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Non-distorted visible light-absorbing thiol-PEGylated gold-coated superparamagnetic iron oxide nanoparticles–porphyrin conjugates and their inhibitory effects against nosocomial pathogens

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Abstract

A low-cost synthesis approach was developed for the fabrication of four symmetric meso-substituted water-soluble thiolated polyethylene glycol gold-coated superparamagnetic iron oxide nanoparticles–porphyrin (p-hydroxyphenyl [THPP], 3,5-dimethoxyphenyl [TdMPP], 3-pyr-idyl[T-3-PyP], and 1-methylpyridinium-3-yl[T3-Py+P4I-]) conjugates to achieve materials with enhanced absorption and therapeutic properties. After evaluation of their antibacterial inhibition characteristics against four nocosomial pathogens (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecalis), THPP and TdMPP conjugates showed some remarkable minimum inhibitory concentration values of 0.104 and 0.625 mg/mL against E. coli and E. faecalis, respectively, making these materials to be alternative agents for the inhibition of these pathogens in the environmental and clinical fields.

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ACKNOWLEDGMENTS

The authors are grateful to the National Research Foundation (NRF), South Africa, under the Nanotechnology Flagship Programme (Grant no. 97983), and the Collaborative Postgraduate Training Grant (Grant no. 105262) for financial support. B.M.A.-T. appreciates Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria, for granting him study leave to accomplish this work.

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Authors and Affiliations

  1. Department of Chemical Sciences (formerly Applied Chemistry), University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa

    Bamidele M. Amos-Tautua, Olayemi J. Fakayode & Oluwatobi S. Oluwafemi

  2. Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa

    Bamidele M. Amos-Tautua, Olayemi J. Fakayode & Oluwatobi S. Oluwafemi

  3. Department of Pharmacy and Pharmacology, University of the Witwatersrand, Parktown 2193, Johannesburg, South Africa

    Sandy van Vuuren

  4. Department of Chemistry, University of KwaZulu-Natal, Private Bag X 54001, Durban, 4000, South Africa

    Sandile P. Songca

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  1. Bamidele M. Amos-Tautua
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  2. Olayemi J. Fakayode
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Correspondence to Oluwatobi S. Oluwafemi.

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The supplementary material for this article can be found at https://doi.org/10.1557/mrc.2019.141.

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Amos-Tautua, B.M., Fakayode, O.J., van Vuuren, S. et al. Non-distorted visible light-absorbing thiol-PEGylated gold-coated superparamagnetic iron oxide nanoparticles–porphyrin conjugates and their inhibitory effects against nosocomial pathogens. MRS Communications 9, 1335–1342 (2019). https://doi.org/10.1557/mrc.2019.141

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