Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis

Authors

  • Kristine Rossbach
  • Katharina Wahle
  • Gustav Bruer
  • Ralph Brehm
  • Marion Langeheine
  • Kristina Rode
  • Katrin Schaper-Gerhardt
  • Ralf Gutzmer
  • Thomas Werfel
  • Manfred Kietzmann
  • Wolfgang Bäumer

DOI:

https://doi.org/10.2340/00015555-3674

Keywords:

histamine, psoriasis, itch, H2 receptor, H4 receptor

Abstract

Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied by itch. Histamine, acting via histamine 1?4 receptors, is known to modulate immune responses in the skin and to induce itch. The aim of this study was to test the role of histamine 2 receptors and histamine 4 receptors in the imiquimod-induced psoriasis-like skin inflammation model. BALB/c mice were treated intraperitoneally with amthamine (histamine 2 receptor agonist), JNJ-39758979 (histamine 4 receptor antagonist), a combination of both, or vehicle twice daily in a preventive manner. Imiquimod was applied once daily onto the back skin for 10 consecutive days. Stimulation of histamine 2 receptors and blockade of histamine 4 receptors ameliorated imiquimod-induced skin inflammation. The combination of amthamine and JNJ-39758979 reduced skin inflammation even more pronounced, diminished epidermal hyperproliferation, and inhibited spontaneous scratching behaviour. A combination of histamine 2 receptor agonist and histamine 4 receptor antagonists could represent a new strategy for the treatment of psoriasis.

Downloads

Download data is not yet available.

Additional Files

Published

2020-12-09

How to Cite

Rossbach, K., Wahle, K., Bruer, G., Brehm, R., Langeheine, M., Rode, K., Schaper-Gerhardt, K., Gutzmer, R., Werfel, T., Kietzmann, M., & Bäumer, W. (2020). Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis. Acta Dermato-Venereologica, 100(19), 1–8. https://doi.org/10.2340/00015555-3674

Issue

Section

Articles