Abstract
Aromatic oligoamide foldamers whose helical structures were stabilized by intramolecular hydrogen bindings between consecutive units not only can mimic the secondary or tertiary structures of its natural counterparts but also provide alternative approaches to study the properties of biopolymers in artificial systems. Aromatic oligoamide foldamers are sequence-specific oligomers as demonstrated in peptides and DNA, while variation of orientation and size of aromatic monomers and lengths of oligomers can generate many foldamers with desirable structures and in turn lead to different properties. In this article, we illustrate the structure-property relationships of aromatic oligoamide foldamers reported by us and collaborators.
Keywords: Aromatic oligoamides, foldamers, hydrogen bonds, helices, helical capsules, self-assembly, helical structures, double helices, biological activities, selfassembly, Homodouble helices, Heterodouble helices, NMR spectroscopy, DMSO, NOESY, H DOSY, F NMR
Current Organic Chemistry
Title: Aromatic Oligoamide Foldamers: A Paradigm for Structure – Property Relationship
Volume: 15 Issue: 9
Author(s): Quan Gan, Ying Wang and Hua Jiang
Affiliation:
Keywords: Aromatic oligoamides, foldamers, hydrogen bonds, helices, helical capsules, self-assembly, helical structures, double helices, biological activities, selfassembly, Homodouble helices, Heterodouble helices, NMR spectroscopy, DMSO, NOESY, H DOSY, F NMR
Abstract: Aromatic oligoamide foldamers whose helical structures were stabilized by intramolecular hydrogen bindings between consecutive units not only can mimic the secondary or tertiary structures of its natural counterparts but also provide alternative approaches to study the properties of biopolymers in artificial systems. Aromatic oligoamide foldamers are sequence-specific oligomers as demonstrated in peptides and DNA, while variation of orientation and size of aromatic monomers and lengths of oligomers can generate many foldamers with desirable structures and in turn lead to different properties. In this article, we illustrate the structure-property relationships of aromatic oligoamide foldamers reported by us and collaborators.
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Cite this article as:
Gan Quan, Wang Ying and Jiang Hua, Aromatic Oligoamide Foldamers: A Paradigm for Structure – Property Relationship, Current Organic Chemistry 2011; 15 (9) . https://dx.doi.org/10.2174/138527211795378227
DOI https://dx.doi.org/10.2174/138527211795378227 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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