, nanocapsules, liposomes, quantum dots, phytosomes, dendrimers and nanoemulsions have been conjugated with anticancer herbal bioactives. Such nanochemotherapeutic agents exhibit increased bioavaibility, enhanced pharmacological activity and stability with reduced systemic toxicity. While majority of the reviews focus upon herbal loaded nanoformulations for various biological applications, this report is an attempt to particularly highlight the potential of nanotechnology in the delivery of herbal bioactives for breast cancer management.

You might also be interested in these eBooks

Journal of Nano Research Vol. 34

Info:

Periodical:

Journal of Nano Research (Volume 34)

Pages:

29-40

DOI:

https://doi.org/10.4028/www.scientific.net/JNanoR.34.29

Citation:

Cite this paper

Online since:

July 2015

Authors:

Kirtee Wani, Kirtan Tarawadi, Ruchika Kaul-Ghanekar*

Keywords:

Breast Cancer, Drug Delivery, Herbal Drugs, Nanocarriers, Nanotechnology

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

* - Corresponding Author

[1] D. Carter, New global survey shows an increasing cancer burden, Am. J. Nurs. 114(3) (2014) 17.

[2] R. Siegel, J. Ma, Z. Zou, A. Jemal, Cancer statistics, 2014, CA Cancer J. Clin., 64(1) (2014) 9-29.

DOI: 10.3322/caac.21208

[3] N. Murthy, U. Agarwal, K. Chaudhry, S. Saxena, A study on time trends in incidence of breast cancer –Indian scenario, Eur. J. Cancer Care, 16 (2007) 185-186.

DOI: 10.1111/j.1365-2354.2006.00761.x

[4] A. Khokhar, Breast Cancer in India: Where do we stand and where do we go?, Asian Pacific J Cancer Prev, 13(10) (2012) 4861-4866.

DOI: 10.7314/apjcp.2012.13.10.4861

[5] H. Boon, M. Stewart, M. A. Kennard, R. Gray, C. Sawka, J. B. Brown, C. McWilliam, A. Gavin, R. A. Baron, D. Aaron, T. Haines-Kamka, Use of complementary/alternative medicine by breast cancer survivors in Ontario: prevalence and perceptions, J. Clin. Oncol., 18(13) (2000).

DOI: 10.1200/jco.2000.18.13.2515

[6] M. Zhang, X. Liu, J. Li, L. He, D. Tripathy, Chinese medicinal herbs to treat the side-effects of chemotherapy in breast cancer patients, Cochrane Database Syst. Rev. (2) (2007) CD004921.

DOI: 10.1002/14651858.cd004921.pub2

[7] G. S. Liao, M. K. Apaya, L. F. Shyur, Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy, Evid Based Complement Alternat Med. 2013 (2013) 437948.

DOI: 10.1155/2013/437948

[8] C. M. Kaefer, J. A. Milner, Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Chapter 17 Herbs and Spices in Cancer Prevention and Treatment.

DOI: 10.1201/b10787-18

[9] S. J. Koppikar, A. S. Choudhari, S. A. Suryavanshi, S. Kumari, S. Chattopadhyay, R. Kaul-Ghanekar, Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential, BMC Cancer, 10 (2010).

DOI: 10.1186/1471-2407-10-210

[10] A. S. Choudhari, S. A. Snehal, R. Kaul-Ghanekar, The aqueous extract of Ficus religiosa induces cell cycle arrest in human cervical cancer cell lines SiHa (HPV-16 Positive) and apoptosis in HeLa (HPV-18 Positive), Plos One, (2013).

DOI: 10.1371/journal.pone.0070127

[11] S. Suryavanshi, A. Choudhari, R. Deshpande, O. Kulkarni, R. Kaul- Ghanekar, Analyzing the antioxidant potential of aqueous and ethanolic preparations of a herbal composition (HC9) and evaluating their cytotoxic activity in breast cancer cell lines, Biotechnol. Bioinf. Bioeng., 1(4) (2011).

[12] W. Tan, J. Lu, M. Huang, Y. Li, M. Chen, G. Wu, J. Gong, Z. Zhong, Z. Xu, Y. Dang, J. Guo, X. Chen, Y. Wang. Anti-cancer natural products isolated from Chinese medicinal herbs. Chin Med., 6(1) (2011) 27.

DOI: 10.1186/1749-8546-6-27

[13] V. A. Bhattaram, U. Graefe, C. Kohlert, M. Veit, H. Derendorf, Pharmacokinetics and bioavailability of herbal medicinal products, Phytomedicine, 9 Suppl 3: (2002) 1-33.

DOI: 10.1078/1433-187x-00210

[14] E. A. Abourashed, Bioavailability of plant-derived antioxidants, Antioxidants, 2 (2013) 309-325.

DOI: 10.3390/antiox2040309

[15] C. Jantarat, Bioavailability enhancement techniques of herbal medicine: a case example of curcumin, Int. J. Pharm. Pharm. Sci., 5(1) (2013) 493-500.

[16] K. Kesarwani, R. Gupta, A. Mukerjee, Bioavailability enhancers of herbal origin: An overview, Asian Pac. J. Trop. Biomed., 3(4) (2013) 253-66.

[17] S. S. Bhadoriya, A. Mangal, N. Madoriya, P. Dixit, Bioavailability and bioactivity enhancement of herbal drugs by Nanotechnology,: a review, JCPR, 8(1) (2011) 1-7.

[18] Muqbil, A. Masood, F. H. Sarkar, R. M. Mohammad, A. S. Azmi, Progress in nanotechnology based approaches to enhance the potential of chemopreventive agents, Cancers (Basel), 3(1) (2011) 428-45.

DOI: 10.3390/cancers3010428

[19] S. Medhe, P. Bansal, S. K. Roy, M. G. R. Rajan, M. M. Srivastava, Combination and nanotech enhancement in anti-breast cancer efficacy: dietary chemopreventing agent, BioNanoSci. 3 (2013) 295–301.

DOI: 10.1007/s12668-013-0093-6

[20] B. V. Bonifácio, P. B. Silva, M. A. Ramos, K. M. Negri, T. M., Bauab, M. Chorilli, Nanotechnology-based drug delivery systems and herbal medicines: a review, Int. J. Nanomedicine., 9 (2014) 1-15.

DOI: 10.2147/ijn.s52634

[21] R. K. Thapa, G. M. Khan, K. Parajuli-Baral, P. Thapa, Herbal medicine incorporated nanoparticles: advancements in herbal treatment, Asian Journal of Biomedical and Pharmaceutical Sciences, 3(24) (2013) 7-14.

[22] M. Mathur, G. Vyas, Role of nanoparticles for production of smart herbal drug-an overview, Indian J. Nat. Prod. Resour. 4(4) (2013) 329-338.

[23] M. V. Yezhelyev, X. Gao, Y. Xing, A. Al-Hajj, S. Nie, R. M. O'Regan, Emerging use of nanoparticles in diagnosis and treatment of breast cancer, Lancet Oncol., 7(8) (2006) 657-667.

DOI: 10.1016/s1470-2045(06)70793-8

[24] S. R. Grobmyer, D. L. Morse, B. Fletcher, L. G. Gutwein, P. Sharma, V. Krishna, S. C. Frost, B. M. Moudgil, S. C. Brown, The promise of nanotechnology for solving clinical problems in breast cancer, J. Surg. Oncol., 103(4) (2011) 317-25.

DOI: 10.1002/jso.21698

[25] R. Chang, Bioactive polysaccharides from traditional Chinese medicine herbs as anticancer adjuvants, The Journal of Alternative and Complementary Medicine, 8(5) (2002) 559-565.

DOI: 10.1089/107555302320825066

[26] Abirami, S. M. Halith, K. K. Pillai, C. Anbalagan, Herbal nanoparticle for anticancer potential- a review, World Journal of Pharmacy and Pharmaceutical Sciences, 3(8) (2014) 2123-2132.

[27] S. Dev, P. Prabhakaran, L. Filgueira, K. S. Iyer, C. L. Raston, Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent, Nanoscale, 4 (2012) 2575-2579.

DOI: 10.1039/c2nr11502f

[28] D. Zucker, Y. Barenholz, Optimization of vincristine-topotecan combination-paving the way for improved chemotherapy regimens by nanoliposomes, J. Control Release, 146 (2010) 326-333.

DOI: 10.1016/j.jconrel.2010.05.024

[29] Abe, N. Abgrall, H. Aihara, Y. Ajima, J. B. Albert, et al, The T2K experiment. Nuclear Instruments & Methods in Physics Research Section a-Accelerators Spectrometers Detectors and Associated Equipment, 659 (2011) 106-135.

DOI: 10.1016/j.nima.2010.02.164

[30] F. Odeh, S. I. Ismail, R. Abu-Dahab, I. S. Mahmoud, A. Al Bawab, Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer, Drug Deliv., 19(8) (2012) 371-7.

DOI: 10.3109/10717544.2012.727500

[31] N. Kontogiannopoulos, A. N. Assimopoulou, S. Hatziantoniou, K. Karatasos, C. Demetzos, V. P. Papageorgiou, Chimeric advanced drug delivery nano systems (chi-aDDnSs) for shikonin combining dendritic and liposomal technology, Int. J. Pharm., 422(1-2) (2012).

DOI: 10.1016/j.ijpharm.2011.09.031

[32] X. Ma, J. Zhou, C. X. Zhang, X. Y. Li, N. Li, R. J. Ju, J. F. Shi, M. G. Sun, W. Y. Zhao, L. M. Mu, Y. Yan, W. L. Lu, Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes, Biomaterials, 34(18) (2013).

DOI: 10.1016/j.biomaterials.2013.02.066

[33] N. Dadgar, S. E. Alavi, M. K. Esfahani, A. Akbarzadeh, Study of toxicity effect of pegylated nanoliposomal artemisinin on breast cancer cell line, Indian J. Clin. Biochem., 28(4) (2013) 410-2.

DOI: 10.1007/s12291-013-0306-3

[34] Mei, Y. Zhang, Y. Zheng, G. Tian, C. Song, D. Yang, H. Chen, H. Sun, Y. Tian, K. Liu, Z. Li, L. Huang, A novel docetaxel-loaded poly (ε-caprolactone)/pluronic F68 nanoparticle overcoming multidrug resistance for breast cancer treatment, Nanoscale Res. Lett., 4(12) (2009).

DOI: 10.1007/s11671-009-9431-6

[35] V. Bhardwaj, D. D. Ankola, S. C. Gupta, M. Schneider, C. M. Lehr, M. N. V . Ravi Kumar, PLGA nanoparticles stabilized with cationic surfactant: safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat, Pharmaceutical Research, 26(11) (2009).

DOI: 10.1007/s11095-009-9965-4

[36] K. H. Min, K. Park, Y. S. Kim, S. M. Bae, S. Lee, H. G. Jo, R. W. Park, I. S. Kim, S. Y. Jeong, K. Kim, I. C. Kwon, Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. J Control Release, 127(3) (2008).

DOI: 10.1016/j.jconrel.2008.01.013

[37] V. Saxena, M. D. Hussain, Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer, Int. J. Nanomedicine., 7 (2012) 713–721.

DOI: 10.2147/ijn.s28745

[38] Wang, S. Wang, R. Chen, Y. Wang, H. Li, Y. Wang, M. Chen, Oridonin Loaded Solid Lipid Nanoparticles Enhanced Antitumor Activity in MCF-7 Cells, Journal of Nanomaterials, 2014 (2014) Article ID 903646.

DOI: 10.1155/2014/903646

[39] Y. P. Fang, Y. K. Lin, Y. H. Su, J. Y. Fang, Tryptanthrin-loaded nanoparticles for delivery into cultured human breast cancer cells, MCF7: the effects of solid lipid/liquid lipid ratios in the inner core, Chem. Pharm. Bull., 59(2) (2011) 266-271.

DOI: 10.1248/cpb.59.266

[40] Khoobchandani, A. Zambre, K. Katti, C. H. Lin, V. K. Kattesh, Green Nanotechnology from Brassicaceae: Development of Broccoli Phytochemicals–Encapsulated Gold Nanoparticles and Their Applications in Nanomedicine, International Journal of Green Nanotechnology, 1 (2013).

DOI: 10.1177/1943089213509474

[41] U. K. Parida, B. K. Bindhani, P. Nayak, Green Synthesis and Characterization of Gold Nanoparticles Using Onion (Allium cepa) Extract, World Journal of Nano Science and Engineering, 1 (2011) 93-98.

DOI: 10.4236/wjnse.2011.14015

[42] F. Dilnawaz, A. Singh, C. Mohanty, S. K. Sahoo, Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy, Biomaterials, 31(13) (2010) 3694-706.

DOI: 10.1016/j.biomaterials.2010.01.057

[43] D. Dorniani, M. Z. Bin Hussein, A. U. Kura, S. Fakurazi, A. H. Shaari, Z. Ahmad, Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery, Dovepress, 2012(7) (2012) 5745-5756.

DOI: 10.2147/ijn.s35746

[44] Z. Ebrahimnezhad, N. Zarghami, M. Keyhani, S. Amirsaadat, A. Akbarzadeh, M. Rahmati, M. Z. Taheri, K. Nejati-Koshki, Inhibition of hTERT Gene Expression by Silibinin-Loaded PLGA-PEG-Fe3O4 in T47D Breast Cancer Cell Line, Bioimpacts, 3(2) (2013).

DOI: 10.15171/bi.2018.34

[45] S. Sebak, M. Mirzaei, M. Malhotra, A. Kulamarva, S. Prakash, Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis, Int. J. Nanomedicine, 5 (2010).

DOI: 10.2147/ijn.s10443

[46] K. D. Wani, R. Kitture, A. Ahmed, A. S. Choudhari, S. J. Koppikar, R Kaul-Ghanekar, Synthesis, characterization and in vitro study of Curcumin-functionalized Citric acid-Capped Magnetic (CCF) Nanoparticles as drug delivery agents in cancer. Journal of Bionanoscience 5 (2011).

DOI: 10.1166/jbns.2011.1041

[47] K. D. Wani, B. S. Kadu, P. Gupta, A. V. Deore, R. Chikate, P. Poddar, S. Dhole, R. Kaul-Ghanekar, Synthesis, characterization and in vitro study of biocompatible Cinnamaldehyde functionalized magnetite nanoparticles (CPGF NPs) for hyperthermia and drug delivery applications in breast cancer. PLoS ONE 9(9) (2014).

DOI: 10.1371/journal.pone.0107315

[48] W. D. Foulkes, Triple-negative breast cancer, N. Engl. J. Med., 363 (2010) 1938-(1948).

[49] Safavy, K. P. Raisch, M. B. Khazaeli, D. J. Buchsbaum, J. A. Bonner, Paclitaxel derivatives for targeted therapy of cancer: toward the development of smart taxanes, J. Med. Chem., 42(23) (1999) 4919–4924.

DOI: 10.1021/jm990355x

[50] M. Gümüş, N. Davidson, T. Bauknecht, V. Soldatenkova, K. A. Benhadji, Taxane-based mono- or combination therapy for managing metastatic breast cancer (MBC) in routine practice: a multinational prospective observational study, Curr. Med. Res. Opin., 28(3) (2012).

DOI: 10.1185/03007995.2011.651795

[51] E. Perez, American Pharmaceutical Partners announces presentation of Abraxane survival data. In: 22nd annual Miami Breast Cancer Conference; Miami, FL, (2005).

[52] K. S. Lee, Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer, Breast Cancer Res. Treat., (2007).

DOI: 10.1007/s10549-007-9591-y

[53] K. S. Albain, C. P. Belani, P Bonomi, et al. PIONEER: a phase III randomized trial of paclitaxel poliglumex versus paclitaxel in chemotherapynaive women with advanced-stage non-small-cell lung cancer and performance status of 2. Clin. Lung Cancer, 7 (2006).

DOI: 10.3816/clc.2006.n.027

[54] W. Liang, M. Lou, W. Si, Nano anticancer micelles of vinca alkaloids entrapped in polyethylene glycolated phospolipids. US Patent 20090053293 A1, 26 February (2009).

[55] S. E. Zale, G. Troiana, M. M. Ali, J. Hrkach, J. Wright, Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using them, US Patent 20100104655 A1, 29 April (2010).

[56] B. Rigas, G. Mackenzie, S. Yu, L. Huang, R. Zhu, T. Nie, Combination treatments and formulations for cancer, WO Patent 2011130486 A2, 20 October (2011).

[57] L. Einbond, S. Redenti, Growth inhibitoyr effects of nanoparticles containing triterpene glycosides or triterpenes, US Patent 2013/0177657 A1, 11 July (2013).