GLYCYRRHETIC ACID INHIBITS TUMOR-PROMOTING ACTIVITY OF TELEOCIDIN AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE IN TWO-STAGE MOUSE SKIN CARCINOGENESIS

Hoyoku NISHINO; Kuninori YOSHIOKA; Akio IWASHIMA; Haruo TAKIZAWA; Sumie KONISHI; Hitoshi OKAMOTO; Hidetoshi OKABE; Shoji SHIBATA; Hirota FUJIKI; Takashi SUGIMURA

doi:10.20772/cancersci1985.77.1_33

Hoyoku NISHINO, Kuninori YOSHIOKA, Akio IWASHIMA, Haruo TAKIZAWA, Sumie KONISHI, Hitoshi OKAMOTO, Hidetoshi OKABE, Shoji SHIBATA, Hirota FUJIKI, Takashi SUGIMURA

Author information

Hoyoku NISHINO
Department of Biochemistry, Kyoto Prefectural University of Medicine
Kuninori YOSHIOKA
Department of Biochemistry, Kyoto Prefectural University of Medicine
Akio IWASHIMA
Department of Biochemistry, Kyoto Prefectural University of Medicine
Haruo TAKIZAWA
Biological Research Center, Central Research Institute, Japan Tobacco Inc.
Sumie KONISHI
Biological Research Center, Central Research Institute, Japan Tobacco Inc.
Hitoshi OKAMOTO
Biological Research Center, Central Research Institute, Japan Tobacco Inc.
Hidetoshi OKABE
Department of Laboratory Medicine, Shiga University of Medical Science
Shoji SHIBATA
Meiji College of Pharmacy
Hirota FUJIKI
National Cancer Center Research Institute
Takashi SUGIMURA
National Cancer Center Research Institute

Keywords: Glycyrrhetic acid, Anti-tumor promoting activity

JOURNAL FREE ACCESS

1986 Volume 77 Issue 1 Pages 33-38

DOI https://doi.org/10.20772/cancersci1985.77.1_33

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Abstract

Glycyrrhetic acid suppressed tumor promoter-induced effects in vitro, such as stimulation of ³²Pi-incorporation into phospholipids of cultured cells and down-regulation of the epidermal growth factor receptor. Glycyrrhetic acid inhibited the promoting activity of both 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin on skin tumor formation in mice initiated with 7, 12-dimethylbenz[a]anthracene (DMBA). The percentage of tumor-bearing mice in the group treated with DMBA plus teleocidin was 88% at week 18, whereas that in the group treated with DMBA plus teleocidin and glycyrrhetic acid (10μmol/painting) was 6%. Similarly, the percentage of tumor-bearing mice of the group treated with DMBA plus TPA was 97% at week 20, whereas that of the group treated with DMBA plus TPA and glycyrrhetic acid was 40%. Therefore, glycyrrhetic acid was proved to inhibit the activity of two different tumor promoters, teleocidin and TPA, in mouse skin.

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