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Tara Z. Baris, Dominique N. Wagner, David I. Dayan, Xiao Du, Pierre U. Blier, Nicolas Pichaud, Marjorie F. Oleksiak, Douglas L. Crawford
Evolved genetic and phenotypic differences due to mitochondrial-nuclear interactions
www.plosgenetics.org
www.plosgenetics.org
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(migrants)Tj
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3.7984 0 Td
([)Tj
0.83 0.64 0.02 0 k
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(,)Tj
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1.7404 0 Td
(43)Tj
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0.83 0.64 0.02 0 k
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2.9764 0 Td
(and)Tj
1.7348 0 Td
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1.542 0 Td
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2.2621 0 Td
(speciation)Tj
4.2689 0 Td
([)Tj
0.83 0.64 0.02 0 k
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(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(29)Tj
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(,)Tj
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(46)Tj
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(the)Tj
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1.4683 0 Td
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(49)Tj
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(].)Tj
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3.1748 0 Td
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-34.8262 -1.3039 Td
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2.5738 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.4683 0 Td
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1.7121 0 Td
(specific)Tj
3.1918 0 Td
(mt-haplotypes,)Tj
6.1965 0 Td
(and)Tj
1.7348 0 Td
(if)Tj
0.771 0 Td
(so,)Tj
1.3153 0 Td
(do)Tj
1.2529 0 Td
(these)Tj
2.2564 0 Td
(differences)Tj
4.5637 0 Td
(affect)Tj
2.3754 0 Td
(OxPhos)Tj
-32.9383 -1.2982 Td
(function?)Tj
3.9911 0 Td
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1.338 0 Td
(answer)Tj
3.033 0 Td
(these)Tj
2.2507 0 Td
(questions,)Tj
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(155)Tj
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5.6466 0 Td
(NJ)Tj
/F12 1 Tf
1.2812 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F12 1 Tf
0.9581 0 Td
[()6()8( )11()2(\n)20()4()13()12(\r)14( )7()-4()]TJ
/F8 1 Tf
4.6601 0 Td
(individuals)Tj
4.6488 0 Td
(were)Tj
2.1147 0 Td
(gen-)Tj
-35.807 -1.2983 Td
(otyped)Tj
2.948 0 Td
(at)Tj
/F13 1 Tf
0 Tc
0.9524 0 Td
(>)Tj
/F8 1 Tf
-0.004 Tc
(11,000)Tj
3.5943 0 Td
(SNPs,)Tj
2.5795 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.109 0 Td
(cardiac)Tj
3.1011 0 Td
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3.3845 0 Td
(metabolisms)Tj
5.2611 0 Td
(were)Tj
2.126 0 Td
(measured.)Tj
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-32.1163 -1.3039 Td
(with)Tj
1.9955 0 Td
(southern)Tj
3.7871 0 Td
(and)Tj
1.7291 0 Td
(northern)Tj
3.8154 0 Td
(mt-haplotypes)Tj
5.9754 0 Td
(are)Tj
1.4513 0 Td
(present)Tj
3.1635 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(60/40)Tj
2.4548 0 Td
(ratio,)Tj
2.3187 0 Td
(respectively.)Tj
5.1137 0 Td
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1.61 0 Td
(dem-)Tj
-35.0189 -1.2983 Td
(onstrate)Tj
3.4582 0 Td
(significant)Tj
4.388 0 Td
(allele)Tj
2.245 0 Td
(frequency)Tj
4.1839 0 Td
(differences)Tj
4.5695 0 Td
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0.9524 0 Td
(349)Tj
1.6441 0 Td
(SNP)Tj
1.9899 0 Td
(loci)Tj
1.6667 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.4684 0 Td
(two)Tj
1.7121 0 Td
(mt-haplo-)Tj
-31.8045 -1.2982 Td
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2.5001 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(different)Tj
3.6566 0 Td
(nuclear)Tj
3.1975 0 Td
(genotype)Tj
3.8551 0 Td
(and)Tj
1.7291 0 Td
(mt-haplotype)Tj
5.6182 0 Td
(combinations)Tj
5.709 0 Td
(are)Tj
1.4456 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
-35.1663 -1.2983 Td
(significant)Tj
4.388 0 Td
(OxPhos)Tj
3.3845 0 Td
(metabolic)Tj
4.1442 0 Td
(differences.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 457.6818 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
3.7984 0 Td
(and)Tj
1.989 0 Td
(discussion)Tj
ET
Q
q
1 j
1 J
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10 0 0 10 200.0125 440.674 cm
BT
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1 TL
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2.0182 0 Td
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4.7168 0 Td
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1.1849 0 Td
(sequencing)Tj
4.7112 0 Td
(\(GBS\))Tj
2.6758 0 Td
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0.83 0.64 0.02 0 k
(50)Tj
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1.8482 0 Td
(datasets)Tj
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2.2847 0 Td
(1\))Tj
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2.2053 0 Td
(a)Tj
0.652 0 Td
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5.6523 0 Td
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1.0262 0 Td
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2.5228 0 Td
(nuclear-mitochondrial)Tj
9.2862 0 Td
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5.2157 0 Td
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-35.3137 -1.2983 Td
(2\))Tj
1.0318 0 Td
(3-population)Tj
5.4198 0 Td
(dataset)Tj
2.9933 0 Td
(\(Maine,)Tj
3.3562 0 Td
(MK,)Tj
2.0069 0 Td
(and)Tj
1.7348 0 Td
(Georgia)Tj
3.4016 0 Td
(individuals\))Tj
4.9889 0 Td
(to)Tj
1.0262 0 Td
(ascertain)Tj
3.7814 0 Td
(the)Tj
1.4683 0 Td
(effect)Tj
2.3641 0 Td
(of)Tj
1.0148 0 Td
(recent)Tj
-34.5881 -1.2982 Td
(admixture.)Tj
4.5807 0 Td
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2.2847 0 Td
(filtering,)Tj
3.617 0 Td
(11,705)Tj
2.8233 0 Td
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2.1203 0 Td
(distributed)Tj
4.5978 0 Td
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(10,180)Tj
/F12 1 Tf
2.8233 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F12 1 Tf
0.9638 0 Td
[()6()8( )11()2(\n)20()4()13()12(\r)14( )7()-4()]TJ
/F8 1 Tf
-32.3544 -1.304 Td
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7.1942 0 Td
([)Tj
0.83 0.64 0.02 0 k
(51)Tj
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1.389 0 Td
(the)Tj
1.4683 0 Td
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5.108 0 Td
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2.3527 0 Td
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2.211 0 Td
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Q
q
1 j
1 J
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(drial)Tj
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Q
q
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1 TL
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2.8856 0 Td
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3.719 0 Td
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(sur-)Tj
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2.0749 0 Td
([)Tj
0.83 0.64 0.02 0 k
(52)Tj
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(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(53)Tj
0 g
(].)Tj
1.7405 0 Td
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4.3936 0 Td
(it)Tj
0.7824 0 Td
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0.8504 0 Td
(unlikely)Tj
3.4299 0 Td
(that)Tj
1.7744 0 Td
(a)Tj
0.6577 0 Td
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(maintain)Tj
3.8381 0 Td
(biologically)Tj
4.7905 0 Td
(important)Tj
-33.1084 -1.3039 Td
(mito-nuclear)Tj
5.4368 0 Td
(interactions)Tj
4.9662 0 Td
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0.9525 0 Td
(many)Tj
2.4774 0 Td
(loci)Tj
1.6668 0 Td
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1.0318 0 Td
(a)Tj
0.6576 0 Td
(panmictic)Tj
4.218 0 Td
(population)Tj
4.5921 0 Td
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2.9877 0 Td
(migration)Tj
4.1952 0 Td
(=)Tj
0.805 0 Td
(0.5)Tj
1.3947 0 Td
(of)Tj
-35.3818 -1.2983 Td
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3.5092 0 Td
(population)Tj
4.5921 0 Td
(size,)Tj
1.9106 0 Td
(Ne\))Tj
1.7177 0 Td
([)Tj
0.83 0.64 0.02 0 k
(54)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(56)Tj
0 g
(].)Tj
3.5433 0 Td
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1.6101 0 Td
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3.1238 0 Td
(that)Tj
1.7744 0 Td
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(mito-nuclear)Tj
5.4368 0 Td
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-33.664 -1.2983 Td
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2.1996 0 Td
(may)Tj
1.9276 0 Td
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0.7711 0 Td
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2.2677 0 Td
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0.8447 0 Td
(extensive)Tj
3.8891 0 Td
(standing)Tj
3.668 0 Td
(genetic)Tj
3.0671 0 Td
(variation)Tj
3.804 0 Td
(and)Tj
1.7292 0 Td
(many)Tj
2.4774 0 Td
(genes)Tj
2.4435 0 Td
(of)Tj
1.0148 0 Td
(small)Tj
2.3244 0 Td
(effect)Tj
-34.9056 -1.3039 Td
(affect)Tj
2.3754 0 Td
(biological)Tj
4.0875 0 Td
(traits.)Tj
2.4775 0 Td
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1.3379 0 Td
(investigate)Tj
4.4617 0 Td
(whether)Tj
3.4753 0 Td
(these)Tj
2.2563 0 Td
(interactions)Tj
4.9663 0 Td
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3.5263 0 Td
(genomes)Tj
3.77 0 Td
(do)Tj
1.2529 0 Td
(affect)Tj
-33.9871 -1.2982 Td
(allele)Tj
2.228 0 Td
(frequencies,)Tj
5.0003 0 Td
(we)Tj
1.3209 0 Td
(calculated)Tj
4.1952 0 Td
(F)Tj
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q
1 j
1 J
0 w
7.4999 0 0 6.6659 332.7307 250.3559 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
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(ST)Tj
ET
Q
q
1 j
1 J
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BT
/F8 1 Tf
1 TL
-0.004 Tc
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(values)Tj
2.6588 0 Td
(for)Tj
1.3777 0 Td
(each)Tj
2.0182 0 Td
(of)Tj
1.0035 0 Td
(the)Tj
1.4626 0 Td
(11,705)Tj
2.812 0 Td
(SNPs)Tj
2.3414 0 Td
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1.457 0 Td
(MK-specific)Tj
5.1024 0 Td
(data-)Tj
-35.5518 -1.2982 Td
(set,)Tj
1.525 0 Td
(using)Tj
2.3924 0 Td
(the)Tj
1.4683 0 Td
(two)Tj
1.7122 0 Td
(mt-haplotypes)Tj
5.9754 0 Td
(as)Tj
1.0148 0 Td
(independent)Tj
5.2723 0 Td
(groups)Tj
2.9707 0 Td
(or)Tj
1.0941 0 Td
(populations.)Tj
5.1817 0 Td
(F)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 491.3574 237.3165 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(ST)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 501.6755 239.0173 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
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(provides)Tj
3.651 0 Td
(a)Tj
0.6519 0 Td
(statisti-)Tj
-34.469 -1.3039 Td
(cally)Tj
2.024 0 Td
(robust)Tj
2.7892 0 Td
(measure)Tj
3.583 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
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