Abstract
Quinoxaline, quinazoline and benzimidazole based templates have been synthesized on solid-support employing different methodologies. This review enlightens academic and industrial examples of combinatorial synthesis for this type of heterocycles that appeared in the literature in the last decade. Hence, some of the important synthetic strategies for the generation of quinoxaline, quinazoline and benzimidazole based privileged structures, and the important biological activities for these heterocycles have been highlighted. Further, benzothiadiazinone, thioxoquinazolinone, cinnoline and indazole are also examined in this review.
Keywords: benzodiazepine receptor, solid support, Quinazoline derivatives, cell adhesion receptor, cyclocondensation, fibrinogen receptor antagonists, Rink-amide resin
Mini-Reviews in Medicinal Chemistry
Title: Recent Advances in the Solid-Phase Combinatorial Synthetic Strategies for the Quinoxaline, Quinazoline and Benzimidazole Based Privileged Structures
Volume: 6 Issue: 1
Author(s): Ahmed Kamal, K. L. Reddy, V. Devaiah, N. Shankaraiah and M. V. Rao
Affiliation:
Keywords: benzodiazepine receptor, solid support, Quinazoline derivatives, cell adhesion receptor, cyclocondensation, fibrinogen receptor antagonists, Rink-amide resin
Abstract: Quinoxaline, quinazoline and benzimidazole based templates have been synthesized on solid-support employing different methodologies. This review enlightens academic and industrial examples of combinatorial synthesis for this type of heterocycles that appeared in the literature in the last decade. Hence, some of the important synthetic strategies for the generation of quinoxaline, quinazoline and benzimidazole based privileged structures, and the important biological activities for these heterocycles have been highlighted. Further, benzothiadiazinone, thioxoquinazolinone, cinnoline and indazole are also examined in this review.
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Cite this article as:
Kamal Ahmed, Reddy L. K., Devaiah V., Shankaraiah N. and Rao V. M., Recent Advances in the Solid-Phase Combinatorial Synthetic Strategies for the Quinoxaline, Quinazoline and Benzimidazole Based Privileged Structures, Mini-Reviews in Medicinal Chemistry 2006; 6 (1) . https://dx.doi.org/10.2174/138955706775197839
DOI https://dx.doi.org/10.2174/138955706775197839 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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