Abstract
The scenario of tuberculosis has gone deadly due to its high prevalence and emergence of widespread drug resistance. It is now high time to develop novel antimycobacterial strategies and to understand novel mechanisms of existing antimycobacterial compounds so that we are equipped with newer tuberculosis controlling molecules in the days to come. Iron has proven to be essential for pathogenesis of tuberculosis and retinoic acid is known to influence the iron metabolism pathway. Retenoic acid is also known to exhibit antitubercular effect in in vivo system. Therefore there is every possibility that retinoic acid by affecting the iron metabolism pathway exhibits its antimycobacterial effect. These aspects are reviewed in the present manuscript for understanding the antimycobacterial role of retinoic acid in the context of iron metabolism and other immunological aspects.
Keywords: Antitubercular drug, cholesterol, iron, phagosome, retinoic acid, tuberculosis.
Current Pharmaceutical Biotechnology
Title:Retinoic Acid and Iron Metabolism: A Step Towards Design of a Novel Antitubercular Drug
Volume: 15 Issue: 12
Author(s): Surajit Chakraborty, Rajasri Bhattacharyya, Kirtimaan Sayal and Dibyajyoti Banerjee
Affiliation:
Keywords: Antitubercular drug, cholesterol, iron, phagosome, retinoic acid, tuberculosis.
Abstract: The scenario of tuberculosis has gone deadly due to its high prevalence and emergence of widespread drug resistance. It is now high time to develop novel antimycobacterial strategies and to understand novel mechanisms of existing antimycobacterial compounds so that we are equipped with newer tuberculosis controlling molecules in the days to come. Iron has proven to be essential for pathogenesis of tuberculosis and retinoic acid is known to influence the iron metabolism pathway. Retenoic acid is also known to exhibit antitubercular effect in in vivo system. Therefore there is every possibility that retinoic acid by affecting the iron metabolism pathway exhibits its antimycobacterial effect. These aspects are reviewed in the present manuscript for understanding the antimycobacterial role of retinoic acid in the context of iron metabolism and other immunological aspects.
Export Options
About this article
Cite this article as:
Chakraborty Surajit, Bhattacharyya Rajasri, Sayal Kirtimaan and Banerjee Dibyajyoti, Retinoic Acid and Iron Metabolism: A Step Towards Design of a Novel Antitubercular Drug, Current Pharmaceutical Biotechnology 2014; 15 (12) . https://dx.doi.org/10.2174/1389201015666141126121639
DOI https://dx.doi.org/10.2174/1389201015666141126121639 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
MICA Gene and Relevance to Immune Responses in Organ Transplants and Inflammatory, Tumoral and Autoimmune Diseases
Current Immunology Reviews (Discontinued) Bactericidal Activity of Usnic Acid-Loaded Electrospun Fibers
Recent Patents on Nanotechnology Closing the Gap: An Atomistic Structural and Functional Perspective of S. <i>mansoni</i> Universal Stress G4LZI3 Protein in Complex with Phenolic Compounds
Current Drug Discovery Technologies Meet Our Editorial Board Member:
Current Pharmaceutical Biotechnology Application of Sugar-Base Anhydro Bridge for Modification of Nucleosides in the 2’- and/or 3’-Positions - Revisited
Current Organic Chemistry iMTBGO: An Algorithm for Integrating Metabolic Networks with Transcriptomes Based on Gene Ontology Analysis
Current Genomics Interaction Mechanisms of Inorganic Nanoparticles and Biomolecular Systems of Microorganisms
Current Chemical Biology Synthesis, In silico Molecular Docking and Pharmacokinetic Studies, In vitro Antimycobacterial and Antimicrobial Studies of New Imidozolones Clubbed with Thiazolidinedione
Current Computer-Aided Drug Design Non-Membrane Permeabilizing Modes of Action of Antimicrobial Peptides on Bacteria
Current Topics in Medicinal Chemistry Epoxide Hydrolases and their Application in Organic Synthesis
Current Organic Chemistry The Comparison of Pleural Fluid TNF-α and IL-10 Levels with ADA in Tuberculous Pleural Effusion
Current Medicinal Chemistry DESIGN, <i>In silico</i> Modeling, Toxicity study and Synthesis of Novel Substituted Semicarbazide Derivatives of Pyrimidine: An Antitubercular Agent
Current Bioactive Compounds B-Cell Based Gene Therapy for Autoimmune Diseases
Infectious Disorders - Drug Targets Hypoxia Inducible Factor Stabilization As a Novel Strategy to Treat Anemia
Current Medicinal Chemistry Application of Metabolomics in Drug Discovery, Development and Theranostics
Current Metabolomics Pneumococcal Infections at Hajj: Current Knowledge Gaps
Infectious Disorders - Drug Targets Tumour Mutation Profiling with High-throughput Multiplexed Genotyping: A Review of its Use for Guiding Targeted Cancer Therapy
Current Cancer Therapy Reviews Advances in Antimicrobial Natural Products Derived from Marine Actinomycetes
Mini-Reviews in Organic Chemistry p-Benzoquinone as a Privileged Scaffold of Pharmacological Significance: A Review
Mini-Reviews in Medicinal Chemistry Anti-TNF Treatment in Rheumatoid Arthritis
Current Pharmaceutical Design