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Determination of amikacin by Rayleigh scattering method based on the covalent bonding of the analyte with a water soluble polymer

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Abstract

A method for the determination of aminoglycoside antibiotics based on the covalent bonding of the analyte with a water-soluble polymer by the Rayleigh scattering method (λex = λem) is proposed. Determination of amikacin (as a model analyte) is carried out by the carbodiimide crosslinking technique, which forms amide bonds between the copolymer of 4-styrenesulfonic acid and maleic acid and the primary amine groups of amikacin. The conditions of the reaction are selected to obtain maximum scattering intensity of the product: reaction time 15 min, pH 7.0, ionic strength 0.02, and measuring of scattering intensity at 362 nm. The determination of amikacin is not influenced by the following (mol/mol ratios): Al(III), Co(II), Cu(II), Fe(III), Ni(II), Zn(II)—300; Cl– and NO3 -—250; Ca(II) and Mg(II)—50; HCO3 -—20; it is affected by nitrogen compounds at 20–50-fold ratios and proteins at a 2.5-fold ratio. The calibration plot is constructed over the range of 0.2–35 mg/L (r = 0.993); LOD (3s-criterium) is 0.08 mg/L (n = 10, P = 0.95). Analyses are performed on drug powder for injection and gel.

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References

  1. Pasternack, R.F. and Collings, P.J., Science, 1995, vol. 269, p.935.

    Article  CAS  Google Scholar 

  2. Yguerabide, J. and Yguerabide, E.E., J. Cellur. Biochem., 2001, vol. 37, p.71.

    Article  Google Scholar 

  3. Satpute, S.K., Banpurkar, A.G., Dhakephalkar, P.K., Banat, I.M., and Chopade, B.A., Crit. Rev. Biotechnol., 2010, vol. 30, p.127.

    Article  CAS  Google Scholar 

  4. Lu, W., Band, B.S.F., Yu, Y., Li, Q.G., Shang, J.C., et al., Microchim. Acta, 2007, vol. 158, p.29.

    Article  CAS  Google Scholar 

  5. Shakil, S., Khan, R., Zarrilli, R., and Khan, A.U., J. Biomed. Sci., 2008, vol. 15, p.5.

    Article  CAS  Google Scholar 

  6. Loomans, E.E.M.G., Van, W.J., Koets, M., and Van, A.A., J. Agric. Food Chem., 2003, vol. 51, p.587.

    Article  CAS  Google Scholar 

  7. Finberg, R.W., Moellering, R.C., Tally, F.P., Craig, W.A., Pankey, G.A., et al., Clin. Infect. Dis., 2004, vol. 39, p. 1314.

    Article  CAS  Google Scholar 

  8. McCracken, G.H., Am. J. Med., 1986, vol. 80, no. 6B, p.172.

    Article  Google Scholar 

  9. Federal Law of Russian Federation no. 88-FZ “Technical normative for quality of milk and diary products.” http://www.rg.ru/2008/06/20/reglamentdok.html. Cited January 28, 2015.

  10. Gentamicin Summary Report, London: Eur. Agency Evaluation Med. Prod., Com. Vet. Med. Prod., 2001.

  11. Heller, D.N., Clar, S.B., and Righter, H.F., J. Mass Spectrosc., 2000, vol. 35, p.39.

    Article  CAS  Google Scholar 

  12. Robert, C., Gillard, N., Brasseur, P.-Y., Ralet, N., Dubois, M., and Delahaut, P., Food Control, 2015, vol. 50, p.509.

    Article  CAS  Google Scholar 

  13. Bijleveld, Y., Haanb, T., Toerschea, J., Jorjani, S., and Leec, J., J. Chromatogr. B, 2014, vol. 951-951, p.110.

    Google Scholar 

  14. Holthoona, F.L., Essersa, M.L., Muldera, P.J., Steadb, S.L., Caldowb, M., et al., Anal. Chim. Acta, 2009, vol. 637, p.135.

    Article  Google Scholar 

  15. Stead, D.A., J. Chromatogr. B, 2009, vol. 747, p.69.

    Article  Google Scholar 

  16. Omar, M.A., Nagy, D.M., Hammad, M.A., and Aly, A.A., J. Appl. Pharm. Sci., 2013, vol. 3, p.151.

    Google Scholar 

  17. Shachneva, E.Yu., Astrakh. Vestn. Ekol. Obraz., 2013, vol. 25, p.103.

    Google Scholar 

  18. Frutos, P., Torrado, S., Perez-Lorenzo, M.E., and Frutos, G., J. Pharm. Biomed. Anal., 2000, vol. 21, p. 1149.

    Article  CAS  Google Scholar 

  19. Caglayan, M.G. and Onur, F., Spectrosc. Lett., 2014, vol. 47, p.771.

    Article  CAS  Google Scholar 

  20. Levin, G.I. and Sosnina, L.N., Antib. Khimioter., 2014, vol. 59, p.10.

    CAS  Google Scholar 

  21. Ni, Y., Xia, Z., and Kokot, S., Curr. Anal. Chem., 2012, vol. 8, p.382.

    Article  CAS  Google Scholar 

  22. Zaubitzer, F., Buryak, A., and Severin, K., Chem. Eur. J., 2006, vol. 12, p. 3928.

    Article  CAS  Google Scholar 

  23. Confino, M. and Bontchev, P., Mikrochim. Acta, 1990, vol. 3, p.305.

    Article  CAS  Google Scholar 

  24. Ogun, S. and Miki, Y., J. Chromatogr. B, 1996, vol. 686, p.205.

    Article  Google Scholar 

  25. Sanchez-Martinez, M.L., Aguilar-Caballos, M.P., and Gomez-Hens, A., J. Pharm. Biomed., 2004, vol. 34, p. 1021.

    Article  CAS  Google Scholar 

  26. Omar, M.A., Nagy, D.M., Hammad, M.A., and Aly, A.A., Pharm. Sci. Technol., 2013, vol. 12, p.828.

    Article  Google Scholar 

  27. Florea, M., Monciu, C.-M., and Ilie, M., Farmacia, 2014, vol. 62, p.318.

    CAS  Google Scholar 

  28. Wenli, H., Fei, Q., Jingchuan, S., Wei, L., Junqing, Y., and Qing, M., Curr. Pharm. Anal., 2014, vol. 10, p.105.

    Article  Google Scholar 

  29. Liu, S., Hu, X., and Liu, Z., Sci. China. B, 2006, vol. 49, p.507.

    Article  CAS  Google Scholar 

  30. Liu, Z., Liu, S., Wang, L., Peng, J., and He, Y., Spectrochim. Acta A, 2009, vol. 74, p.36.

    Article  Google Scholar 

  31. Wang, L., Peng, J., Liu, Z., and He, Y., Luminescence, 2010, vol. 25, p.424.

    Article  CAS  Google Scholar 

  32. Sanchez-Martinez, M.L., Aguilar-Caballos, M.P., and Gomez-Hens, A., Talanta, 2009, vol. 78, p.305.

    Article  CAS  Google Scholar 

  33. Yamamoto, C.H. and Pinto T.J.A., J. AOAC Int., 1996, vol. 79, p.434.

    CAS  Google Scholar 

  34. Sehgal, D. and Vijey, I.K., Anal. Biochem., 1994, vol. 218, p.87.

    Article  CAS  Google Scholar 

  35. http://www.covachem.com/pibs/edc_sulfo_nhs_protocol.pdf. Cited January 28, 2015.

  36. Cooper, C.L., Dubin, P.L., Kayitmazer, A.B., and Turksen, S., Curr. Opin. Colloid Interface Sci., 2005, vol. 10, p.52.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, Moscow, 119991, Russia

    T. O. Samarina & M. K. Beklemishev

Authors
  1. T. O. Samarina
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  2. M. K. Beklemishev
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Correspondence to M. K. Beklemishev.

Additional information

Original Russian Text © T.O. Samarina, M.K. Beklemishev, 2015, published in Vestnik Moskovskogo Universiteta. Khimiya, 2015, No. 5, pp. 279–285.

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Samarina, T.O., Beklemishev, M.K. Determination of amikacin by Rayleigh scattering method based on the covalent bonding of the analyte with a water soluble polymer. Moscow Univ. Chem. Bull. 70, 223–228 (2015). https://doi.org/10.3103/S0027131415050107

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  • DOI: https://doi.org/10.3103/S0027131415050107

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