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Biocompatibility and anticancer activity of L-phenyl alanine-coated iron oxide magnetic nanoparticles as potential chrysin delivery system

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An Erratum to this article was published on 01 December 2019

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Abstract

In this project, we described the production of chrysin-loaded L-phenyl alanine (Phe)-coated iron oxide magnetic nanoparticles (chrysin@Phe@IOMNs). chrysin@Phe@IOMNs were characterized by X-ray diffraction, thermogravimetric analysis, fourier transform infrared spectroscopy, vibrating sample magnetometer, and transmission electron microscopy techniques. Next, hemocompatibility and biocompatibility of Phe-coated IOMNs were determined by hemolysis and MTT assays on HFF-2 and HEK-293 cell lines, respectively. Finally, the anticancer activity of chrysin@Phe@IOMNs was examined on MCF-7 cell line. The outcomes direct that as-prepared nanocarriers are nontoxic and biocompatible and also chrysin@Phe@IOMNs are appropriate for chrysin delivery and other hydrophobic therapeutic agents.

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ACKNOWLEDGMENT

This work has been supported financially by Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran (Grant No: A-12-430-26).

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Authors and Affiliations

  1. Student Research Center, Zanjan University of Medical Sciences, Zanjan, 009824, Iran

    Hamed Nosrati

  2. Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 009824, Iran

    Hamed Nosrati & Hossein Danafar

  3. Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, 009824, Iran

    Elham Javani, Marziyeh Salehiabar & Hossein Danafar

  4. Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, 009824, Iran

    Hamidreza Kheiri Manjili

  5. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 009841, Iran

    Soodabeh Davaran

Authors
  1. Hamed Nosrati
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  2. Elham Javani
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  3. Marziyeh Salehiabar
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  4. Hamidreza Kheiri Manjili
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  6. Hossein Danafar
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Correspondence to Hossein Danafar.

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Nosrati, H., Javani, E., Salehiabar, M. et al. Biocompatibility and anticancer activity of L-phenyl alanine-coated iron oxide magnetic nanoparticles as potential chrysin delivery system. Journal of Materials Research 33, 1602–1611 (2018). https://doi.org/10.1557/jmr.2018.148

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