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Vitamin E attenuates myocardial ischemia-reperfusion injury in murine AIDS

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Abstract

The incidence of myocardial infarction in patients who have the aquired immunodeficiency syndrome (AIDS) is increasing. However, no effective therapeutic agents have been discovered to reduce myocardial ischemia-reperfusion (I/R) injury in pathologies associated with AIDS. The aim of this study was to determine if infarct size is increased in murine AIDS after I/R injury and if I/R injury could be attenuated with vitamin E supplementation. Three groups of mice were studied: control, murine AIDS, and murine AIDS with vitamin E supplementation. Anesthetized mice were subjected to 30 min of left anterior descending coronary artery occlusion and 120 min of reperfusion. The hearts in mice that had murine AIDS had a larger infarct size compared to controls after I/R injury. Vitamin E supplementation significantly reduced infarct size and inhibited polymorphonuclear neutrophil (PMN) CD11b expression (p<0.05). However, vitamin E supplementation did not affect PMN reactive oxygen species (ROS) production and platelet CD62p expression. These results suggest that the reduction of myocardial I/R injury with vitamin E supplementation may be the result of the inhibition of PMN CD11b expression. Vitamin E may be a promising prophylactic agent for the reduction of the severity of myocardial I/R injury in patients who have AIDS.

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Authors and Affiliations

  1. Divison of Health Prevention Science, College of Public Health, University of Arizona, 85724, Tucson, AZ

    Yinhong Chen & Ronald Ross Watson Ph.D.

  2. Cardiovascular and Thoracic Surgery and The Sarver Heart Center, School of Medicine, University of Arizona, 85724, Tucson, AZ

    Yinhong Chen, Grace Davis-Gorman & Paul F. McDonagh

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  1. Yinhong Chen
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  2. Grace Davis-Gorman
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Correspondence to Ronald Ross Watson Ph.D..

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Chen, Y., Davis-Gorman, G., Watson, R.R. et al. Vitamin E attenuates myocardial ischemia-reperfusion injury in murine AIDS. Cardiovasc Toxicol 2, 119–127 (2002). https://doi.org/10.1385/CT:2:2:119

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