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A targeted drug delivery system based on carbon nanotubes loaded with lobaplatin toward liver cancer cells

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Abstract

To eliminate the toxic effect of chemotherapy drug of lobaplatin (LBP) on body tissue in liver cancer therapy, this work prepared a nanodrug carrier based on polyethylene glycol-modified carbon nanotubes (PEG–CNTs) and then constructed a targeted drug delivery system (LBP–PEG–CNTs) by loading LBP on PEG–CNTs. Fluorescein isothiocyanate (FITC) was used to label PEG–CNTs to observe the cellular uptake of PEG–CNTs. In addition, the inhibitions of LBP–PEG–CNTs on HepG2 cells were investigated. The results show that the FITC-labeled PEG–CNTs have good cell penetrability; meanwhile, LBP–PEG–CNTs have good stability, pH-controlled release property, and high inhibition rate on HepG2 cells. To be specific, 80% of LBP is released under physiological conditions of liver cancer cells at pH 5.0, and LBP–PEG–CNTs show a high inhibition rate of 77.86% on HepG2 cells, demonstrating that they have targeted, pH-controlled release and inhibition properties on HepG2 cells.

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ACKNOWLEDGMENTS

This study was financially supported by Shanxi Provincial Key Research and Development Program (201703D321015-1) and the Shanxi Provincial Key Innovative Research Team in Science and Technology (2015013002-10 and 201605D131045-10).

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Authors and Affiliations

  1. Interventional Treatment Department, Second Hospital of Shanxi Medical University, Taiyuan, 030001, China

    Shiping Yu, Qiang Li & Jinglei Du

  2. Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan, 030024, China

    Shiping Yu, Junli Wang, Lin Chen, Yongzhen Yang & Xuguang Liu

  3. Research Center on Advanced Materials Science and Technology, Taiyuan University of Technology, Taiyuan, 030024, China

    Junli Wang, Lin Chen & Yongzhen Yang

  4. Ophthalmology Department, Shanxi Dayi Hospital, Taiyuan, 030032, China

    Yuduan Gao

  5. Urology Department, Shanxi Dayi Hospital, Taiyuan, 030032, China

    Li Zhang

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  1. Shiping Yu
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  2. Qiang Li
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  3. Junli Wang
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  7. Lin Chen
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  8. Yongzhen Yang
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  9. Xuguang Liu
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Correspondence to Shiping Yu or Yongzhen Yang.

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Yu, S., Li, Q., Wang, J. et al. A targeted drug delivery system based on carbon nanotubes loaded with lobaplatin toward liver cancer cells. Journal of Materials Research 33, 2565–2575 (2018). https://doi.org/10.1557/jmr.2018.197

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  • DOI: https://doi.org/10.1557/jmr.2018.197

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