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Analgesics, Allergy and Asthma

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Summary

Intolerance to analgesics is common in patients with bronchial asthma, nasal polyps and urticaria. Symptoms of intolerance resemble those of allergy, but the events precipitating them can rarely be traced to reactions between the drug and a specific antibody or sensitised T-lymphocytes. In 8 to 20% of adult asthmatics, aspirin and several other analgesics provoke asthmatic attacks, probably through inhibition of cyclo-oxygenase. This is a distinct and important clinical syndrome with a specific history, course and clinial presentation and a number of unique peculiarities which still require elucidation at the biochemical level.

Up to 40% of patients with chronic urticaria develop an obvious increase in weals and swelling after taking aspirin. These reactions occur only when urticaria is active, and though the reason for them is not known, it appears that different mechanisms may be responsible in different patients. Skin reactions other than exacerbation of chronic urticaria are less common, but may create serious clinical problems.

The clinical background of a patient often determines the type of adverse response to an analgesic. Thus, in certain individuals, analgesics can produce anaphylactic reactions and/or urticaria, probably through an immunological mechanism, while in some asthmatics they precipitate bronchoconstriction, probably through inhibition of bronchial cyclo-oxygenase. Study of untoward reactions to analgesics not only leads to safer pharmacotherapy, but it also offers a fascinating model for better understanding of some diseases.

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References

  • Antépara, I.; Martin-Gil, D.; Dominguez, Maria-A. and Oehling, A.: Adverse drug reactions produced by analgetic drugs. Allergologica et Immunopathologica 9(6): 545–554 (1981).

    Google Scholar 

  • Asad, S.I.; Kemeny, D.M.; Youlten, L.J.F.; Frankland, A.W. and Lessof, M.H.: Effect of aspirin in “aspirin sensitive” patients. British Medical Journal 288: 745–749 (1984).

    PubMed  CAS  Google Scholar 

  • Baldocchi, G.; Verfloet, D. and Charpin, J.: Acetyl-salicylic acid therapy in aspirin-sensitive asthmatics. Journal of Allergy and Clinical Immunology 71: 148 (1983).

    Google Scholar 

  • Basomba, A.; Romar, A.; Pelaez, A.; Villamanzo, I.G. and Campos, A.: The effect of sodium cromoglycate in preventing aspirin-induced bronchospasm. Clinical Allergy 6: 269–275 (1976).

    PubMed  CAS  Google Scholar 

  • Bianco, S.; Robuschi, M. and Petrigni, G.: Aspirin-induced tolerance in aspirin-asthma detected by a new challenge technique. IRCS Journal of Medical Sciences 5: 129–130 (1977a).

    Google Scholar 

  • Bianco, S.; Robuschi, M.; Petrigni, G. and Allegra, L.: Respiratory effects due to aspirin (ASA): ASA-induced tolerance in ASA-asthmatic patients. Bulletin Européen de Physiopathologic Respiratoire 13: 123–124 (1977b).

    Google Scholar 

  • Bianco, S.; Robuschi, M. and Petrigni, G.: Treatment of aspirin idiosyncracy (letter). Journal of Allergy and Clinical Immunology 70: 222 (1982).

    Google Scholar 

  • Bundgaard, H. and de Weck, A.L.: The role of aminoreactive impurities in acetylsalicylic acid allergy. International Archives of Allergy and Applied Immunology 49: 119–125 (1975).

    CAS  Google Scholar 

  • Cant, A.J.; Gibson, P. and Dancy, M.: Food hypersensitivity made life-threatening by ingestion of aspirin. British Medical Journal 288: 755–756 (1984).

    PubMed  CAS  Google Scholar 

  • Capron, A.; Ameisen, J.C.; Joseph, M.; Auriault, C.; Tonnel, A.B.; Caen, J.: New functions for platelets and their pathological implications. International Archives of Allergy and Applied Immunology 77: 107–114 (1985).

    PubMed  CAS  Google Scholar 

  • Ceserani, R.; Colombo, M.; Robuschi, M. and Bianco, S.: Tartrazine and prostaglandin system. Prostaglandins and Medicine 1: 499–502 (1978).

    PubMed  CAS  Google Scholar 

  • Chiu, J.T.: Improvement in aspirin-sensitive asthmatic subjects after rapid aspirin desensitization and aspirin maintenance (ADAM) treatment. Journal of Allergy and Clinical Immunology 71: 560–564 (1983).

    PubMed  CAS  Google Scholar 

  • Conti, L; Fidani, P.; Chistolini, A.; Francesconi, M.; Gandolfo, G.M. and Mazzucconi, M.G.: Detection of drug-dependent IgG antibodies with antiplatelet activity by the antiglobulin consumption assay. Haemostatis 14: 480–486 (1984).

    CAS  Google Scholar 

  • Czerniawska-Mysik, G. and Szczeklik, A.: Idiosyncrasy to pyrazolone drugs. Allergy 36: 381–384 (1981).

    PubMed  CAS  Google Scholar 

  • Dahl, R.: Oral and inhaled sodium cromoglycate in challenge test with food allergens or acetylsalicylic acid. Allergy 36: 161–165 (1981).

    PubMed  CAS  Google Scholar 

  • Delaney, J.C.: Asthma, nasal polyposis, and aspirin sensitivity. Annals of Internal Medicine 79: 761–764 (1973).

    PubMed  CAS  Google Scholar 

  • Delaney, J.C.: The effect of ketotifen on aspirin-induced asthmatic reactions. Clinical Allergy 13: 247–251 (1983).

    PubMed  CAS  Google Scholar 

  • Della Torre, F.; Bellani, M. and Mergalli, M.: Syndrome purpurica indotta dall’acido acetilsalicilico: Due casi clinici. Rassarcione Geriatrice 17: 35 (1981).

    Google Scholar 

  • Del Favero, A.: Anti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout; in Dukes (Ed.) Side Effects of Drugs: Annual 7, pp. 104–124 (Excerpta Medica, Amsterdam 1983).

    Google Scholar 

  • De Sworte, R.D.: Drug allergy — problems and strategies. Journal of Allergy and Clinical Immunology 74: 209–221 (1984).

    Google Scholar 

  • Diffey, B.L.; Daymond, T.J. and Fairgreaves, H.: Phototaxic reactions to piroxicam, naproxen and tiaprofenic acid. British Journal of Rheumatology 22: 239–242 (1983).

    PubMed  CAS  Google Scholar 

  • Di Rosa, M.; Flower, R.J.; Hirata, F.; Parente, L. and Russo-Marie, F.: Anti-phospholipase proteins. Prostaglandins 28: 441–442 (1984).

    PubMed  Google Scholar 

  • Doeglas, H.M.G.: Chronic urticaria: Intolerance for aspirin and food additives and relationship to atopy. British Journal of Dermatology 108: 108 (1983).

    Google Scholar 

  • Dor, P.J.; Vervloet, D.; Baldocchi, G. and Charpin, J.: Aspirin intolerance and asthma induction of a tolerance and long-term monitoring. Clinical Allergy 15: 37–42 (1985).

    PubMed  CAS  Google Scholar 

  • Dux, S.; Groslop, I.; Garty, M. and Rosenfeld, J.B.: Anaphylactic shock induced by diclofenac. British Medical Journal 286: 1861 (1984).

    Google Scholar 

  • Falliers, C.J.: Familial coincidence of asthma, aspirin intolerance and nasal polyposis. Annals of Allergy 32: 65–69 (1974).

    PubMed  CAS  Google Scholar 

  • Farr, R.S.; Spector, S.L. and Wangaard, C.: Asthma and non-steroidal anti-inflammatory drugs. Annals of Internal Medicine 89: 577–699 (1978).

    PubMed  CAS  Google Scholar 

  • Fein, B.T.: Aspirin shock associated with asthma and nasal polyps. Annals of Allergy 29: 598–601 (1971).

    PubMed  CAS  Google Scholar 

  • Fry, L.: Drugs eruptions; in Dermatology: An Illustrated Guide, 3rd ed., pp. 81–85 (Butterworths, London 1984).

    Google Scholar 

  • Furuya, T.; Schido, N. and Ishikawa, F.: Beitrag zum fixen Arzneimittel exanthem. Archives of Dermatological Research 225: 375–380 (1966).

    Google Scholar 

  • Gérard, A.; Roche, G. and Presles, O.: Syndromes de Lyell medicamenteaux. Therapic 37: 475–480 (1982).

    Google Scholar 

  • Gebel, K. and Hornstein, O.P.: Drug-induced oral erythema multiforme: Results of a long-term retrospective study. Dermatologica 168: 35–40 (1984).

    PubMed  CAS  Google Scholar 

  • Gerber, J.G.; Payne, N.A.; Oelz, O.; Nies, A.S. and Oates, J.A.: Tartrazine and the prostaglandin system. Journal of Allergy and Clinical Immunology 63: 289–294 (1979).

    PubMed  CAS  Google Scholar 

  • Girard, J.-P. and Gumowski, P.: Allergic et intolérance aux médicaments anti-rheumatismaux. Medecine et Hygiene 41: 2801–2810 (1983).

    Google Scholar 

  • Godard, P.; Chaintreuil, J.; Damon, M.; Coupe, M.; Flandre, O.; Crastes de Paulet, A. and Michel, F.B.: Functional assessment of alveolar macrophages: Comparison of cells from asthmatics and normal subjects. Journal of Allergy and Clinical Immunology 70: 88–93 (1982).

    PubMed  CAS  Google Scholar 

  • Goetzl, E.J.; Valacer, D.J.; Payan, D.G. and Wong, M.Y.S.: Abnormal responses of leukocyte oxygenation of arachidonic acid in adults with aspirin intolerance. Journal of Allery and Clinical Immunology 77: 693–698 (1986).

    CAS  Google Scholar 

  • Granström, E. and Kindahl, H.: Circulating and urinary metabolites of PGE2 and PGF2α. Prostaglandins 27: 350–352 (1984).

    Google Scholar 

  • Gryglewski, R.J.; Panczenko, B.; Korbut, R.; Grodzinska, L. and Ocetkiewicz, A.: Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig. Prostaglandins 10: 343–355 (1975).

    PubMed  CAS  Google Scholar 

  • Gryglewski, R.J.; Szczeklik, A. and Nizankowska, E.: Aspirin-sensitive asthma: its relationship to inhibition of prostaglandin biosynthesis; in Berti, Samuelsson and Velo (Eds) Prostaglandins and Thromboxanes, pp. 191–203, NATO Advanced Study Institutes Series A: Life Sciences (Plenum Press, New York 1977).

    Google Scholar 

  • Gryglewski, R.J.; Szczeklik, A. and Czerniawska-Mysik, G.: Aspirin sensitivity: Other drugs. Annals of Internal Medicine 83: 286–287 (1975).

    Google Scholar 

  • Hanks, G.W.: Mild analgesics: A review of their efficacy, adverse effects and safety. 1. Aspirin. Clinical Therapeutics (Suppl. A): 1–23 (1982).

    Google Scholar 

  • Hanks, G.W.: Mild analgesics: A review of their efficacy, adverse effects and safety. 1. Aspirin. Clinical Therapeutics (Supplement A): 1–23 (1982).

    Google Scholar 

  • Hardy, C.C.; Robinson, C.; Tattersfield, A.E. and Holgate, S.T.: The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men. New England Journal of Medicine 311: 209–213 (1984).

    PubMed  CAS  Google Scholar 

  • Hollingsworth, H.M.; Downing, E.T.; Braman, S.S.; Glassroth, J.; Binder, R. and Center, D.M.: Identification and characterization of neutrophil chemotactic activity in aspirin-induced asthma. American Review of Respiratory Diseases 130: 373–379 (1984).

    CAS  Google Scholar 

  • Howard, A.; Dowling, J. and Vorigos, G.: Pseudoporphyria due to naproxen. Lancet 1: 819–820 (1985).

    PubMed  CAS  Google Scholar 

  • Hubert, D.; Habibi, B.; Krulik, M. and Debray, J.: Anémie hémolytique immunoallergique, thrombopénie et insuffisance rénale aiguë induites par l’aspirine. Presse Médicale 13(42): 2567–2569 (1984).

    CAS  Google Scholar 

  • Jones, D.H.; May, A.G. and Condemi, J.J.: HLA DR typing of aspirin sensitive asthmatics. Annals of Allergy 52: 87–89 (1984).

    PubMed  CAS  Google Scholar 

  • Juhlin, L.: Intolerance to food and drug additives; in de Weck and Bundgaard (Eds) Handbook of Experimental Pharmacology, vol. 63, pp. 643–665 (Springer Verlag, Berlin-Heidelberg-New York-Tokyo 1983).

    Google Scholar 

  • Juhlin, L.; Michaëlsson, G. and Zetterström, O.: Urticaria and asthma induced by food-and-drug additives in patients with aspirin hypersensitivity. Journal of Allergy and Clinical Immunology 50: 92–98 (1972).

    PubMed  CAS  Google Scholar 

  • Kennedy, C.B.; Davis, F.H.; Henington, V.M. and Sternberg, M.J.: Dermatitis medicamentosa due to antipyrine. A study of 28 cases in Negroes following the use of proprietary medications (66 cold preparations). Archives of Dermatology 72: 286–300 (1957).

    Google Scholar 

  • Knop, J. and Macher, E.: Vergleichende Untersuchungen über Haut- und orale Provokationstests bei Analgetika-Unverträglichkeit. Akta Dermatologika 10: 43–45 (1984).

    Google Scholar 

  • Kowalski, M.L.; Grzelewska-Rzymowska, J.; Rozniecki, J. and Szmidt, M.: Aspirin tolerance induced in aspirin-sensitive asthmatics. Allergy 39: 171–178 (1984).

    PubMed  CAS  Google Scholar 

  • Kuehl, F.A.; Dougherty, H.W. and Ham, E.A.: Interactions between prostaglandins and leukotrienes. Biochemical Pharmacology 33: 1–5 (1984).

    PubMed  CAS  Google Scholar 

  • Lewis, R.A.: Mastocytosis. Journal of Allergy and Clinical Immunology 74: 755–765 (1984).

    PubMed  CAS  Google Scholar 

  • Lockey, R.F.; Rucknagel, D.L. and Vaneslow, N.A.: Familial occurrence of asthma, nasal polyps and aspirin intolerance. Annals of Internal Medicine 78: 57–63 (1973).

    PubMed  CAS  Google Scholar 

  • Lumry, W.R.; Curd, J.G.; Brocklehurst, W.E.; Simon, R.A. and Stevenson, D.D.: Benoxaprofen, an inhibitor of arachidonic acid lipoxygenase, does not prevent aspirin sensitive asthma. (Abstract.) Journal of Allergy and Clinical Immunology 69: 93 (1982).

    Google Scholar 

  • Lumry, W.R.; Curd, J.G.; Zeiger, R.S.; Pleskow, W.W. and Stevenson, D.D.: Aspirin-sensitive rhinosinusitis: The clinical syndrome and effects of aspirin administration. Journal of Allergy and Clinical Immunology 71: 580–587 (1983).

    PubMed  CAS  Google Scholar 

  • Mandell, B.; Shen, H.S. and Hepburn, B.: Fever from ibuprofen in a patient with lupus erythematosus. Annals of Internal Medicine 85: 209–210 (1976).

    PubMed  CAS  Google Scholar 

  • Martelli, N.A. and Usandivaras, G.: Inhibition of aspirin-induced bronchoconstriction by sodium cromoglycate inhalation. Thorax 32: 684–690 (1977).

    PubMed  CAS  Google Scholar 

  • Matthews, J.I. and Stage, D.: Indomethacin, aspirin and urticaria. Annals of Internal Medicine 80: 771 (1974).

    PubMed  CAS  Google Scholar 

  • Maur, von K.; Adkinson, N.F. Jr; Metre, van T.E.; Marsh, D.G. and Norman, P.S.: Aspirin intolerance in a family. Journal of Allergy and Clinical Immunology 54: 380–389 (1974).

    Google Scholar 

  • Michaëlsson, G.: Chronic urticaria. Acta Dermato-Venereologica (Stockholm) 49: 404–416 (1969).

    Google Scholar 

  • Moore-Robinson, M. and Warin, R.P.: Effect of salicylates in urticaria. British Medical Journal 4: 262–266 (1967).

    PubMed  CAS  Google Scholar 

  • Morales, M.C.; Basomba, A.; Pelaez, A.; Villalmanzo, I.G. and Campos, A.: Challenge tests with tartrazine in patients with asthma associated with intolerance to analgesics (ASA-tried). Clinical Allergy 15: 55–59 (1985).

    PubMed  CAS  Google Scholar 

  • Nemoto, T.; Aoki, H.; Ike, A.; Yamada, K.; Kondo, T.; Kobayashi, S. and Inagawa, T.: Serum prostaglandin levels in asthmatic patients. Journal of Allergy and Clinical Immunology 57: 89–94 (1976).

    PubMed  CAS  Google Scholar 

  • Nigam, S.; Kunkel, G.; Herold, D.; Baumer, F.E. and Jusuf, L.: Nasal polyps and their content of arachidonic acid. New England and Regional Allergy Proceedings 7: 109–112 (1986)

    PubMed  CAS  Google Scholar 

  • Nizankowska, E.; Czerniawska-Mysik, G. and Szczeklik, A.: Lack of effect of prostacyclin in aspirin-induced asthma. European Journal of Respiratory Diseases 69: 363–368, 1986.

    PubMed  CAS  Google Scholar 

  • Noid, H.E.; Schulze, T.W. and Winkelmann, R.K.: Diet plan for patients with salicylate-induced urticaria. Archives of Dermatology 109: 666–670 (1974).

    Google Scholar 

  • O’Brien, W.M. and Bagby, G.F.: Rare adverse reactions to non-steroidal antiinflammatory drugs. Journal of Rheumatology 12: 13–20, 347–353 (1985).

    PubMed  Google Scholar 

  • Oldstone, M.B.A.; Rodriguez, M.; Daughaday, W.H. and Lampert, P.W.: Viral perturbation of endocrine function: Disordered cell function leads to disturbed homeostasis and disease. Nature 307: 278–281 (1984).

    PubMed  CAS  Google Scholar 

  • Ortolani, C.; Capsoni, C.; Restuccia, M.; Pastorello, E.; Riboldi, P.; Zocchi, M. and Zanussi, C.: Neutrophil chemotactic factor of anaphylaxis release in aspirin-induced asthma. Clinical Allergy 14: 443–452 (1984).

    PubMed  CAS  Google Scholar 

  • Patrono, C.; Ciabattoni, G.; Venuti, A.; Pugliese, F.; Schiavino, D. and Patriarca, G.: Aspirin intolerance: Unaltered susceptibility of platelet cyclooxygenase to inhibition by aspirin in vitro. Journal of Allergy and Clinical Immunology 62: 271–275 (1978).

    PubMed  CAS  Google Scholar 

  • Pleskow, W.W.; Stevenson, D.D.; Simon, R.A.; Mathison, D.A.; Schatz, M. and Zeiger, R.S.: Aspirin-sensitive rhino-sinusitis/asthma: Spectrum of adverse reactions to aspirin. Journal of Allergy and Clinical Immunology 71: 574–580 (1983).

    PubMed  CAS  Google Scholar 

  • Pleskow, W.W.; Lumry, W. and Simon, R.: Zomepirac sodium (Zomax) hypersensitivity in aspirin-sensitive asthmatics. American Review of Respiratory Diseases 130: 1170–1173 (1984).

    CAS  Google Scholar 

  • Przybilla, B.; Ring, J. and Burg, G.: Anaphylaxie nach kaffeegenuss, chronische Urtikaria und Analgetika-Idiosynkrasie. Der Hautarzt 34: 73–76 (1983).

    CAS  Google Scholar 

  • Rasmussen, J.: Toxic epidermal necrolysis. Medical Clinics of North America 64: 901–920 (1980).

    PubMed  CAS  Google Scholar 

  • Roberts, L.J.; Sweetman, B.J.; Lewis, R.A.; Folarin, V.F.; Austin, K.F. and Oates, J.A.: Increased production of prostaglandin D2 in patients with systemic mastocytosis. New England Journal of Medicine 303: 1400–1403 (1980).

    PubMed  Google Scholar 

  • Roberts, L.J. II, and Oates, J.A.: Quantification of thromboxane and PGD2 metabolites in biological fluids. Prostaglandins 27: 352–354 (1984).

    Google Scholar 

  • Roujeau, J.C.; Revuz, J.; Touraine, R.; Albengres, E. and Tillement, J.P.: Syndrome du Lyell au cours d’un traitement par un nouvel anti-inflammatoire. Nouvelle Presse Medicale 10: 3407–3408 (1981).

    PubMed  CAS  Google Scholar 

  • Rudzki, E.: Chronic urticaria due to aspirin and food additives (in Polish). Przeglad Dermatologiczny 64: 163–166 (1977).

    PubMed  CAS  Google Scholar 

  • Salmon, J.A.; Higgs, G.A.; Tilling, L.; Moncada, S. and Vane, J.R.: Mode of action of benoxaprofen. Lancet 1: 848 (1984).

    PubMed  CAS  Google Scholar 

  • Samter, M. and Beers, R.F.Jr: Intolerance to aspirin: Clinical studies and consideration of its pathogenesis. Annals of Internal Medicine 68: 975–983 (1968).

    PubMed  CAS  Google Scholar 

  • Schiavino, D.; Venuti, A.; Romano, A.; Fais, G.; de Salvo, V. and Patriarca, G.: In vivo and in vitro diagnosis of aspirin intolerance. Acta Medica Romano 19: 187–191 (1981).

    Google Scholar 

  • Schlumberger, H.D.: Drug-induced pseudo-allergic syndrome as exemplified by acetylsalicylic acid intolerance; in Dukor et al. (Eds) Cell Mediated Reactions, Miscellaneous Topics: PAR vol. 3: Pseudo-Allergic Reactions. Involvement of Drugs and Chemicals, pp. 125–203 (Karger, Basel 1982).

    Google Scholar 

  • Schmitz-Schumann, M.; Schaub, E. and Virchow, C.: Inhalative Provokation mit Lysin-Azetylsalizylsäure bei Analgetika-Asthma-Syndrom. Praxis und Klinik der Pneumologie 36: 17–21 (1982).

    PubMed  CAS  Google Scholar 

  • Schuhl, J.F. and Pereyra, J.G.: Oral acetylsalicylic acid (aspirin) in asthmatic children. Clinical Allergy 9: 83–88 (1979).

    PubMed  CAS  Google Scholar 

  • Schulz, K.H.: Cutaneous manifestations of drug allergy; in de Weck and Bundgaard (Eds) Allergic reactions to drugs. Handbook of Experimental Pharmacology, vol. 63 (Springer Verlag, Berlin-Heidelberg-New York-Tokyo 1983).

    Google Scholar 

  • Serhan, C.N.; Hamberg, M. and Samuelsson, B.: Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proceedings of the National Academy of Sciences USA 81: 5335–5340 (1984).

    CAS  Google Scholar 

  • Settipane, G.A.: Aspirin and allergic diseases: A review. American Journal of Medicine 74: 102–107 (1983).

    PubMed  CAS  Google Scholar 

  • Settipane, G.A. and Paddupakkam, R.K.: Aspirin intolerance. III. Subtype, familial occurrence, and cross-reactivity with tartrazine. Journal of Allergy and Clinical Immunology 56: 215–221 (1975).

    PubMed  CAS  Google Scholar 

  • Settipane, G.A.; Chafee, F.H.; Postman, I.M.; Levine, M.J.; Saker, J.H.; Barrick, R.H.; Nicholas, S.; Schwarz, H.J.; Honsinger, R.W. and Klein, D.E.: Significance of tartrazine sensitivity in chronic urticaria of unknown aetiology. Journal of Allergy and Clinical Immunology 57: 541–546 (1976).

    PubMed  CAS  Google Scholar 

  • Settipane, G.A. and Chafee, F.H.: Nasal polyps in asthma and rhinitis. Journal of Allergy and Clinical Immunology 59: 17–21 (1977).

    PubMed  CAS  Google Scholar 

  • Simon, R.A.; Pleskow, W.W.; Stevenson, D.D. and Mathison, D.A.: Aspirin sensitivity: Description of aspirin (ASA) respiratory sensitivity; in Kornblat and Wedner (Eds) Allergy: Theory and Practice, pp.435–452 (Grune and Stratton Inc., New York 1984).

    Google Scholar 

  • Slepian, I.K.; Mathews, K.P. and McLean, J.A.: Aspirin-sensitive asthma. Chest 87: 386–391 (1985).

    PubMed  CAS  Google Scholar 

  • Sonnenblick, M. and Abraham, A.S.: Ibuprofen hypersensitivity in systemic lupus erythematosus. British Medical Journal 1: 618–619 (1978).

    Google Scholar 

  • Spector, S.L.; Wangaard, C.H. and Fair, R.S.: Aspirin and concomitant idiosyncracies in adult asthmatic patients. Journal of Allergy and Clinical Immunology 64: 500–506 (1979).

    PubMed  CAS  Google Scholar 

  • Spector, S.L.; Morris, H.G. and Seiner, J.C.: Clinical responses and serum prostaglandin levels in aspirin idiosyncrasy. Effect of aspirin and a new nonsteroidal anti-inflammatory agent. Chest 80: 676–681 (1981).

    PubMed  CAS  Google Scholar 

  • Stern, S. and Bigby M.: An expanded profile of cutaneous reactions to non-steroidal anti-inflammatory drugs. Journal of the American Medical Association 252: 1433–1437 (1984).

    PubMed  CAS  Google Scholar 

  • Stevenson, D.D. and Mathison, D.A.: Aeroallergen inhalation challenge in aspirin-intolerant patients. Journal of Allergy and Clinical Immunology 55: 127–132 (1975).

    Google Scholar 

  • Stevenson, D.D.; Arroyave, C.M.; Bhat, K.N. and Tan, E.M.: Oral aspirin challenge in asthmatic patients: A study of plasma histamine. Clinical Allergy 6: 493–506 (1976).

    PubMed  CAS  Google Scholar 

  • Stevenson, D.D.; Pleskow, W.W.; Simon, R.A.; Mathison, D.A.; Lumry, W.R.; Schatz, M. and Zeiger, R.: Aspirin-sensitive rhinosinusitis asthma: A double-blind cross-over study of treatment with aspirin. Journal of Allergy and Clinical Immunology 73: 500–507 (1984).

    PubMed  CAS  Google Scholar 

  • Szczeklik, A.; Gryglewski, R.J. and Czerniawska-Mysik, G.: Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. British Medical Journal 1: 67–69 (1975).

    PubMed  CAS  Google Scholar 

  • Szczeklik, A. and Czerniawska-Mysik, G.: Prostaglandins and aspirin-induced asthma. Lancet 1: 488 (1976).

    Google Scholar 

  • Szczeklik, A.; Gryglewski, R.J. and Czerniawska-Mysik, G.: Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis. Journal of Allergy and Clinical Immunology 60: 276–284 (1977a).

    PubMed  CAS  Google Scholar 

  • Szczeklik, A.; Gryglewski, R.J.; Olszewski, E.; Dembinska-Kiec, A. and Czerniawska-Mysik, G.: Aspirin-sensitive asthma: The effect of aspirin on the release of prostaglandins from nasal polyps. Pharmacological Research Communications 9: 415–425 (1977b).

    PubMed  CAS  Google Scholar 

  • Szczeklik, A.; Nizankowska, E. and Nizankowski, R.: Bronchial reactivity to prostaglandins F2α, E2 and histamine in different types of asthma. Respiration 34: 323–331 (1977c).

    PubMed  CAS  Google Scholar 

  • Szczeklik, A. and Serwońska, M.: Inhibition of idiosyncratic reactions to aspirin in asthmatic patients by clemastine. Thorax 34: 654–657 (1979).

    PubMed  CAS  Google Scholar 

  • Szczeklik, A.; Czerniawska-Mysik, O.; Serwońska, M. and Kukliński, P.: Inhibition by ketotifen of idiosyncratic reactions to aspirin. Allergy 35: 421–424 (1980).

    PubMed  CAS  Google Scholar 

  • Szczeklik, A. and Gryglewski, R.J.: Asthma and anti-inflammatory drugs. Mechanisms and clinical patterns. Drugs 25: 533–543 (1983).

    PubMed  CAS  Google Scholar 

  • Szczeklik, A. and Nizankowska, E.: Asthma improved by aspirin-like drugs. British Journal of Diseases of the Chest 77: 153–158 (1983)

    PubMed  CAS  Google Scholar 

  • Szczeklik, A.; Czerniawska-Mysik, G. and Nizankowska, E.: Allergische und pseudoallergische Reaktionen auf Pyrazolonprä-parate; in Brune et al. (Eds) 100 Jahre Pyrazolone, pp. 247–252 (Urban & Schwarzenberg, München 1985a).

    Google Scholar 

  • Szczeklik, A.; Nizankowska, E.; Czerniawska-Mysik, G. and Sek, S.: Hydrocortisone and airflow impairment in aspirin-induced asthma. Journal of Allergy and Clinical Immunology 76: 530–536 (1985b).

    PubMed  CAS  Google Scholar 

  • Szmidt, M.; Grzelewska-Rzymowska, I.; Rozniecki, J.; Kowalski, M. and Rychlicka, I.: Histaminemia after aspirin challenge in aspirin-sensitive asthmatics. Agents and Actions 11: 105–107 (1981).

    PubMed  CAS  Google Scholar 

  • Tan, Y. and Collin-Williams, C.: Aspirin-induced asthma in children. Annals of Allergy 48: 1–5 (1982).

    PubMed  CAS  Google Scholar 

  • Turk, J.; Oates, J.A. and Roberts, L.J.: Intervention with epinephrine in hypotension associated with mastocytosis. Journal of Allergy and Clinical Immunology 71: 189–194 (1983).

    PubMed  CAS  Google Scholar 

  • Van Arsdel, P.P.: Aspirin idiosyncrasy and tolerance. Journal of Allergy and Clinical Immunology 73: 431–434 (1984).

    Google Scholar 

  • Vane, J.R.: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 231: 232–234 (1971).

    CAS  Google Scholar 

  • Vanecek, čJ.: Antipyretic analgesics; in Dukes (Ed.) Side Effects of Drugs: Annual 7, pp. 93–103 (Excerpta Medica, Amsterdam 1983).

    Google Scholar 

  • Virchow, C.: Analgetika-Intoleranz bei Asthmatikern (Analgetika-Asthma-Syndrom). Praxis und Klinik der Pneumologic 30: 642–692 (1976).

    Google Scholar 

  • Voigtländer, V.; Hänsch, G. and Rother, U.: Acetylsalicylic acid intolerance: A possible role of complement. International Archives of Allergy and Applicd Immunology 66(Suppl. 1): 154–155 (1981).

    Google Scholar 

  • Waldenström, J.G.: Urticaria pigmentosa and acetylsalicylic acid intolerance; in Dukor et al. (Eds) Pseudoallergic Reactions, vol. 1, pp. 204–218 (Karger, Basel 1980).

    Google Scholar 

  • Warin, R.P.: The effect of aspirin in chronic urticaria. British Journal of Dermatology 72: 350–351 (1960).

    PubMed  CAS  Google Scholar 

  • Warin, R.P. and Smith, J.P.: Role of tartrazine in chronic urticaria. British Medical Journal 284: 1443–1444 (1982a).

    PubMed  CAS  Google Scholar 

  • Warin, R.P. and Smith, R.J.: Chronic urticaria: Investigations with patch and challenge tests. Contact Dermatitis 8: 117–121 (1982b).

    PubMed  CAS  Google Scholar 

  • Weber, R.W.; Hoffman, M.; Raine, D.A. and Nelson, H.S.: Incidence of bronchoconstriction due to aspirin, azo dyes, non-azo dyes and preservatives in a population of perennial asthmatics. Journal of Allergy and Clinical Immunology 64: 32–37 (1979).

    PubMed  CAS  Google Scholar 

  • De Weck, A.L.: Immunological effects of aspirin anhydride, a contaminant of commercial acetylsalicylic acid preparations. International Archives of Allergy and Applicd Immunology 41: 393–398 (1971).

    Google Scholar 

  • Wolfe, R.N.; Hui, K.K.; Conolly, M.E.; Tashkin, D.P. and Fisher, H.K.: A study of beta-adrenergic and prostaglandin receptors in paticnts with aspirin-induced bronchospasm. Journal of Allergy and Clinical Immunology 69: 46–50 (1982).

    PubMed  CAS  Google Scholar 

  • Wüthrich, B. and Fabro, L.: Azetylsalicylsäure und Lebensmittel additiva-Intoleranz bei Urtikaria, Asthma bronchiale und chronischer Rhinopathic. Schweizerische Medizinische Wochenschrift 111: 1445–1449 (1981).

    PubMed  Google Scholar 

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  1. Department of Medicine, Copernicus Academy of Medicine, Skawinska 8, 31-006, Krakow, Poland

    Andrew Szczeklik

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Szczeklik, A. Analgesics, Allergy and Asthma. Drugs 32 (Suppl 4), 148–163 (1986). https://doi.org/10.2165/00003495-198600324-00011

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