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Disposition of Drugs in Block Copolymer Micelle Delivery Systems

From Discovery to Recovery

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Abstract

Since their discovery in the early 1980s, polymeric micelles have been the subject of several studies as delivery systems that can potentially improve the therapeutic performance and modify the toxicity profile of encapsulated drugs by changing their pharmacokinetic characteristics. The efforts in this area have led in recent years to the advancement of several polymeric micellar formulations to clinical trials, some of which have shown promise in changing the biodistribution of the incorporated drug after intravenous administration as a means of tumour-targeted drug delivery. Recently, the possible benefit of polymeric micellar delivery in enhancing the absorption and bioavailability of incorporated drugs from alternative routes of drug administration has attracted interest. This article provides an overview of the effect of polymeric micellar delivery on absorption, distribution, metabolism and excretion of incorporated therapeutic agents. It also aims to assess the current information on the performance of polymeric micellar delivery systems in modifying the pharmacokinetics/pharmacodynamics of the incorporated drugs in clinical trials, and to re-examine the important structural factors required for successful design of polymeric micellar delivery systems capable of inducing favourable changes in the pharmacokinetics of the encapsulated drug.

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Notes

  1. The use of trade names is for product identification purposes only and does not imply endorsement.

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Acknowledgements

The authors would like to acknowledge funding from the Natural Sciences and Engineering Council of Canada (NSERC) and the Canadian Institutes of Health Research (CIHR). The authors have no conflicts of interest that are directly relevant to the content of this review.

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  1. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, T6G 2N8, Canada

    Hamidreza Montazeri Aliabadi, Mostafa Shahin, Dion R. Brocks &  Afsaneh Lavasanifar

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  1. Hamidreza Montazeri Aliabadi
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  2. Mostafa Shahin
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  3. Dion R. Brocks
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  4. Afsaneh Lavasanifar
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Correspondence to Afsaneh Lavasanifar.

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Aliabadi, H.M., Shahin, M., Brocks, D.R. et al. Disposition of Drugs in Block Copolymer Micelle Delivery Systems. Clin Pharmacokinet 47, 619–634 (2008). https://doi.org/10.2165/00003088-200847100-00001

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