Abstract
In multicellular organisms, apoptosis, also known as programmed cell death, is an important physiological response to eliminate unnecessary, excess, or harmful cells. Apoptosis occurs during embryonic development and is important in maintaining homeostasis during adulthood. Apoptosis also plays critical roles in angiogenesis and vessel regression. During these processes, activation of the apoptotic signaling pathway in endothelial cells mediates cell death. Several molecules, including growth factors and cytokines, produced by endothelial cells and other cells, regulate endothelial cell survival and apoptosis. Understanding the regulation of apoptosis is of great importance for determining the physiological role of endothelial cells and for developing novel therapeutic strategies. This review highlights the rapidly accumulating knowledge regarding endothelial cell death and provides insight into the molecular mechanisms regulating apoptosis and survival of endothelial cells.
Keywords: akt, angiogenesis, apoptosis, caspase-8, c-flip, death receptor, endothelial cell, mitochondria
Current Neurovascular Research
Title: Regulation of Endothelial Cell Death and Its Role in Angiogenesis and Vascular Regression
Volume: 1 Issue: 4
Author(s): Kazuhiro Sakamaki
Affiliation:
Keywords: akt, angiogenesis, apoptosis, caspase-8, c-flip, death receptor, endothelial cell, mitochondria
Abstract: In multicellular organisms, apoptosis, also known as programmed cell death, is an important physiological response to eliminate unnecessary, excess, or harmful cells. Apoptosis occurs during embryonic development and is important in maintaining homeostasis during adulthood. Apoptosis also plays critical roles in angiogenesis and vessel regression. During these processes, activation of the apoptotic signaling pathway in endothelial cells mediates cell death. Several molecules, including growth factors and cytokines, produced by endothelial cells and other cells, regulate endothelial cell survival and apoptosis. Understanding the regulation of apoptosis is of great importance for determining the physiological role of endothelial cells and for developing novel therapeutic strategies. This review highlights the rapidly accumulating knowledge regarding endothelial cell death and provides insight into the molecular mechanisms regulating apoptosis and survival of endothelial cells.
Export Options
About this article
Cite this article as:
Sakamaki Kazuhiro, Regulation of Endothelial Cell Death and Its Role in Angiogenesis and Vascular Regression, Current Neurovascular Research 2004; 1 (4) . https://dx.doi.org/10.2174/1567202043362072
DOI https://dx.doi.org/10.2174/1567202043362072 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
B-Type Natriuretic Peptide: Endogenous Regulator of Myocardial Structure, Biomarker and Therapeutic Target
Current Molecular Medicine Exploitation of Some Natural Products for the Prevention and/or Nutritional Treatment of SARS-CoV2 Infection
Endocrine, Metabolic & Immune Disorders - Drug Targets Do Not Say Ever Never More: The Ins and Outs of Antiangiogenic Therapies
Current Pharmaceutical Design Editorial (Thematic Issue: Inevitable Role of Traditional Systems of Medicine in Managing Non-Communicable Diseases (NCD))
Current Traditional Medicine Chemokines and Receptors as Targets in Anti-Inflammatory Therapy
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Management of Incidental Findings in the Era of Next-generation Sequencing
Current Genomics Pharmacological, Immunological, and Gene Targeting of the Renin-Angiotensin System for Treatment of Cardiovascular Disease
Current Pharmaceutical Design Centralized and Local Color Doppler Ultrasound Reading Agreement for Diagnosis of the Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis
Current Neurovascular Research Diabetes and Chronic Heart Failure: From Diabetic Cardiomyopathy to Therapeutic Approach
Endocrine, Metabolic & Immune Disorders - Drug Targets Statins in Bacteremia, Sepsis and Pneumonia: Have We Found the Holy Grail?
Recent Patents on Inflammation & Allergy Drug Discovery Molecular Targets of Diabetic Cardiovascular Complications
Current Drug Targets Vulnerable Atherosclerotic Plaque: Clinical Implications
Current Vascular Pharmacology Markers of Arrhythmogenic Risk in Hypertensive Subjects
Current Pharmaceutical Design Editorial: Modifying Cardiovascular Risk Factors: Acquired Topics and Emerging Concepts
Current Pharmaceutical Design A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes
Current Pharmaceutical Design Adipose Tissue and Bone Marrow as Sources for Cell-based Therapeutic Angiogenesis in Ischemic Tissues: Biological Foundation and Clinical Prospects for Age-related Vascular Disease
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Interstitial Lung Disease Associated with Polymyositis-Dermatomyositis
Current Respiratory Medicine Reviews Chronotherapeutic Drug Delivery Systems - An Approach to Circadian Rhythms Diseases
Current Drug Delivery Oral Antiplatelet Therapy for Acute Coronary Syndromes: Aspirin, P2Y12 Inhibition and Thrombin Receptor Antagonists
Current Drug Targets The Molecular Basis of the Interplay between Endothelin-1 and Nitric Oxide and its Relevance for Atherosclerosis and Arterial and Pulmonary Hypertension
Vascular Disease Prevention (Discontinued)