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Entrapment of bioactive molecules in poly (alkylcyanoacrylate) nanoparticles

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American Journal of Drug Delivery

Abstract

Poly (alkylcyanoacrylate) [PACA] nanoparticles have been studied since the early 1980s as possible colloidal drug delivery systems. Several excellent general reviews have since been published on this subject. This review focuses on the use of the two different methods (encapsulation and sorption) for the entrapment of drugs and model compounds in PACA nanoparticles. The term encapsulation is used when the drug or model compound is added at the same time or before the monomer to the polymerization template. The term sorption is used when the compound is added after the polymerization has taken place. High drug entrapment can be achieved with both methods and the method of entrapment (encapsulation or sorption) should be chosen depending on the type of drug to be entrapped and the method of particle preparation (interfacial polymerization of a coarse emulsion or a microemulsion or micellar polymerization). The type, chain length, and amount of monomer used for the polymerization as well as possible interactions of the compound with the monomer during polymerization should also be considered in the choice of entrapment method and these can also influence the extent of encapsulation.

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Notes

  1. The use of trade names is for product identification purposes only and does not imply endorsement.

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Acknowledgment

The authors would like to thank the School of Pharmacy, University of Otago, for supplying a scholarship to Karen Krauel, the University of Otago for supplying a scholarship to Tasana Pitaksuteepong and the New Zealand Pharmacy Education and Research Foundation and Otago Research Grants for funding aspects of the work described. The authors have no conflicts of interest that are directly relevant to the content of this manuscript.

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Authors and Affiliations

  1. School of Pharmacy, University of Otago, Drug Delivery Solutions, Dunedin, New Zealand

    Karen Krauel & Thomas Rades

  2. Department of Pharmaceutical Technology, Naresuan University, Faculty of Pharmaceutical Sciences, Phitsanulok, Thailand

    Tasana Pitaksuteepong

  3. School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia

    Nigel M. Davies

  4. School of Pharmacy, University of Otago, PO Box 913, Dunedin, New Zealand

    Karen Krauel

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  1. Karen Krauel
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  2. Tasana Pitaksuteepong
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  3. Nigel M. Davies
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  4. Thomas Rades
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Correspondence to Karen Krauel.

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Krauel, K., Pitaksuteepong, T., Davies, N.M. et al. Entrapment of bioactive molecules in poly (alkylcyanoacrylate) nanoparticles. Am J Drug Deliv 2, 251–259 (2004). https://doi.org/10.2165/00137696-200402040-00005

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