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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 679Biological Evaluation and Characterisation of...

Biological Evaluation and Characterisation of Novel Hydrogel Matrices as Scaffolds for Bone Tissue Engineering

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Abstract:

Novel photopolymerised composite hydrogels based on PEGDMA, maleic chitosan and maleic PVA were investigated for their suitability in bone tissue engineering applications. Initial swelling and compression studies revealed that the hydrogels permitted the retention of aqueous solution while still maintaining structural integrity. Promising cytotoxicity data was obtained during direct and indirect contact exposure of composite hydrogels to pre-osteoblast (MC3T3-E1) cells. Hybrid hydrogels displayed minimal cytotoxic properties and allow tailoring of mechanical properties by variation of the loading of the maleic component in the composite. Scanning electron microscopy and live-dead staining of composite hydrogels also revealed that maleic chitosan based gels supported the adhesion of MC3T3-E1 cells and may have potential as bone tissue engineering scaffolds.

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Periodical:

Applied Mechanics and Materials (Volume 679)

Pages:

63-75

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.679.63

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Online since:

October 2014

Authors:

Laura Grehan, John Killion, Sinead Devery, Clement Higginbotham, Luke Geever

Keywords:

Bone Tissue Engineering, Cell Adhesion, Hydrogels, PEGDMA

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