Abstract
Aberrant Ret kinase activity has been implicated in multiple carcinomas and disorders. Many strategies have been implemented to identify Ret kinase inhibitors. This review details current efforts to discover novel small molecule Ret kinase inhibitiors. Furthermore, we compile a comprehensive list of Ret kinase inhibitors and describe clinical results of advanced assets with Ret inhibitory activity.
Keywords: Ret kinase, protein tyrosine kinase inhibitors, thyroid cancer
Mini-Reviews in Medicinal Chemistry
Title: Current Review of Small Molecule Ret Kinase Inhibitors
Volume: 10 Issue: 2
Author(s): W.J. Zuercher, B.J. Turunen and K.E. Lackey
Affiliation:
Keywords: Ret kinase, protein tyrosine kinase inhibitors, thyroid cancer
Abstract: Aberrant Ret kinase activity has been implicated in multiple carcinomas and disorders. Many strategies have been implemented to identify Ret kinase inhibitors. This review details current efforts to discover novel small molecule Ret kinase inhibitiors. Furthermore, we compile a comprehensive list of Ret kinase inhibitors and describe clinical results of advanced assets with Ret inhibitory activity.
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Cite this article as:
Zuercher W.J., Turunen B.J. and Lackey K.E., Current Review of Small Molecule Ret Kinase Inhibitors, Mini-Reviews in Medicinal Chemistry 2010; 10 (2) . https://dx.doi.org/10.2174/138955710791185154
DOI https://dx.doi.org/10.2174/138955710791185154 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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