Abstract
C15H16N2O2, monoclinic, P21/c (no. 14), a = 10.8334(5) Å, b = 11.7225(5) Å, c = 12.6861(6) Å, β = 123.417(5)°, V = 1344.73(1) Å3, Z = 4, Rgt(F) = 0.0607 , wRref(F2) = 0.1662, T = 297 K.
The asymmetric unit of the title crystal structure is shown in the figure. Tables 1 and 2 contain details of the measurement method and a list of the atoms including atomic coordinates and displacement parameters.
Crystal: | Colourless bipyramid |
Size: | 0.62 × 0.40 × 0.36 mm |
Wavelength: | Mo Kα radiation (0.71073 Å) |
μ: | 0.9 cm−1 |
Diffractometer, scan mode: | Xcalibur Sapphire3, ω-scans |
2θmax, completeness: | 61°, >99% |
N(hkl)measured, N(hkl)unique, Rint: | 26340, 4099, 0.033 |
Criterion for Iobs, N(hkl)gt: | Iobs > 2 σ(Iobs), 3126 |
N(param)refined: | 183 |
Programs: | CrysAlis [10], SHELX [11], ORTEP [12] |
Atom | x | y | z | Uiso*/Ueq |
---|---|---|---|---|
C1 | 0.01862(15) | 0.59334(12) | 0.27258(13) | 0.0379(3) |
C2 | 0.13551(15) | 0.65792(12) | 0.36266(12) | 0.0400(3) |
H2 | 0.1752 | 0.7141 | 0.3379 | 0.048* |
C3 | 0.19615(15) | 0.63988(12) | 0.49272(13) | 0.0394(3) |
C4 | 0.31447(15) | 0.71328(12) | 0.58847(12) | 0.0382(3) |
C5 | 0.36337(16) | 0.72292(13) | 0.71587(13) | 0.0444(3) |
H5 | 0.3301 | 0.6817 | 0.7582 | 0.053* |
C6 | 0.46982(16) | 0.80513(13) | 0.76494(13) | 0.0458(4) |
C7 | 0.5583(2) | 0.85593(19) | 0.89453(15) | 0.0688(5) |
H7A | 0.6611 | 0.8384 | 0.9328 | 0.103* |
H7B | 0.5256 | 0.8248 | 0.9451 | 0.103* |
H7C | 0.5451 | 0.9372 | 0.8888 | 0.103* |
C8 | 0.5767(2) | 0.92746(17) | 0.67085(18) | 0.0693(5) |
H8A | 0.6134 | 0.9038 | 0.6206 | 0.104* |
H8B | 0.6583 | 0.9399 | 0.7563 | 0.104* |
H8C | 0.5216 | 0.9970 | 0.6372 | 0.104* |
C9 | −0.05302(14) | 0.60795(12) | 0.13556(12) | 0.0370(3) |
C10 | −0.03874(16) | 0.70784(12) | 0.08385(13) | 0.0418(3) |
H10 | 0.0150 | 0.7688 | 0.1362 | 0.050* |
C11 | −0.10414(16) | 0.71668(13) | −0.04498(14) | 0.0452(3) |
H11 | −0.0955 | 0.7845 | −0.0785 | 0.054* |
C12 | −0.18248(15) | 0.62654(14) | −0.12545(13) | 0.0440(3) |
C13 | −0.2483(2) | 0.63514(17) | −0.26531(15) | 0.0617(5) |
H13A | −0.2318 | 0.5650 | −0.2949 | 0.093* |
H13B | −0.2023 | 0.6968 | −0.2812 | 0.093* |
H13C | −0.3526 | 0.6491 | −0.3089 | 0.093* |
C14 | −0.19649(17) | 0.52778(14) | −0.07330(14) | 0.0497(4) |
H14 | −0.2486 | 0.4664 | −0.1257 | 0.060* |
C15 | −0.13500(17) | 0.51835(13) | 0.05445(14) | 0.0462(3) |
H15 | −0.1482 | 0.4517 | 0.0869 | 0.055* |
N1 | 0.48166(13) | 0.83981(11) | 0.66866(11) | 0.0447(3) |
N2 | 0.38682(13) | 0.78578(10) | 0.55933(10) | 0.0413(3) |
O1 | −0.03848(13) | 0.51164(9) | 0.30417(10) | 0.0535(3) |
H1 | 0.0160 | 0.5110 | 0.3930 | 0.080* |
O2 | 0.14793(13) | 0.56258(10) | 0.53075(10) | 0.0522(3) |
Source of material
A suspension of metallic sodium (0.4 g; 17.39 mmol) in anhydrous toluene was mixed with ethyl-1,5-dimethyl-1-H-pyrazole-3-carboxylate (2.5 g; 14.86 mmol). Then 1-p-tolylethanone (1.99 g; 14.86 mmol) was added at 0 °C. The resulting mixture was stirred at room temperature for 7 days. The precipitate formed was filtered, washed and neutralized in water to pH = 5.5 using acetic acid. After extraction with CH2Cl2, the organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo. Adding some milliliter of hexane, the product precipitated. Crystals of the title compound were obtained by slow evaporation. Yield: 32%, M.p. 132 − 134 °C.
Experimental details
All hydrogen atoms were inserted at calculated positions using a riding model. The Uiso values of the hydrogen atoms of methyl groups were set to 1.5Ueq(C) and the Uiso values of all other hydrogen atoms were set to 1.2Ueq of their parent atoms.
Discussion
β-Ketoenol-functionalized heterocycles, as one of the classical chelating ligands, play a significant role in coordination chemistry for over a century [1, 2] , several of these ligands have been reviewed [3, 4] . Complex formation of such systems with transition metals have additional features, including unusual optical, magnetic, photoactive, catalytic and electrochemical properties. The intramolecular H-bond found in these systems, in which two oxygen atoms are interconnected through the hydrogen atom by a conjugated single and double bonds, has been discussed in numerous studies [5], [6], [7], [8]. Crystals of β-ketoenols consist of packings of the enol tautomers stabilized by a strong intramolecular H-bond; that is, the H—O⋯H tautomerization and their interconversion.
The crystal structure of the title compound shows the formation of an intramolecular (O1—H⋯O2) interaction balancing the intra-electrostatic forces. The two oxygen atoms O1, O2 are separated by a distance of 2.5104(6) Å. Furthermore, the N1—N2 distance (1.3454(6) Å) is in good agreement with the lengths of bonds reported for analogous compounds [9]. N1, N2, C4, C5, and C6 atoms are in the same plane with a r.m.s. deviation of 0.0038 Å. The torsion angle O2—C3—C4—N2 of 170.12(6)° indicates that the pyrazolyl moiety undergoes slight inclination with respect to the plane discussed before. The torsion angle O1—C1—C9—C10 of 160.84(7)° indicates that the plane of phenyl ring undergoes a greater inclination relative to plane of the central moiety.
Acknowledgements
The authors extend their appreciation to the PPR2-MESRSFC-CNRST-P10 project (Morocco) for supporting this work. Sincere appreciation was also extended to the Deanship of Scientific Research at King Saud University for supporting this Prolific Research group (PRG-1437-29).
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