Abstract
Quinones still comprise one of the largest classes of antitumour agents. For example, the anthracycline antibiotics are among the most utilised anticancer agents ever developed. Many other quinones were tested for their anticancer activity. Though there are general and well-established mechanisms for quinone toxicity, the exact contribution of the quinone moiety to the cytotoxic effect remains frequently uncertain. However, DNA represents the main target for quinoid antitumour agents and most of them belong to the groups of DNA intercalating and/ or alkylating agents. But also other cellular structures such as heat shock protein 90 or telomerase have been identified as targets for quinoid compounds.
Keywords: quinone, anticancer, anthracycline, aziridinylindolequinone, ansamycin, triptycene, rubromycin
Mini-Reviews in Medicinal Chemistry
Title: Antitumour Quinones
Volume: 5 Issue: 5
Author(s): C. Asche
Affiliation:
Keywords: quinone, anticancer, anthracycline, aziridinylindolequinone, ansamycin, triptycene, rubromycin
Abstract: Quinones still comprise one of the largest classes of antitumour agents. For example, the anthracycline antibiotics are among the most utilised anticancer agents ever developed. Many other quinones were tested for their anticancer activity. Though there are general and well-established mechanisms for quinone toxicity, the exact contribution of the quinone moiety to the cytotoxic effect remains frequently uncertain. However, DNA represents the main target for quinoid antitumour agents and most of them belong to the groups of DNA intercalating and/ or alkylating agents. But also other cellular structures such as heat shock protein 90 or telomerase have been identified as targets for quinoid compounds.
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Cite this article as:
Asche C., Antitumour Quinones, Mini-Reviews in Medicinal Chemistry 2005; 5 (5) . https://dx.doi.org/10.2174/1389557053765556
DOI https://dx.doi.org/10.2174/1389557053765556 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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