Abstract
Heparin and low molecular weight heparins are major clinical anticoagulants and the drugs of choice for the treatment of deep venous thrombosis. The discovery of an antithrombin binding domain in heparin focused interest on understanding the mechanism of heparins antithrombotic / anticoagulant activity. Various heparin-mimetic oligosaccharides have been prepared in an effort to replace polydisperse heparin and low molecular weight heparins with a structurally-defined anticoagulant. The goal of attaining a heparin-mimetic with no unwanted side-effects has also provided motivation for these efforts. This article reviews structure-activity relationship (SAR) of structurally-defined heparin-mimetic oligosaccharides.
Keywords: heparin, anticoagulant, antithrombotic, antithrombin III, heparin pentasaccharide, factor xa, thrombin, bisaldonic acid amides
Current Pharmaceutical Design
Title: Synthetic Oligosaccharides as Heparin-Mimetics Displaying Anticoagulant Properties
Volume: 9 Issue: 28
Author(s): Fikri Y. Avci, Nathalie A. Karst and Robert J. Linhardt
Affiliation:
Keywords: heparin, anticoagulant, antithrombotic, antithrombin III, heparin pentasaccharide, factor xa, thrombin, bisaldonic acid amides
Abstract: Heparin and low molecular weight heparins are major clinical anticoagulants and the drugs of choice for the treatment of deep venous thrombosis. The discovery of an antithrombin binding domain in heparin focused interest on understanding the mechanism of heparins antithrombotic / anticoagulant activity. Various heparin-mimetic oligosaccharides have been prepared in an effort to replace polydisperse heparin and low molecular weight heparins with a structurally-defined anticoagulant. The goal of attaining a heparin-mimetic with no unwanted side-effects has also provided motivation for these efforts. This article reviews structure-activity relationship (SAR) of structurally-defined heparin-mimetic oligosaccharides.
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Cite this article as:
Avci Y. Fikri, Karst A. Nathalie and Linhardt J. Robert, Synthetic Oligosaccharides as Heparin-Mimetics Displaying Anticoagulant Properties, Current Pharmaceutical Design 2003; 9 (28) . https://dx.doi.org/10.2174/1381612033453929
DOI https://dx.doi.org/10.2174/1381612033453929 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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