Abstract
Natural products have been the single most productive source of leads for the development of drugs, because of the great variety of their chemical structures. Previous chemical investigation of members of the genus Cystoseira resulted in the discovery of various bioactive secondary metabolites. The secondary metabolites isolated and characterized are very interesting, both from the biological activity and structural complexity points of view, which make this genus an attractive target for further investigations. The present review covers the research progress on natural products isolated from this genus since January 1995 until now, concerning the isolation and structural elucidation of the secondary metabolites from Cystoseira species. In this contribution significant biological properties are briefly discussed. Simultaneously, we gradually construct an intra-molecular pathway that logically interrelates the isolated compounds.
Keywords: Cystoseira, meroterpenoids, tetraprenyltoluquinols, sesquiterpenes, diterpenes, antimicrobial activity, cytotoxicity.
Mini-Reviews in Medicinal Chemistry
Title:Di- and Sesquiterpenoids from Cystoseira Genus: Structure, Intra-molecular Transformations and Biological Activity
Volume: 13 Issue: 8
Author(s): Vera Gouveia, Ana M. L. Seca, M. Carmo Barreto and Diana C.G.A. Pinto
Affiliation:
Keywords: Cystoseira, meroterpenoids, tetraprenyltoluquinols, sesquiterpenes, diterpenes, antimicrobial activity, cytotoxicity.
Abstract: Natural products have been the single most productive source of leads for the development of drugs, because of the great variety of their chemical structures. Previous chemical investigation of members of the genus Cystoseira resulted in the discovery of various bioactive secondary metabolites. The secondary metabolites isolated and characterized are very interesting, both from the biological activity and structural complexity points of view, which make this genus an attractive target for further investigations. The present review covers the research progress on natural products isolated from this genus since January 1995 until now, concerning the isolation and structural elucidation of the secondary metabolites from Cystoseira species. In this contribution significant biological properties are briefly discussed. Simultaneously, we gradually construct an intra-molecular pathway that logically interrelates the isolated compounds.
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Gouveia Vera, Seca Ana M. L., Barreto M. Carmo and Pinto Diana C.G.A., Di- and Sesquiterpenoids from Cystoseira Genus: Structure, Intra-molecular Transformations and Biological Activity, Mini-Reviews in Medicinal Chemistry 2013; 13 (8) . https://dx.doi.org/10.2174/1389557511313080003
DOI https://dx.doi.org/10.2174/1389557511313080003 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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