Elsevier

Clinical Lung Cancer

Volume 5, Issue 5, March 2004, Pages 290-298
Clinical Lung Cancer

Comprehensive Review
Integration of Multimodality Approaches in the Management of Malignant Pleural Mesothelioma

https://doi.org/10.3816/CLC.2004.n.008Get rights and content

Abstract

More than half a century after the first descriptions of mesothelioma as a pathologic entity, satisfactory treatment is still elusive. Although relatively uncommon, the incidence of mesothelioma will most likely increase over the next 10-20 years. Advances have been made in understanding the pathogenesis, diagnosis, and staging, but they have not translated into markedly improved survival. Some use palliative treatment as the primary means of therapy even now. On the other hand, a cadre of individuals have studied how surgery, chemotherapy, and radiation therapy affect the disease. Although each individual modality has had limited success by itself, a multimodality approach has been documented to improve survival and quality of life. In addition, intriguing discoveries in immunology and gene profiling and therapy promise hope for further improvement. In this article, we will illustrate the current views on integrating these different approaches and delineate areas of active research.

References (95)

  • VW Rusch et al.

    A phase II trial of surgical resection and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma

    J Thorac Cardiovasc Surg

    (2001)
  • S Singhal et al.

    Malignant mesothelioma: options for management

    Surg Clin North Am

    (2002)
  • P Baas

    Chemotherapy for malignant mesothelioma: from doxorubicin to vinorelbine

    Semin Oncol

    (2002)
  • P Baas et al.

    The activity of raltitrexed (Tomudex) in malignant pleural mesothelioma: an EORTC phase II study (08992)

    Eur J Cancer

    (2003)
  • R Stahel et al.

    Neoadjuvant chemotherapy followed by pleuropneumonectomy for pleural mesothelioma: A multicenter phase II trial of the SAKK

    Lung Cancer

    (2003)
  • HI Pass et al.

    Characteristics of nine newly derived mesothelioma cell lines

    Ann Thorac Surg

    (1995)
  • GB Ratto et al.

    Pleural space perfusion with cisplatin in the multimodality treatment of malignant mesothelioma: a feasibility and pharmacokinetic study

    J Thorac Cardiovasc Surg

    (1999)
  • PH Sugarbaker et al.

    Diagnosis and treatment of peritoneal mesothelioma: The Washington Cancer Institute experience

    Semin Oncol

    (2002)
  • J Carmichael et al.

    Radiation sensitivity of human lung cancer cell lines

    Eur J Cancer Clin Oncol

    (1989)
  • S Yajnik et al.

    Hemithoracic radiation after extrapleural pneumonectomy for malignant pleural mesothelioma

    Int J Radiat Oncol Biol Phys

    (2003)
  • A Ahamad et al.

    Intensity-modulated radiation therapy: a novel approach to the management of malignant pleural mesothelioma

    Int J Radiat Oncol Biol Phys

    (2003)
  • KM Forster et al.

    Intensity-modulated radiotherapy following extrapleural pneumonectomy for the treatment of malignant mesothelioma: clinical implementation

    Int J Radiat Oncol Biol Phys

    (2003)
  • VW Rusch et al.

    Important prognostic factors in patients with malignant pleural mesothelioma, managed surgically

    Ann Thorac Surg

    (1999)
  • JS Friedberg et al.

    A phase I study of Foscan-mediated photodynamic therapy and surgery in patients with mesothelioma

    Ann Thorac Surg

    (2003)
  • AK Nowak et al.

    New approaches for mesothelioma: biologics, vaccines, gene therapy, and other novel agents

    Semin Oncol

    (2002)
  • BW Robinson et al.

    Localised spontaneous regression in mesothelioma –possible immunological mechanism

    Lung Cancer

    (2001)
  • HI Pass et al.

    Emerging translational therapies for mesothelioma

    Chest

    (1999)
  • VW Rusch

    Diagnosis and treatment of pleural mesothelioma

    Semin Surg Oncol

    (1990)
  • D Whitaker et al.

    Early diagnosis of malignant mesothelioma: The contribution of effusion and fine needle aspiration cytology and ancillary techniques

  • T van Gelder et al.

    The influence of the diagnostic technique on the histopathological diagnosis in malignant mesothelioma

    Virchows Arch A Pathol Anat Histopathol

    (1991)
  • VW Rusch et al.

    The importance of surgical staging in the treatment of malignant pleural mesothelioma

    J Thorac Cardiovasc Surg

    (1996)
  • HI Pass et al.

    Preoperative tumor volume is associated with outcome in malignant pleural mesothelioma

    J Thorac Cardiovasc Surg

    (1998)
  • DJ Sugarbaker et al.

    Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients

    J Thorac Cardiovasc Surg

    (1999)
  • S Mohr et al.

    [Gene expression profiling in human mesothelioma cells using DNA microarray and high-density filter array technologies]

    Bull Cancer

    (2001)
  • E Kettunen et al.

    Gene expression profiling of malignant mesothelioma cell lines: cDNA array study

    Int J Cancer

    (2001)
  • MJ van de Vijver et al.

    A gene-expression signature as a predictor of survival in breast cancer

    N Engl J Med

    (2002)
  • GJ Gordon et al.

    Using gene expression ratios to predict outcome among patients with mesothelioma

    J Natl Cancer Inst

    (2003)
  • HI Pass et al.

    Gene expression profiles predict survival and progression of pleural mesothelioma

    Clin Cancer Res

    (2004)
  • HI Pass et al.

    Malignant pleural mesothelioma

    Curr Probl Surg

    (1993)
  • EG Butchart et al.

    Pleuropneumonectomy in the management of diffuse malignant mesothelioma of the pleura. Experience with 29 patients

    Thorax

    (1976)
  • AP Chahinian et al.

    Diffuse malignant mesothelioma. Prospective evaluation of 69 patients

    Ann Intern Med

    (1982)
  • P Ruffie et al.

    Diffuse malignant mesothelioma of the pleura in Ontario and Quebec: a retrospective study of 332 patients

    J Clin Oncol

    (1989)
  • JC Harvey et al.

    Malignant pleural mesothelioma: a survival study

    J Surg Oncol

    (1990)
  • S Geroulanos et al.

    Malignant pleural mesothelioma: diagnosis, therapy and prognosis

    Schweiz Rundsch Med Prax

    (1990)
  • KB Allen et al.

    Malignant pleural mesothelioma. Extrapleural pneumonectomy and pleurectomy

    Chest Surg Clin N Am

    (1994)
  • HI Pass et al.

    Surgically debulked malignant pleural mesothelioma: results and prognostic factors

    Ann Surg Oncol

    (1997)
  • HJ Wanebo et al.

    Pleural mesothelioma

    Cancer

    (1976)
  • Cited by (0)

    View full text