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Licensed Unlicensed Requires Authentication Published by De Gruyter January 18, 2017

Role of glial cell line-derived neurotrophic factor in the pathogenesis and treatment of mood disorders

  • Anton S. Tsybko

    Anton S. Tsybko graduated from Altay State University in 2010. In 2013, he defended his PhD thesis and became a researcher at the Department of Behavioral Neurogenomics at the Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. Now, he investigates the role of the interaction of neurotrophic factors and brain neurotransmitter systems in the regulation of brain function and different kinds of behavior. He is a member of the International Behavioral and Neural Genetics Society, Federation of European Neuroscience Societies, and Canadian Association for Neuroscience. He is the author and coauthor of more than 30 papers in Russian and international peer-reviewed journals.

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    , Tatiana V. Ilchibaeva

    Tatiana V. Ilchibaeva defended her Master’s thesis at Altay State University in 2013. She is currently a PhD student at the Department of Behavioral Neurogenomics at the Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. In 2015, she was awarded by the Stipend of the Government of the Russian Federation for Young Investigators. Her interests include the involvement of neurotrophic factors in the regulation of different types of normal and pathological behavior. She is a member of the International Behavioral and Neural Genetics Society, Federation of European Neuroscience Societies, Canadian Association for Neuroscience. She is the author and coauthor of 17 papers in peer-reviewed journals.

    and Nina K. Popova

    Nina K. Popova, DSci, Professor, Honored Scientist of Russia, Chief Researcher of the Laboratory of Behavioral Neurogenomics at the Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. Until 2014, for more than 40 years, she was the head of the Laboratory of Behavioral Neurogenomics since its foundation in 1972. She has authored more than 300 articles published in Russian and international neuroscience journals. She is a member of the Russian Physiological Society, Vavilov Society of Geneticists, International Behavioral and Neural Genetics Society, and Serotonin Club. Her main interest is the role of brain neurotransmitters (mainly serotonin) in genetically defined normal and pathological behavior (aggression, catalepsy, anxiety, and depression) in both animals and humans.

Abstract

Glial cell line-derived neurotrophic factor (GDNF) is widely recognized as a survival factor for dopaminergic neurons, but GDNF has also been shown to promote development, differentiation, and protection of other central nervous system neurons and was thought to play an important role in various neuropsychiatric disorders. Severe mood disorders, such as primarily major depressive disorder and bipolar affective disorder, attract particular attention. These psychopathologies are characterized by structural alterations accompanied by the dysregulation of neuroprotective and neurotrophic signaling mechanisms required for the maturation, growth, and survival of neurons and glia. The main objective of this review is to summarize the recent findings and evaluate the potential role of GDNF in the pathogenesis and treatment of mood disorders. Specifically, it describes (1) the implication of GDNF in the mechanism of depression and in the effect of antidepressant drugs and mood stabilizers and (2) the interrelation between GDNF and brain neurotransmitters, playing a key role in the pathogenesis of depression. This review provides converging lines of evidence that (1) brain GDNF contributes to the mechanism underlying depressive disorders and the effect of antidepressants and mood stabilizers and (2) there is a cross-talk between GDNF and neurotransmitters representing a feedback system: GDNF-neurotransmitters and neurotransmitters-GDNF.

About the authors

Anton S. Tsybko

Anton S. Tsybko graduated from Altay State University in 2010. In 2013, he defended his PhD thesis and became a researcher at the Department of Behavioral Neurogenomics at the Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. Now, he investigates the role of the interaction of neurotrophic factors and brain neurotransmitter systems in the regulation of brain function and different kinds of behavior. He is a member of the International Behavioral and Neural Genetics Society, Federation of European Neuroscience Societies, and Canadian Association for Neuroscience. He is the author and coauthor of more than 30 papers in Russian and international peer-reviewed journals.

Tatiana V. Ilchibaeva

Tatiana V. Ilchibaeva defended her Master’s thesis at Altay State University in 2013. She is currently a PhD student at the Department of Behavioral Neurogenomics at the Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. In 2015, she was awarded by the Stipend of the Government of the Russian Federation for Young Investigators. Her interests include the involvement of neurotrophic factors in the regulation of different types of normal and pathological behavior. She is a member of the International Behavioral and Neural Genetics Society, Federation of European Neuroscience Societies, Canadian Association for Neuroscience. She is the author and coauthor of 17 papers in peer-reviewed journals.

Nina K. Popova

Nina K. Popova, DSci, Professor, Honored Scientist of Russia, Chief Researcher of the Laboratory of Behavioral Neurogenomics at the Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. Until 2014, for more than 40 years, she was the head of the Laboratory of Behavioral Neurogenomics since its foundation in 1972. She has authored more than 300 articles published in Russian and international neuroscience journals. She is a member of the Russian Physiological Society, Vavilov Society of Geneticists, International Behavioral and Neural Genetics Society, and Serotonin Club. Her main interest is the role of brain neurotransmitters (mainly serotonin) in genetically defined normal and pathological behavior (aggression, catalepsy, anxiety, and depression) in both animals and humans.

Acknowledgments

This work was supported by the Russian Scientific Foundation (grant number 14-25-00038).

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Received: 2016-9-26
Accepted: 2016-11-3
Published Online: 2017-1-18
Published in Print: 2017-4-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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