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Biomimetic gelatine coating for less-corrosive and surface bioactive Mg-9Al-1Zn alloys

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Abstract

Magnesium (Mg)-based alloys have been emerging as innovative orthopedic materials due to their light weight and excellent biocompatibility. However, their too rapid degradation and subsequent loss of mechanical integrity before the bone tissue regeneration limits their applications. The presented study introduces in situ cross-linked gelatine (GEL) as a biomimetic coating onto Mg-9Al-1Zn-based alloys by carbodiimide chemistry and dip-coating. The bulk and surface morphology, chemistry, and bioactivity, as well as the corrosion behavior of uncoated and coated alloys were investigated in simulated body fluid (SBF) solution via in vitro testing and using various analytical techniques. The results revealed that the GEL coating mitigates the corrosion (from ∼2.08 to ∼1.19 mm/year) by forming a protective interface layer between the alloy surface and SBF solution, generating a bio-safer alkaline pH environment (pH ≈ 8.3), which minimizes the material resorption. GEL presence also stimulates the mineralization with calcium phosphate compounds, being patterned by its orientation and random coil conformation.

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ACKNOWLEDGMENT

This work was supported financially by the Erasmus Mundus Grant no. EMA2-2013-2540/001-001-EM-EUPHRATES.

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Authors and Affiliations

  1. Faculty of Mechanical Engineering, University of Maribor, Maribor, 2000, Slovenia

    Hanuma Reddy Tiyyagura, Selestina Gorgieva & Vanja Kokol

  2. NIT Warangal, National Institute of Technology, Telangana, 506004, India

    Hanuma Reddy Tiyyagura & Mantravadi Krishna Mohan

  3. Faculty of Chemistry and Chemical Engineering, University of Maribor, Maribor, 2000, Slovenia

    Regina Fuchs-Godec

  4. Magnesium Technology Innovation Centre, School of Materials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea

    Srinivasan Arthanari

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  1. Hanuma Reddy Tiyyagura
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  2. Regina Fuchs-Godec
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  3. Selestina Gorgieva
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  5. Mantravadi Krishna Mohan
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Correspondence to Mantravadi Krishna Mohan or Vanja Kokol.

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Tiyyagura, H.R., Fuchs-Godec, R., Gorgieva, S. et al. Biomimetic gelatine coating for less-corrosive and surface bioactive Mg-9Al-1Zn alloys. Journal of Materials Research 33, 1449–1462 (2018). https://doi.org/10.1557/jmr.2018.65

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