Protein-inorganic Nanohybrids: A Potential Symbiosis in Tissue Engineering

Title:Protein-inorganic Nanohybrids: A Potential Symbiosis in Tissue Engineering

Volume: 19 Issue: 16

Author(s): May S. Freag*Ahmed O. Elzoghby

Affiliation:

• Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521,Egypt

Keywords: Hybrid nanoparticles, inorganic nanoparticles, natural polymers, proteins, tissue engineering, bone regeneration.

Abstract: Background: Recently, a great interest has been paid to the development of hybrid proteininorganic nanoparticles (NPs) for tissue engineering applications to combine the merits of both inorganic and protein nanocarriers.

Objective: This short review primarily discusses the most important advances in the application of the hybrids of proteins (gelatin, zein, silk fibroin,….etc) with inorganic NPs (calcium phosphate NPs, cadmium QDs, carbon nanotubes,…etc) in tissue engineering.

Results: Various strategies that have been utilized for the preparation of protein-functionalized inorganic NPs are discussed. Nanocomposite films, electrospun nanofibrous scaffolds, nanostructured colloidal composite gels and nanocomposite lyophilized sponges are among the most common platforms of protein-inorganic nanohybrid formulations used in regenerative medicine.

Conclusion: protein-inorganic nanohybrids could serve as promising platforms for different biomedical applications including bone and cartilage tissue regeneration, imaging of engineered tissues, development of antithrombogenic implant biomaterials and anti-bacterial wound dressing as well.

Cite this article as:

Freag S. May *, Elzoghby O. Ahmed , Protein-inorganic Nanohybrids: A Potential Symbiosis in Tissue Engineering, Current Drug Targets 2018; 19 (16) . https://dx.doi.org/10.2174/1389450118666171027111050