Surface Properties and Cell Response of Bioactive Thermally Grown TiO2 Nanofibers

A.W. Tan; Belinda Pingguan-Murphy; Roslina Ahmad; Sheikh Akbar

doi:10.4028/www.scientific.net/AMM.575.219

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 575Surface Properties and Cell Response of Bioactive...

Surface Properties and Cell Response of Bioactive Thermally Grown TiO₂ Nanofibers

Abstract:

Titania nanofiber (TiO₂NFs) arrays were fabricated in situ on a Ti-6Al-4V substrate by an oxidation process. Their surface morphology, crystallographic structure, surface roughness and wettability were characterized, as well as their in vitro interaction with bovine articular chondrocytes at different time points. Results showed that TiO₂ NFs possessed greater surface roughness, hydrophilicity and degree of crystallinity. The in vitro cell studies revealed that TiO₂ NFs substrate triggers enhanced cell adhesion, proliferation and extracellular matrix (ECM) formation compared to the untreated control sample. These results showed that chondrocytes have an affinity to the nanofibrous substrate surface and thus we suggest that such surfaces are suited to be used as an implant designed for cartilage growth.

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Periodical:

Applied Mechanics and Materials (Volume 575)

Pages:

219-222

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.575.219

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Online since:

June 2014

Authors:

A.W. Tan*, Belinda Pingguan-Murphy, Roslina Ahmad, Sheikh Akbar

Keywords:

Cellular Response, Nanofiber, Surface Properties, TiO₂

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* - Corresponding Author

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