Abstract
Breast cancer is the second most frequent tumor in Mexico. Patients diagnosed with this cancer have a higher risk of developing a second malignancy. The objective of our study was to see the frequency, types of second cancers, and its impact on survival, in order to be able to deliver a proper and efficient follow up to these patients, because our patients differ from the population of breast cancer in the rest of the world. Our patients are younger and therefore at higher risk.
The clinical records of breast cancer patients treated at the Instituto Nacional de Cancerologia Mexico from 1983 to 1992 were reviewed. In 1370 evaluable patients, 77 (5.6%) developed a second neoplasm, of those, 56 (72.7%) in the contralateral breast and 21 in other sites (27.3%), thyroid was the most frequent followed by ovary and endometrium. Mean age of the patients was 51.5 yr, 45.5 for the other breast and 55.5 for other malignancies (p=0.01). Median survival for all the group was of 180 mo (3–238).
Patients were significantly younger in the contralateral breast group, although all our breast cancer patients are younger. The most frequent second malignancy after the other breast, was thyroid followed by ovary and endometrium with similar survival for both groups.
Similar content being viewed by others
References
Lynch HT, Fustaro RM, Lynch J. Hereditary cancer in adults. Cancer Detect Prev 1995;19:219–233.
Henderson BE, Feigelson HS. Hormonal carcinogenesis. Carcinogenesis 2000;21:427–433.
Travis LB, Holowaty EJ, Bergfeldt K. Risk of leukemia after platinum-based chemotherapy for ovarian cancer. N Engl J Med 1999;340:351–357.
Shapiro LC, Recht A. Side effects of adjuvant treatment of breast cancer. N Engl J Med 2001;344:1997–2008.
Georgiannos SN, et al. Secondary neoplasms of the breast. Cancer 2001;92:2259–2266
Rodríguez Cuevas S, et al. Breast carcinoma presents a decade earlier in Mexican woman than in the United States or European Countries. Cancer 2001;91:863–868.
Zeichner Gancz I, Mohar Betancourt A, Ramírez Ugalde MT. Epidemiología de cancer de mama en el Instituto Nacional de Cancerologia, 1989–1990. Revista INCcan 1993;39:1825–1830.
Zeichner Gancz I. Epidemiologia del cancer de Mama. V Reunión de Investigación en Cáncer en México. U.N.A.M. México 2001;104–108.
Volk NV, Pompe-Kirn V. Second primary cancers in breast cancer patients in Slovenia. Cancer Causes Control 1997;8:764–770.
Lewi EF, Neto AS. Bilateral breast cancer at the John Hopkins Hospital. Cancer 1971;28:1279–1301.
Bernstein JL, Lapinski RH, Thakore SS, Doucette JT, Thompson WD. The descriptive epidemiology of second primary breast cancer. Epidemiology 2003;14:552–558.
Chen Y, Semenciw R, Kliewer E, Shi Y, Mao Y. Incidence of second primary breast cancer among women with a first primary in Manitoba, Canada. Breast Cancer Res Treat 2001;67:35–40.
Brenner H, Siegle S, Stegmaier C, Ziegler H. Second primary neoplasms following breast cancer in Saarland, Germany, 1968–1987. Eur J Cancer 1993;29A:1410–1414.
Evans HS, Lewis CM, Robinson D, Bell CM, Moller H, Hodgson SV. Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England. Br J Cancer 2001;84:435–440.
Schenker JG, Levinsky R, Ohel G. Multiple Primary malignant neoplasms in breast cancer in Israel. Cancer 1984;54:145–150.
Sadetzki S, Calderon-Margalit R, Peretz C, Novikov I, Barchana M, Papa MZ. Second primary breast and thyroid cancers (Israel). Cancer Causes Control 2003;14:367–375.
Knudson GA. Antioncogenes and human cancer. Proc Natl Acad Sci USA 1993;90:10914–10921.
Land CE, et al. Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950–1990. Radiat Res 2003;160:707–717.
Kinsinger LS, et al. Chemoprevention of breast cancer: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 2002;137:59–69.
Takashima S, Mitsuyama S, Ueo H, Ohashi Y. Second cancers after adjuvant tamoxifen therapy for breast cancer in Japan. Ann Oncol 2000;11:1537–1543.
Li CI, Rossing MA, Voigt LF, Daling JR. Multiple primary breast and thyroid cancers: role of age at diagnosis and cancer treatments (United States). Cancer Causes Control 2000;11:805–811.
Rubino C, de Vathaire F, Diallo I, Shamsaldin A, Le MG. Increased risk of second cancers following breast cancer: role of the initial treatment. Breast Cancer Res Treat 2000;61:183–195.
Matsuyama Y, et al. Second cancers after adjuvant tamoxifen therapy for breast cancer in Japan. Ann Oncol 2000;11:1537–1543.
Chabner E, et al. Family history and treatment outcome in young women after breast-conserving surgery and radiation therapy for early-stage breast cancer. J Clin Oncol 1998;16:2045–2051.
Fowble B, et al. Second cancers after conservative surgery and radiation for stages I–II breast cancer: identifying a subset of women at increased risk. Int J Radio Oncology Biol Phys 2001;51:679–690.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Vidal-Millan, S., Zeichner-Gancz, I., Flores-Estrada, D. et al. A descriptive study of second primary malignancies associated to breast cancer in a Mexican Hispanic population. Med Oncol 22, 17–22 (2005). https://doi.org/10.1385/MO:22:1:017
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/MO:22:1:017