Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis

Long Tian; Rujun Zeng; Xin Wang; Cheng Shen; Yutian Lai; Mingming Wang; Guowei Che

doi:10.18632/oncotarget.17436

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Meta-Analysis:

Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis

Long Tian, Rujun Zeng, Xin Wang, Cheng Shen, Yutian Lai, Mingming Wang and Guowei Che _

PDF | HTML | How to cite

Oncotarget. 2017; 8:46425-46435. https://doi.org/10.18632/oncotarget.17436

Metrics: PDF 1477 views | HTML 2947 views | ?

Abstract

Long Tian1,*, Rujun Zeng2,*, Xin Wang1,*, Cheng Shen1, Yutian Lai1, Mingming Wang1 and Guowei Che1

1Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China

2Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China

*These authors have contributed equally to this work

Correspondence to:

Guowei Che, email: [email protected]

Keywords: soluble mesothelin, malignant pleural mesothelioma, prognosis, meta-analysis

Abbreviations: MPM: malignant pleural mesothelioma; CI: confidence interval; HR: hazard ratio

Received: November 30, 2016 Accepted: April 10, 2017 Published: April 26, 2017

ABSTRACT

Background: Soluble mesothelin is beneficial to detect the progression and the treatment response of malignant pleural mesothelioma. However, the prognostic value of soluble mesothelin in malignant pleural mesothelioma remains unclear.

Methods: Hazard ratio with 95% CI was used to evaluate the prognostic value of soluble mesothelin and the effect of clinicopathological characteristics on the survival of malignant pleural mesothelioma.

Results: Eight eligible studies involving 579 patients were selected for this meta-analysis. The results showed that soluble mesothelin level was significantly correlated with the survival of malignant pleural mesothelioma (pooled HR: 1.958, 95%CI: 1.531-2.504, p = 0.000; heterogeneity test: I² = 1.1%, p = 0.421). In addition, the survival of malignant pleural mesothelioma was significantly correlated with some clinicopathological characteristics such as tumor histology (HR = 3.214, 95% CI = 2.071-4.988, p = 0.000; heterogeneity test: I² = 0.0%, p = 0.623) and tumor stage (HR = 2.007; 95% CI = 1.477-2.727; p = 0.000; heterogeneity test: I² = 0.0%, p = 0.966).

Conclusions: The survival of malignant pleural mesothelioma is significantly correlated with tumor histology and tumor stage. Furthermore, high soluble mesothelin level may lead to a poor prognosis for malignant pleural mesothelioma patients.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 17436

Publication Alerts

Meta-Analysis:

Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis

Abstract