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Regulation of Neural Stem Cell Death

  • Chapter
Neural Development and Stem Cells

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Nervous system development is a complex process that begins with a small number of cells and ends with a highly organized and specialized organ. Neural stem cells play a critical role in this process. These cells have the capacity to self-renew, proliferate, and give rise to lineage-restricted neuronal and/or glial progenitor cells and postmitotic specialized daughter cells. The number of neural stem cells contributing to neural development depends on the balance between proliferation, self-renewal, differentiation, and cell death. Studies of apoptosis-associated molecules have indicated significant cell death in neural precursor cells, defined as neural stem cells and lineage restricted progenitors, and immature neurons prior to the generation of synaptic contacts. These studies complement the extensive body of work dedicated to cell death regulation in mature neurons, where competition for limited amounts of target-derived neurotrophic factors plays a direct role in activating cell death pathways during neuronal histogenesis and cell injury. The striking neurodevelopmental abnormalities observed in mice with targeted disruptions in genes regulating cell death emphasizes the importance of programmed cell death during development. Studies of these animals further reveal that cell death regulation is remarkably specific to cell type and stage of neural differentiation.

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  1. Departments of Pathology and Neurobiology, Division of Neuropathology, University of Alabama at Birmingham, Birmingham, AL

    Rizwan S. Akhtar & Kevin A. Roth

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  1. Rizwan S. Akhtar
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  1. National Institute on Aging, Baltimore, MD

    Mahendra S. Rao MBBS, PhD

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Akhtar, R.S., Roth, K.A. (2006). Regulation of Neural Stem Cell Death. In: Rao, M.S. (eds) Neural Development and Stem Cells. Contemporary Neuroscience. Humana Press. https://doi.org/10.1385/1-59259-914-1:097

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