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Appropriate timing of glimepiride administration in patients with type 2 diabetes millitus

A study in mediterranean countries

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Abstract

Sulfonylureas are used to treat patients with type 2 diabetes mellitus when diet and exercise fail. Glimepiride, a new sulfonylurea, can be administered in one daily dose, thanks to its pharmacokinetic properties. We attempted to establish the optimal time of day for the administration of Glimepiride in a group of patients from the Mediterranean area by clinical trial. No relationship was found between the time of administration and fasting blood glucose values, or HbA1c, or the frequency or severity of hypoglycemic episodes.

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Authors and Affiliations

  1. Endocrinology and Diabetes Unit., IDIBAPS, Hospital Clínic, School of Medicine, Barcelona University, Barcelona, Spain

    Ramon Gomis

  2. Second Dept. of Internal Medicine “Propedeuntic Athens University”, Evangelismos Hospital, Athens, Greece

    Sotirios A. Raptis

  3. Research and Development Department, Hoechst Marion Roussel, S. A. (Spain), Barcelona, Spain

    Ramon Ravella

Authors
  1. Ramon Gomis
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  2. Sotirios A. Raptis
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  3. Ramon Ravella
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Correspondence to Ramon Gomis.

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Gomis, R., Raptis, S.A. & Ravella, R. Appropriate timing of glimepiride administration in patients with type 2 diabetes millitus. Endocr 13, 117–121 (2000). https://doi.org/10.1385/ENDO:13:1:117

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  • DOI: https://doi.org/10.1385/ENDO:13:1:117

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