Abstract
Nanoparticulate-based drug carriers have been developed to overcome the problems of conventional anticancer pharmacotherapy, i.e., the little specificity and low accumulation of the drug into the tumor interstitium, and the extensive biodistribution leading to severe toxicity. Unfortunately, conventional nanoparticles have been demonstrated to merely accumulate the loaded drug into organs associated to the reticuloendothelial system, e.g., the liver. Recently, drug delivery strategies involving the use of nanoplatforms surface decorated with unique biomolecules have demonstrated their potential in concentrating the chemotherapy agent specifically into the malignant cells. This review will be focused on the analysis of the current state of the art and future perspectives of such passive and active targeting strategies based on the enhanced permeability and retention effect and on a ligand-mediated transport, respectively. Special attention will be given to the use of these surface functionalized nanocarriers to overcome multi-drug resistances in cancer cells.
Keywords: Active drug targeting, cancer, EPR effect, ligand-mediated delivery, multi-drug resistance, nanoparticle, passive drug targeting, Nanoparticulate-based, conventional anticancer, pharmacotherapy
Current Medicinal Chemistry
Title:Drug Targeting to Cancer by Nanoparticles Surface Functionalized with Special Biomolecules
Volume: 19 Issue: 19
Author(s): M. A. Holgado, L. Martin-Banderas, J. Alvarez-Fuentes, M. Fernandez-Arevalo and J. L. Arias
Affiliation:
Keywords: Active drug targeting, cancer, EPR effect, ligand-mediated delivery, multi-drug resistance, nanoparticle, passive drug targeting, Nanoparticulate-based, conventional anticancer, pharmacotherapy
Abstract: Nanoparticulate-based drug carriers have been developed to overcome the problems of conventional anticancer pharmacotherapy, i.e., the little specificity and low accumulation of the drug into the tumor interstitium, and the extensive biodistribution leading to severe toxicity. Unfortunately, conventional nanoparticles have been demonstrated to merely accumulate the loaded drug into organs associated to the reticuloendothelial system, e.g., the liver. Recently, drug delivery strategies involving the use of nanoplatforms surface decorated with unique biomolecules have demonstrated their potential in concentrating the chemotherapy agent specifically into the malignant cells. This review will be focused on the analysis of the current state of the art and future perspectives of such passive and active targeting strategies based on the enhanced permeability and retention effect and on a ligand-mediated transport, respectively. Special attention will be given to the use of these surface functionalized nanocarriers to overcome multi-drug resistances in cancer cells.
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Cite this article as:
A. Holgado M., Martin-Banderas L., Alvarez-Fuentes J., Fernandez-Arevalo M. and L. Arias J., Drug Targeting to Cancer by Nanoparticles Surface Functionalized with Special Biomolecules, Current Medicinal Chemistry 2012; 19 (19) . https://dx.doi.org/10.2174/092986712800784720
DOI https://dx.doi.org/10.2174/092986712800784720 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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