Inhibition of Potassium Citrate on Aggregation of Nano Calcium Oxalate Crystal in Four Different Systems

Xiao Ling Wen; Cai Yan Tan; Jun Fa Xue; Jian Ming Ouyang

doi:10.4028/www.scientific.net/AMR.1052.273

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1052Inhibition of Potassium Citrate on Aggregation of...

Inhibition of Potassium Citrate on Aggregation of Nano Calcium Oxalate Crystal in Four Different Systems

Abstract:

The effects of potassium citrate (K₃cit) on sedimentation and aggregation of 50 nm calcium oxalate dihydrate (COD) crystals was studied in order to explore the mechanism of formation and inhibition of kidney stone. In four different systems, including pure water, urine of healthy person and CaOx stone former before and after taking medicine K₃cit, the influences of K₃cit on average size (), Zeta potential and optical density of nanoCOD suspensions were studied by nanoparticle size Zeta potential analyzer and ultraviolet spectrophotometer. It was showed that K₃cit could specifically adsorb on nanoCOD crystals, and also competed with the inhibitor molecules in urine. Due to the decrease of inhibitors in urine of patients, K₃cit can be better to fulfill its inhibitory effect, leading to the largest reduced values of the diameter of COD crystal and the optical density of urine suspension. In conclusion, the inhibitory effect of K₃cit on aggregation and sedimentation of calcium oxalate crystals is better in urine of patients, whereas the inhibitory effect has been reduced in urine of control group and patients after taking k₃cit.

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Periodical:

Advanced Materials Research (Volume 1052)

Pages:

273-278

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1052.273

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Online since:

October 2014

Authors:

Xiao Ling Wen, Cai Yan Tan, Jun Fa Xue, Jian Ming Ouyang*

Keywords:

Aggregation Inhibition, Calcium Oxalate, Nanocrystal, Potassium Citrate

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* - Corresponding Author

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