Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter September 16, 2017

Role of the gut-brain axis in the eating behavior of children with autism spectrum disorders

  • Justyna Siwek , Aleksandra Kawala-Janik and Piotr Walecki EMAIL logo

Abstract

Introduction:

The occurrence of autism spectrum disorders (ASD) has significantly increased in the last few years. One of the common problems in this group are eating disorders and ailments from the gastrointestinal systems. According to some studies, these problems have a significant impact on the occurrence and severity of symptoms in the neurological system, so it is crucial to increase the attention paid on the role of diet in the treatment of this disease. One of the theories connects ASD with disorders of the digestive system and the intestinal bacterial flora. This theory is based on the gut-brain axis, which means the interaction between the gastrointestinal and nervous systems.

Objectives:

To demonstrate the differences in behavior habits, interest in nutrition, and frequency of consumption of food products between children suffering from ASD and healthy children.

Materials and methods:

The study was conducted among 44 children suffering from ASD and 33 healthy children as a control group. Data were collected using a questionnaire that was specially designed for this study. The questionnaire contained questions about eating habits and the frequency of consumption of selected food products.

Results:

Parents of healthy children showed more interest in their children’s way of feeding and nutritional recommendations compared to parents of children with ASD (4% and 11.3%, respectively). In addition, 24.3% more children with ASD consulted with a nutritionist compared to the control group. Complaints of the digestive system were 21.1% more likely by children with ASD. Children suffering from ASD were characterized by a higher intake of red meat and giblets and less frequent consumption of milk and milk products compared to the control group. There were no statistically significant differences between the study group and the control group in terms of frequency of consumption of products, which are the source of gluten, artificial food additives-preservatives, and artificial colors.

Conclusions:

There are differences in the habits and eating behaviors and the frequency of consumption of selected food products between a group of children with ASD and a group of healthy children.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

1. Das UN. Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids. Nutrition 2013;29:1175–85.10.1016/j.nut.2013.01.012Search in Google Scholar PubMed

2. Neggers YH. Increasing prevalence, changes in diagnostic criteria, and nutritional risk factors for autism spectrum disorders. ISRN Nutr 2014;2014:514026.10.1155/2014/514026Search in Google Scholar PubMed PubMed Central

3. Compart PJ. The pathophysiology of autism. Glob Adv Health Med 2013;2:32–7.10.7453/gahmj.2013.092Search in Google Scholar PubMed PubMed Central

4. Yates K, Le Couteur A. Diagnosing autism. Paediatr Child Health (Oxf) 2009;19:55–9.10.1016/j.paed.2008.10.010Search in Google Scholar

5. Johnson CR, Turner K, Stewart PA, Schmidt B, Shui A, Macklin E, et al. Relationships between feeding problems, behavioral characteristics and nutritional quality in children with ASD. J Autism Dev Disord 2014;44:2175–84.10.1007/s10803-014-2095-9Search in Google Scholar PubMed

6. Attlee A, Kassem H, Hashim M, Obaid RS. Physical status and feeding behavior of children with autism. Indian J Pediatr 2015;82:682–7.10.1007/s12098-015-1696-4Search in Google Scholar PubMed

7. Kral TV, Eriksen WT, Souders MC, Pinto-Martin JA. Eating behaviors, diet quality, and gastrointestinal symptoms in children with autism spectrum disorders: a brief review. J Pediatr Nurs 2013;28:548–56.10.1016/j.pedn.2013.01.008Search in Google Scholar PubMed

8. Marí-Bauset S, Llopis-González A, Zazpe-García I, Marí-Sanchis A, Morales-Suárez-Varela M. Nutritional status of children with autism spectrum disorders (ASDs): a case-control study. J Autism Dev Disord 2015;45:203–12.10.1007/s10803-014-2205-8Search in Google Scholar PubMed

9. van De Sande MM, van Buul VJ, Brouns FJ. Autism and nutrition: the role of the gut-brain axis. Nutr Res Rev 2014;27:199–214.10.1017/S0954422414000110Search in Google Scholar PubMed

10. Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol Q Publ Hell Soc Gastroenterol 2015;28:203–9.Search in Google Scholar

11. Petra AI, Panagiotidou S, Hatziagelaki E, Stewart JM, Conti P, Theoharides TC. Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation. Clin Ther 2015;37:984–95.10.1016/j.clinthera.2015.04.002Search in Google Scholar PubMed PubMed Central

12. Sadowska J, Cierebiej M. Ocena sposobu żywienia i stanu odżywienia dzieci z autyzmem. Badania wstępne. Ped Współ Gastroenterol Hepatol Żyw Dziecka 2011;13:155–60.Search in Google Scholar

13. Przybylska-Felus M, Furgala A, Zwolinska-Wcislo M, Mazur M, Widera A, Thor P, et al. Disturbances of autonomic nervous system activity and diminished response to stress in patients with celiac disease. J Physiol Pharmacol 2014;65:833–41.Search in Google Scholar PubMed

14. Buie T. The relationship of autism and gluten. Clin Ther 2013;35:578–83.10.1016/j.clinthera.2013.04.011Search in Google Scholar PubMed

15. Volkert VM, Vaz PCM. Recent studies on feeding problems in children with autism. J Appl Behav Anal 2010;43:155–9.10.1901/jaba.2010.43-155Search in Google Scholar PubMed PubMed Central

16. Bandini LG, Anderson SE, Curtin C, Cermak S, Evans EW, Scampini R, et al. Food selectivity in children with autism spectrum disorders and typically developing children. J Pediatr 2010;157:259–64.10.1016/j.jpeds.2010.02.013Search in Google Scholar PubMed PubMed Central

17. Williams PG, Dalrymple N, Neal J. Eating habits of children with autism. Pediatr Nurs 2000;26:259–64.Search in Google Scholar PubMed

18. Curtin C, Hubbard K, Anderson SE, Mick E, Must A, Bandini LG. Food selectivity, mealtime behavior problems, spousal stress, and family food choices in children with and without autism spectrum disorder. J Autism Dev Disord 2015;45:3308–15.10.1007/s10803-015-2490-xSearch in Google Scholar PubMed PubMed Central

19. Must A, Curtin C, Hubbard K, Sikich L, Bedford J, Bandini L. Obesity prevention for children with developmental disabilities. Curr Obes Rep 2014;3:156–70.10.1007/s13679-014-0098-7Search in Google Scholar PubMed PubMed Central

20. Cermak SA, Curtin C, Bandini LG. Food selectivity and sensory sensitivity in children with autism spectrum disorders. J Am Diet Assoc 2010;110:238–46.10.1016/j.jada.2009.10.032Search in Google Scholar PubMed PubMed Central

21. Grubišić V, Parpura V. The second brain in autism spectrum disorder: could connexin 43 expressed in enteric glial cells play a role? Front Cell Neurosci 2015;9:242.10.3389/fncel.2015.00242Search in Google Scholar PubMed PubMed Central

22. Marí-Bauset S, Zazpe I, Mari-Sanchis A, Llopis-González A, Morales-Suárez-Varela M. Food selectivity in autism spectrum disorders: a systematic review. J Child Neurol 2014;29:1554–61.10.1177/0883073813498821Search in Google Scholar PubMed

23. Herndon AC, DiGuiseppi C, Johnson SL, Leiferman J, Reynolds A. Does nutritional intake differ between children with autism spectrum disorders and children with typical development? J Autism Dev Disord 2009;39:212–22.10.1007/s10803-008-0606-2Search in Google Scholar PubMed

24. Zimmer MH, Hart LC, Manning-Courtney P, Murray DS, Bing NM, Summer S. Food variety as a predictor of nutritional status among children with autism. J Autism Dev Disord 2012;42:549–56.10.1007/s10803-011-1268-zSearch in Google Scholar PubMed PubMed Central

25. Graf-Myles J, Farmer C, Thurm A, Royster C, Kahn P, Soskey L, et al. Dietary adequacy of children with autism compared with controls and the impact of restricted diet. J Dev Behav Pediatr 2013;34:449–59.10.1097/DBP.0b013e3182a00d17Search in Google Scholar PubMed PubMed Central

26. Hyman SL, Stewart PA, Schmidt B, Cain C, Lemcke N, Foley JT, et al. Nutrient intake from food in children with autism. Pediatrics 2012;130(Suppl):S145–53.10.1542/peds.2012-0900LSearch in Google Scholar PubMed PubMed Central

27. Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, et al. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutr Metab (Lond) 2011;8:34.10.1186/1743-7075-8-34Search in Google Scholar PubMed PubMed Central

28. Brzozowski B, Mazur-Bialy A, Pajdo R, Kwiecien S, Bilski J, Zwolinska-Wcislo M, et al. Mechanisms by which stress affects the experimental and clinical inflammatory bowel disease (IBD): Role of brain-gut axis. Curr Neuropharmacol 2016;14:892–900.10.2174/1570159X14666160404124127Search in Google Scholar PubMed

29. Valicenti-McDermott M, Lawson K, Hottinger K, Seijo R, Schechtman M, Shulman L, et al. Parental stress in families of children with autism and other developmental disabilities. J Child Neurol 2015;30:1728–35.10.1177/0883073815579705Search in Google Scholar PubMed

30. Mankad D, Dupuis A, Smile S, Roberts W, Brian J, Lui T, et al. A randomized, placebo controlled trial of ω-3 fatty acids in the treatment of young children with autism. Mol Autism 2015;6:18.10.1186/s13229-015-0010-7Search in Google Scholar PubMed PubMed Central

31. Bent S, Bertoglio K, Hendren RL. ω-3 fatty acids for autistic spectrum disorder: a systematic review. J Autism Dev Disord 2009;39:1145–54.10.1007/s10803-009-0724-5Search in Google Scholar PubMed PubMed Central

32. Schnoll R, Burshteyn D. Nutrition in the treatment of attention-deficit hyperactivity disorder: a neglected but important aspect. Appl Psychophysiol Biofeedback 2003;28:63–75.10.1023/A:1022321017467Search in Google Scholar PubMed

33. Jarosz M, Stoś K, Walkiewicz A. Żelazo. In: M. Jarosz, editor. Normy żywienia populacji polskiej-nowelizacja. Warszawa, 2012:128–30.Search in Google Scholar

34. Hergüner S, Keleşoğlu FM, Çöpür M, Tanıdır C. Ferritin and iron levels in children with autistic disorder. Eur J Pediatr 2012;171:143–6.10.1007/s00431-011-1506-6Search in Google Scholar PubMed

35. Dosman CF, Brian JA, Drmic IE, Senthilselvan A, Harford MM, Smith RW, et al. Children with autism: effect of iron supplementation on sleep and ferritin. Pediatr Neurol 2007;36:152–8.10.1016/j.pediatrneurol.2006.11.004Search in Google Scholar PubMed

Received: 2017-8-18
Accepted: 2017-8-18
Published Online: 2017-9-16
Published in Print: 2017-9-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 2.5.2024 from https://www.degruyter.com/document/doi/10.1515/bams-2017-0020/html
Scroll to top button